| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,109,930 | 156,753,000 | 16.01% | ||
| 2 | Woodford Investment Management Ltd | 3,708,171 | 141,430,000 | 14.44% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,439,296 | 131,175,000 | 13.40% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 2,500,712 | 95,378,000 | 9.74% | ||
| 5 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,734,928 | 66,170,000 | 6.76% | ||
| 6 | STATE STREET CORP | 1,189,576 | 45,366,000 | 4.63% | ||
| 7 | BlackRock Fund Advisors | 1,071,514 | 40,868,000 | 4.17% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 738,429 | 28,164,000 | 2.88% | ||
| 9 | Palo Alto Investors LP | 695,918 | 26,542,000 | 2.71% | ||
| 10 | JENNISON ASSOCIATES LLC | 576,292 | 21,980,000 | 2.24% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 544,021 | 20,749,000 | 2.12% | ||
| 12 | NORTHERN TRUST CORP | 424,632 | 16,194,000 | 1.65% | ||
| 13 | VANGUARD GROUP INC | 393,645 | 15,014,000 | 1.53% | ||
| 14 | Visium Asset Management, LP | 302,039 | 11,520,000 | 1.18% | ||
| 15 | Invesco Ltd. | 264,751 | 10,097,000 | 1.03% | ||
| 16 | TURNER INVESTMENTS LLC | 249,990 | 9,535,000 | 0.97% | ||
| 17 | Rock Springs Capital Management LP | 237,500 | 9,058,000 | 0.93% | ||
| 18 | TEACHERS ADVISORS, LLC | 195,175 | 7,444,000 | 0.76% | ||
| 19 | GUGGENHEIM CAPITAL LLC | 191,066 | 7,287,000 | 0.74% | ||
| 20 | NORGES BANK | 189,264 | 7,219,000 | 0.74% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 164,913 | 6,289,000 | 0.64% | ||
| 22 | PRUDENTIAL FINANCIAL INC | 162,170 | 6,185,000 | 0.63% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 156,500 | 5,969,000 | 0.61% | Put | |
| 24 | Bank of New York Mellon Corp | 151,785 | 5,789,000 | 0.59% | ||
| 25 | CLOUGH CAPITAL PARTNERS L P | 145,200 | 5,538,000 | 0.57% | ||
| 26 | CREDIT SUISSE AG/ | 128,066 | 4,885,000 | 0.50% | ||
| 27 | PUTNAM INVESTMENTS LLC | 118,271 | 4,511,000 | 0.46% | ||
| 28 | CITADEL ADVISORS LLC | 104,337 | 3,980,000 | 0.41% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 102,300 | 3,902,000 | 0.40% | Call | |
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,908 | 3,810,000 | 0.39% | ||
| 31 | JPMORGAN CHASE & CO | 94,125 | 3,590,000 | 0.37% | ||
| 32 | Employees Retirement System of Texas | 90,000 | 3,433,000 | 0.35% | ||
| 33 | SPHERA FUNDS MANAGEMENT LTD. | 88,133 | 3,361,000 | 0.34% | ||
| 34 | BlackRock Investment Management, LLC | 85,996 | 3,280,000 | 0.33% | ||
| 35 | AMERICAN CENTURY COMPANIES INC | 85,113 | 3,246,000 | 0.33% | ||
| 36 | BLACKROCK ADVISORS LLC | 79,159 | 3,019,000 | 0.31% | ||
| 37 | DEUTSCHE BANK AG\ | 68,066 | 2,594,000 | 0.26% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,637 | 1,855,000 | 0.19% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 48,303 | 1,843,000 | 0.19% | ||
| 40 | SMITH ASSET MANAGEMENT GROUP LP | 47,480 | 1,811,000 | 0.18% | ||
| 41 | D. E. Shaw & Co., Inc. | 45,099 | 1,720,000 | 0.18% | ||
| 42 | GOLDMAN SACHS GROUP INC | 44,676 | 1,704,000 | 0.17% | ||
| 43 | MARINER INVESTMENT GROUP LLC | 43,600 | 1,663,000 | 0.17% | ||
| 44 | Connor, Clark & Lunn Investment Management Ltd. | 38,100 | 1,453,000 | 0.15% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 36,100 | 1,377,000 | 0.14% | ||
| 46 | Granahan Investment Management, LLC | 33,894 | 1,293,000 | 0.13% | ||
| 47 | Swiss National Bank | 33,500 | 1,278,000 | 0.13% | ||
| 48 | Informed Momentum Co LLC | 32,250 | 1,230,000 | 0.13% | ||
| 49 | RHUMBLINE ADVISERS | 31,596 | 1,205,000 | 0.12% | ||
| 50 | RUSSELL FRANK CO/ | 27,954 | 1,066,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
