| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 20,481,442 | 462,676,000 | 19.38% | ||
| 2 | FMR LLC | 14,843,448 | 335,313,000 | 14.04% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,962,463 | 134,692,000 | 5.64% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 5,250,000 | 118,598,000 | 4.97% | Call | |
| 5 | VANGUARD GROUP INC | 4,829,652 | 109,102,000 | 4.57% | ||
| 6 | VIKING GLOBAL INVESTORS LP | 4,757,878 | 107,480,000 | 4.50% | ||
| 7 | GOLDMAN SACHS GROUP INC | 3,149,000 | 71,136,000 | 2.98% | Call | |
| 8 | JENNISON ASSOCIATES LLC | 3,053,525 | 68,979,000 | 2.89% | ||
| 9 | BlackRock Fund Advisors | 2,935,943 | 66,323,000 | 2.78% | ||
| 10 | WESTFIELD CAPITAL MANAGEMENT CO LP | 2,308,261 | 52,144,000 | 2.18% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,244,208 | 50,697,000 | 2.12% | ||
| 12 | FRANKLIN RESOURCES INC | 2,124,600 | 47,995,000 | 2.01% | ||
| 13 | STATE STREET CORP | 1,990,425 | 44,965,000 | 1.88% | ||
| 14 | GILDER GAGNON HOWE & CO LLC | 1,712,053 | 38,675,000 | 1.62% | ||
| 15 | PFM Health Sciences, LP | 1,632,175 | 36,871,000 | 1.54% | ||
| 16 | WADDELL & REED FINANCIAL INC | 1,533,496 | 34,642,000 | 1.45% | ||
| 17 | JANUS HENDERSON INVESTORS US LLC | 1,312,725 | 29,654,000 | 1.24% | ||
| 18 | ALKEON CAPITAL MANAGEMENT LLC | 1,291,770 | 29,182,000 | 1.22% | ||
| 19 | PALISADE CAPITAL MANAGEMENT, LP | 1,142,538 | 25,810,000 | 1.08% | ||
| 20 | LORD, ABBETT & CO. LLC | 1,099,421 | 24,836,000 | 1.04% | ||
| 21 | Point72 Asset Management, L.P. | 1,082,000 | 24,442,000 | 1.02% | ||
| 22 | JPMORGAN CHASE & CO | 949,809 | 21,457,000 | 0.90% | ||
| 23 | NORTHERN TRUST CORP | 935,493 | 21,132,000 | 0.89% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 897,500 | 20,274,000 | 0.85% | Call | |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 747,428 | 16,884,000 | 0.71% | ||
| 26 | NORGES BANK | 723,595 | 16,346,000 | 0.68% | ||
| 27 | PERCEPTIVE ADVISORS LLC | 653,000 | 14,751,000 | 0.62% | ||
| 28 | SABBY MANAGEMENT, LLC | 589,264 | 13,311,000 | 0.56% | ||
| 29 | HARVEY CAPITAL MANAGEMENT INC | 578,200 | 13,061,000 | 0.55% | ||
| 30 | BLACKROCK ADVISORS LLC | 556,436 | 12,570,000 | 0.53% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 538,700 | 12,170,000 | 0.51% | Put | |
| 32 | CREDIT SUISSE AG/ | 532,800 | 12,036,000 | 0.50% | Call | |
| 33 | FRED ALGER MANAGEMENT, LLC | 521,710 | 11,785,000 | 0.49% | ||
| 34 | Alberta Investment Management Corp | 516,896 | 11,677,000 | 0.49% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 472,252 | 10,668,000 | 0.45% | ||
| 36 | Invesco Ltd. | 457,530 | 10,336,000 | 0.43% | ||
| 37 | BAMCO INC /NY/ | 437,000 | 9,872,000 | 0.41% | ||
| 38 | Bank of New York Mellon Corp | 434,729 | 9,821,000 | 0.41% | ||
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 423,200 | 9,560,000 | 0.40% | ||
| 40 | Cupps Capital Management, LLC | 420,411 | 9,497,000 | 0.40% | ||
| 41 | GOLDMAN SACHS GROUP INC | 400,247 | 9,042,000 | 0.38% | ||
| 42 | Capital World Investors | 400,000 | 9,036,000 | 0.38% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 398,723 | 9,007,000 | 0.38% | ||
| 44 | AMERIPRISE FINANCIAL INC | 398,444 | 9,000,000 | 0.38% | ||
| 45 | CREDIT SUISSE AG/ | 369,350 | 8,343,000 | 0.35% | ||
| 46 | CITADEL ADVISORS LLC | 357,120 | 8,067,000 | 0.34% | ||
| 47 | TEACHERS ADVISORS, LLC | 354,598 | 8,010,000 | 0.34% | ||
| 48 | DEUTSCHE BANK AG\ | 318,841 | 7,200,000 | 0.30% | ||
| 49 | BlackRock Investment Management, LLC | 246,650 | 5,572,000 | 0.23% | ||
| 50 | Rhenman & Partners Asset Management AB | 230,000 | 5,196,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
