| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Woodford Investment Management Ltd | 10,301,751 | 617,384,000 | 28.13% | ||
| 2 | FMR LLC | 5,159,381 | 309,408,000 | 14.10% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,360,550 | 201,532,000 | 9.18% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 3,012,916 | 180,685,000 | 8.23% | ||
| 5 | BlackRock Fund Advisors | 1,337,144 | 80,189,000 | 3.65% | ||
| 6 | STATE STREET CORP | 1,071,717 | 64,272,000 | 2.93% | ||
| 7 | Palo Alto Investors LP | 934,455 | 56,039,000 | 2.55% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 875,767 | 52,520,000 | 2.39% | ||
| 9 | ALLIANCEBERNSTEIN L.P. | 780,643 | 46,815,000 | 2.13% | ||
| 10 | Redmile Group, LLC | 701,659 | 42,078,000 | 1.92% | ||
| 11 | VANGUARD GROUP INC | 591,879 | 35,495,000 | 1.62% | ||
| 12 | PINNACLE ASSOCIATES LTD | 429,922 | 25,782,000 | 1.17% | ||
| 13 | JENNISON ASSOCIATES LLC | 407,907 | 24,462,000 | 1.11% | ||
| 14 | NORTHERN TRUST CORP | 392,812 | 23,557,000 | 1.07% | ||
| 15 | WELLS FARGO & COMPANY/MN | 373,720 | 22,412,000 | 1.02% | ||
| 16 | NORGES BANK | 371,553 | 21,282,000 | 0.97% | ||
| 17 | BB BIOTECH AG | 350,000 | 20,990,000 | 0.96% | ||
| 18 | PointState Capital LP | 350,000 | 20,990,000 | 0.96% | ||
| 19 | OAK RIDGE INVESTMENTS LLC | 335,447 | 20,117,000 | 0.92% | ||
| 20 | Rock Springs Capital Management LP | 308,000 | 18,471,000 | 0.84% | ||
| 21 | WESTFIELD CAPITAL MANAGEMENT CO LP | 277,150 | 16,621,000 | 0.76% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 266,239 | 15,966,000 | 0.73% | ||
| 23 | Invesco Ltd. | 262,271 | 15,728,000 | 0.72% | ||
| 24 | VOYA INVESTMENT MANAGEMENT LLC | 260,193 | 15,604,000 | 0.71% | ||
| 25 | Nantahala Capital Management, LLC | 229,000 | 13,733,000 | 0.63% | Put | |
| 26 | OppenheimerFunds, Inc. | 167,780 | 10,062,000 | 0.46% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 160,136 | 9,603,000 | 0.44% | ||
| 28 | Bank of New York Mellon Corp | 159,944 | 9,591,000 | 0.44% | ||
| 29 | AXA S.A. | 153,571 | 9,210,000 | 0.42% | ||
| 30 | BLACKROCK ADVISORS LLC | 138,421 | 8,301,000 | 0.38% | ||
| 31 | BlackRock Investment Management, LLC | 136,518 | 8,187,000 | 0.37% | ||
| 32 | COLUMBUS CIRCLE INVESTORS | 131,128 | 7,864,000 | 0.36% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 130,146 | 7,805,000 | 0.36% | ||
| 34 | SECTORAL ASSET MANAGEMENT INC | 123,946 | 7,433,000 | 0.34% | ||
| 35 | Hood River Capital Management LLC | 121,600 | 7,292,000 | 0.33% | ||
| 36 | EVENTIDE ASSET MANAGEMENT, LLC | 120,000 | 7,196,000 | 0.33% | ||
| 37 | AMUNDI ASSET MANAGEMENT US, INC. | 119,324 | 7,156,000 | 0.33% | ||
| 38 | CREDIT SUISSE AG/ | 113,151 | 6,787,000 | 0.31% | ||
| 39 | Employees Retirement System of Texas | 106,000 | 6,357,000 | 0.29% | ||
| 40 | DEUTSCHE BANK AG\ | 101,231 | 6,068,000 | 0.28% | ||
| 41 | JPMORGAN CHASE & CO | 93,780 | 5,624,000 | 0.26% | ||
| 42 | TURNER INVESTMENTS LLC | 85,390 | 5,120,000 | 0.23% | ||
| 43 | GUGGENHEIM CAPITAL LLC | 79,796 | 4,785,000 | 0.22% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,200 | 4,690,000 | 0.21% | Put | |
| 45 | GOLDMAN SACHS GROUP INC | 73,828 | 4,427,000 | 0.20% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 73,531 | 4,410,000 | 0.20% | ||
| 47 | TEACHERS ADVISORS, LLC | 68,755 | 4,123,000 | 0.19% | ||
| 48 | ROYAL BANK OF CANADA | 64,458 | 3,865,000 | 0.18% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 64,100 | 3,844,000 | 0.18% | ||
| 50 | CITADEL ADVISORS LLC | 62,124 | 3,726,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
