| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Woodford Investment Management Ltd | 6,202,525 | 281,222,000 | 20.36% | ||
| 2 | FMR LLC | 4,702,797 | 213,225,000 | 15.43% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,099,103 | 140,513,000 | 10.17% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 2,513,569 | 113,966,000 | 8.25% | ||
| 5 | BlackRock Fund Advisors | 1,187,018 | 53,819,000 | 3.90% | ||
| 6 | WESTFIELD CAPITAL MANAGEMENT CO LP | 987,979 | 44,795,000 | 3.24% | ||
| 7 | STATE STREET CORP | 968,805 | 43,925,000 | 3.18% | ||
| 8 | Visium Asset Management, LP | 959,427 | 43,501,000 | 3.15% | ||
| 9 | CITADEL ADVISORS LLC | 824,450 | 37,381,000 | 2.71% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 767,650 | 34,805,000 | 2.52% | ||
| 11 | Palo Alto Investors LP | 695,918 | 31,553,000 | 2.28% | ||
| 12 | VANGUARD GROUP INC | 509,392 | 23,096,000 | 1.67% | ||
| 13 | NORTHERN TRUST CORP | 488,340 | 22,141,000 | 1.60% | ||
| 14 | JENNISON ASSOCIATES LLC | 404,765 | 18,352,000 | 1.33% | ||
| 15 | OAK RIDGE INVESTMENTS LLC | 378,185 | 17,147,000 | 1.24% | ||
| 16 | Invesco Ltd. | 363,690 | 16,490,000 | 1.19% | ||
| 17 | BB BIOTECH AG | 320,000 | 14,509,000 | 1.05% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 283,922 | 12,873,000 | 0.93% | ||
| 19 | NORGES BANK | 259,077 | 11,746,000 | 0.85% | ||
| 20 | Rock Springs Capital Management LP | 248,000 | 11,244,000 | 0.81% | ||
| 21 | DEUTSCHE BANK AG\ | 247,558 | 11,222,000 | 0.81% | ||
| 22 | GUGGENHEIM CAPITAL LLC | 209,591 | 9,503,000 | 0.69% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 205,060 | 9,297,000 | 0.67% | ||
| 24 | AXA S.A. | 181,876 | 8,246,000 | 0.60% | ||
| 25 | TEACHERS ADVISORS, LLC | 170,379 | 7,725,000 | 0.56% | ||
| 26 | TURNER INVESTMENTS LLC | 169,120 | 7,668,000 | 0.56% | ||
| 27 | Bank of New York Mellon Corp | 165,804 | 7,518,000 | 0.54% | ||
| 28 | COLUMBUS CIRCLE INVESTORS | 159,956 | 7,252,000 | 0.52% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 148,827 | 6,748,000 | 0.49% | ||
| 30 | PRUDENTIAL FINANCIAL INC | 119,270 | 5,408,000 | 0.39% | ||
| 31 | CREDIT SUISSE AG/ | 114,847 | 5,207,000 | 0.38% | ||
| 32 | BNP Paribas Asset Management Holding S.A. | 106,719 | 4,839,000 | 0.35% | ||
| 33 | BlackRock Investment Management, LLC | 104,321 | 4,730,000 | 0.34% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 97,700 | 4,430,000 | 0.32% | Call | |
| 35 | JPMORGAN CHASE & CO | 96,198 | 4,362,000 | 0.32% | ||
| 36 | PUTNAM INVESTMENTS LLC | 95,796 | 4,344,000 | 0.31% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 92,860 | 4,211,000 | 0.30% | ||
| 38 | Employees Retirement System of Texas | 90,000 | 4,081,000 | 0.30% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 89,200 | 4,044,000 | 0.29% | Put | |
| 40 | EVENTIDE ASSET MANAGEMENT, LLC | 87,172 | 3,952,000 | 0.29% | ||
| 41 | CLOUGH CAPITAL PARTNERS L P | 65,400 | 2,965,000 | 0.21% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,040 | 2,586,000 | 0.19% | ||
| 43 | Informed Momentum Co LLC | 56,093 | 2,543,000 | 0.18% | ||
| 44 | Allianz Asset Management GmbH | 55,404 | 2,512,000 | 0.18% | ||
| 45 | BNP PARIBAS FINANCIAL MARKETS | 51,339 | 2,327,710 | 0.17% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 45,440 | 2,060,000 | 0.15% | ||
| 47 | SPHERA FUNDS MANAGEMENT LTD. | 45,133 | 2,046,000 | 0.15% | ||
| 48 | Swiss National Bank | 43,000 | 1,950,000 | 0.14% | ||
| 49 | PEAK6 Group LLC | 42,700 | 1,936,000 | 0.14% | Call | |
| 50 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 41,800 | 1,895,000 | 0.14% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
