| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Woodford Investment Management Ltd | 6,379,661 | 434,519,000 | 21.04% | ||
| 2 | FMR LLC | 4,728,412 | 322,052,000 | 15.59% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,100,683 | 211,188,000 | 10.23% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 2,493,796 | 169,853,000 | 8.22% | ||
| 5 | BlackRock Fund Advisors | 1,135,587 | 77,345,000 | 3.75% | ||
| 6 | Visium Asset Management, LP | 978,900 | 66,673,000 | 3.23% | ||
| 7 | STATE STREET CORP | 809,434 | 55,130,000 | 2.67% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 771,313 | 52,534,000 | 2.54% | ||
| 9 | Palo Alto Investors LP | 695,518 | 47,372,000 | 2.29% | ||
| 10 | VANGUARD GROUP INC | 520,034 | 35,419,000 | 1.72% | ||
| 11 | DEUTSCHE BANK AG\ | 481,920 | 32,822,000 | 1.59% | ||
| 12 | CITADEL ADVISORS LLC | 469,605 | 31,985,000 | 1.55% | ||
| 13 | JENNISON ASSOCIATES LLC | 406,677 | 27,699,000 | 1.34% | ||
| 14 | OAK RIDGE INVESTMENTS LLC | 376,746 | 25,660,000 | 1.24% | ||
| 15 | Invesco Ltd. | 373,550 | 25,442,000 | 1.23% | ||
| 16 | NORTHERN TRUST CORP | 352,971 | 24,041,000 | 1.16% | ||
| 17 | NORGES BANK | 348,206 | 23,716,000 | 1.15% | ||
| 18 | BB BIOTECH AG | 320,000 | 21,795,000 | 1.06% | ||
| 19 | PINNACLE ASSOCIATES LTD | 296,484 | 20,194,000 | 0.98% | ||
| 20 | Rock Springs Capital Management LP | 248,000 | 16,891,000 | 0.82% | ||
| 21 | WELLS FARGO & COMPANY/MN | 245,639 | 16,730,000 | 0.81% | ||
| 22 | ALLIANCEBERNSTEIN L.P. | 367,720 | 16,672,000 | 0.81% | ||
| 23 | COLUMBUS CIRCLE INVESTORS | 218,943 | 14,912,000 | 0.72% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 212,911 | 14,501,000 | 0.70% | ||
| 25 | AXA S.A. | 199,398 | 13,581,000 | 0.66% | ||
| 26 | TEACHERS ADVISORS, LLC | 170,496 | 11,612,000 | 0.56% | ||
| 27 | Bank of New York Mellon Corp | 162,937 | 11,097,000 | 0.54% | ||
| 28 | VOYA INVESTMENT MANAGEMENT LLC | 162,373 | 11,059,000 | 0.54% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 154,270 | 10,507,000 | 0.51% | ||
| 30 | LORD, ABBETT & CO. LLC | 152,484 | 10,386,000 | 0.50% | ||
| 31 | TURNER INVESTMENTS LLC | 150,110 | 10,224,000 | 0.50% | ||
| 32 | CREDIT SUISSE AG/ | 120,866 | 8,233,000 | 0.40% | ||
| 33 | BNP Paribas Asset Management Holding S.A. | 120,667 | 8,219,000 | 0.40% | ||
| 34 | PRUDENTIAL FINANCIAL INC | 115,070 | 7,837,000 | 0.38% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 107,866 | 7,347,000 | 0.36% | ||
| 36 | BlackRock Investment Management, LLC | 104,947 | 7,148,000 | 0.35% | ||
| 37 | EVENTIDE ASSET MANAGEMENT, LLC | 104,800 | 7,138,000 | 0.35% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 98,900 | 6,736,000 | 0.33% | Put | |
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 95,200 | 6,484,000 | 0.31% | Call | |
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 91,700 | 6,246,000 | 0.30% | ||
| 41 | RENAISSANCE TECHNOLOGIES LLC | 90,600 | 6,171,000 | 0.30% | ||
| 42 | Employees Retirement System of Texas | 90,000 | 6,130,000 | 0.30% | ||
| 43 | Ghost Tree Capital, LLC | 90,000 | 6,130,000 | 0.30% | ||
| 44 | JPMORGAN CHASE & CO | 86,223 | 5,873,000 | 0.28% | ||
| 45 | PUTNAM INVESTMENTS LLC | 78,727 | 5,362,000 | 0.26% | ||
| 46 | ROYAL BANK OF CANADA | 71,807 | 4,890,000 | 0.24% | ||
| 47 | GUGGENHEIM CAPITAL LLC | 69,612 | 4,741,000 | 0.23% | ||
| 48 | Informed Momentum Co LLC | 63,746 | 4,342,000 | 0.21% | ||
| 49 | GOLDMAN SACHS GROUP INC | 58,112 | 3,958,000 | 0.19% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,940 | 3,946,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
