| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Woodford Investment Management Ltd | 11,106,211 | 619,282,000 | 26.46% | ||
| 2 | FMR LLC | 5,659,308 | 315,733,000 | 13.49% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,482,764 | 250,093,000 | 10.69% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 3,158,012 | 176,185,000 | 7.53% | ||
| 5 | BlackRock Finance, Inc. | 2,733,934 | 152,526,000 | 6.52% | ||
| 6 | Capital World Investors | 1,323,114 | 73,817,000 | 3.15% | ||
| 7 | STATE STREET CORP | 1,068,172 | 59,594,000 | 2.55% | ||
| 8 | Palo Alto Investors LP | 1,055,855 | 58,906,000 | 2.52% | ||
| 9 | Redmile Group, LLC | 849,483 | 47,393,000 | 2.03% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 838,757 | 46,794,000 | 2.00% | ||
| 11 | VANGUARD GROUP INC | 699,858 | 39,045,000 | 1.67% | ||
| 12 | NORTHERN TRUST CORP | 422,491 | 23,572,000 | 1.01% | ||
| 13 | OAK RIDGE INVESTMENTS LLC | 419,974 | 23,430,000 | 1.00% | ||
| 14 | JENNISON ASSOCIATES LLC | 409,582 | 22,851,000 | 0.98% | ||
| 15 | PINNACLE ASSOCIATES LTD | 387,583 | 21,623,000 | 0.92% | ||
| 16 | NORGES BANK | 359,426 | 20,052,000 | 0.86% | ||
| 17 | BB BIOTECH AG | 350,000 | 19,527,000 | 0.83% | ||
| 18 | LOOMIS SAYLES & CO L P | 327,775 | 18,287,000 | 0.78% | ||
| 19 | GOLDMAN SACHS GROUP INC | 326,554 | 18,219,000 | 0.78% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 319,139 | 17,804,000 | 0.76% | ||
| 21 | WELLS FARGO & COMPANY/MN | 315,634 | 17,609,000 | 0.75% | ||
| 22 | Rock Springs Capital Management LP | 309,500 | 17,267,000 | 0.74% | ||
| 23 | CITADEL ADVISORS LLC | 284,497 | 15,872,000 | 0.68% | ||
| 24 | Invesco Ltd. | 260,690 | 14,544,000 | 0.62% | ||
| 25 | WESTFIELD CAPITAL MANAGEMENT CO LP | 239,194 | 13,345,000 | 0.57% | ||
| 26 | VOYA INVESTMENT MANAGEMENT LLC | 232,173 | 12,953,000 | 0.55% | ||
| 27 | Hood River Capital Management LLC | 188,936 | 10,541,000 | 0.45% | ||
| 28 | Bank of New York Mellon Corp | 171,970 | 9,594,000 | 0.41% | ||
| 29 | OppenheimerFunds, Inc. | 168,560 | 9,404,000 | 0.40% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 163,300 | 9,111,000 | 0.39% | Put | |
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 153,857 | 8,584,000 | 0.37% | ||
| 32 | AXA S.A. | 151,929 | 8,476,000 | 0.36% | ||
| 33 | CREDIT SUISSE AG/ | 147,733 | 8,241,000 | 0.35% | ||
| 34 | SECTORAL ASSET MANAGEMENT INC | 141,046 | 7,869,000 | 0.34% | ||
| 35 | EVENTIDE ASSET MANAGEMENT, LLC | 120,000 | 6,695,000 | 0.29% | ||
| 36 | AMUNDI ASSET MANAGEMENT US, INC. | 115,932 | 6,468,000 | 0.28% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 111,386 | 6,214,000 | 0.27% | ||
| 38 | Ghost Tree Capital, LLC | 100,000 | 5,579,000 | 0.24% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,900 | 5,127,000 | 0.22% | Call | |
| 40 | Employees Retirement System of Texas | 91,000 | 5,077,000 | 0.22% | ||
| 41 | HIGHLAND CAPITAL MANAGEMENT LP | 90,943 | 5,074,000 | 0.22% | ||
| 42 | JPMORGAN CHASE & CO | 90,153 | 5,029,000 | 0.21% | ||
| 43 | Opaleye Management Inc. | 87,100 | 4,859,000 | 0.21% | ||
| 44 | MORGAN STANLEY | 83,046 | 4,633,000 | 0.20% | ||
| 45 | DEUTSCHE BANK AG\ | 81,323 | 4,533,000 | 0.19% | ||
| 46 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 75,000 | 4,184,000 | 0.18% | ||
| 47 | TEACHERS ADVISORS, LLC | 70,522 | 3,934,000 | 0.17% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 68,431 | 3,818,000 | 0.16% | ||
| 49 | GUGGENHEIM CAPITAL LLC | 63,707 | 3,555,000 | 0.15% | ||
| 50 | Swiss National Bank | 62,300 | 3,476,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
