| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 20,481,442 | 650,286,000 | 20.58% | ||
| 2 | FMR LLC | 14,965,545 | 475,156,000 | 15.04% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,240,798 | 198,145,000 | 6.27% | ||
| 4 | VANGUARD GROUP INC | 4,882,201 | 155,011,000 | 4.91% | ||
| 5 | BlackRock Fund Advisors | 3,191,785 | 101,339,000 | 3.21% | ||
| 6 | VIKING GLOBAL INVESTORS LP | 2,956,266 | 93,861,000 | 2.97% | ||
| 7 | JENNISON ASSOCIATES LLC | 2,874,016 | 91,250,000 | 2.89% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 2,653,382 | 84,245,000 | 2.67% | ||
| 9 | WADDELL & REED FINANCIAL INC | 2,350,749 | 74,637,000 | 2.36% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,060,610 | 65,424,000 | 2.07% | ||
| 11 | Bank of New York Mellon Corp | 1,911,140 | 60,678,000 | 1.92% | ||
| 12 | STATE STREET CORP | 1,789,626 | 56,824,000 | 1.80% | ||
| 13 | GILDER GAGNON HOWE & CO LLC | 1,674,562 | 53,167,000 | 1.68% | ||
| 14 | JPMORGAN CHASE & CO | 1,494,897 | 47,463,000 | 1.50% | ||
| 15 | GOLDMAN SACHS GROUP INC | 1,411,600 | 44,818,000 | 1.42% | Call | |
| 16 | FRANKLIN RESOURCES INC | 1,333,500 | 42,339,000 | 1.34% | ||
| 17 | ALKEON CAPITAL MANAGEMENT LLC | 1,291,770 | 41,014,000 | 1.30% | ||
| 18 | LORD, ABBETT & CO. LLC | 1,289,609 | 40,945,000 | 1.30% | ||
| 19 | Capital World Investors | 1,343,000 | 40,867,000 | 1.29% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 1,093,281 | 34,712,000 | 1.10% | ||
| 21 | Point72 Asset Management, L.P. | 1,018,600 | 32,341,000 | 1.02% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,015,801 | 32,252,000 | 1.02% | ||
| 23 | PALISADE CAPITAL MANAGEMENT, LP | 1,002,114 | 31,817,000 | 1.01% | ||
| 24 | RA CAPITAL MANAGEMENT, L.P. | 1,000,000 | 31,750,000 | 1.00% | Call | |
| 25 | CITADEL ADVISORS LLC | 896,555 | 28,465,000 | 0.90% | ||
| 26 | NORTHERN TRUST CORP | 881,585 | 27,990,000 | 0.89% | ||
| 27 | SABBY MANAGEMENT, LLC | 864,437 | 27,446,000 | 0.87% | ||
| 28 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 679,631 | 21,578,000 | 0.68% | ||
| 29 | NORGES BANK | 669,391 | 21,253,000 | 0.67% | ||
| 30 | HARVEY CAPITAL MANAGEMENT INC | 577,700 | 18,341,000 | 0.58% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 551,200 | 17,501,000 | 0.55% | Put | |
| 32 | MORGAN STANLEY | 512,335 | 16,266,000 | 0.51% | ||
| 33 | BAMCO INC /NY/ | 497,530 | 15,797,000 | 0.50% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 489,316 | 15,535,000 | 0.49% | ||
| 35 | Invesco Ltd. | 457,530 | 14,527,000 | 0.46% | ||
| 36 | FRED ALGER MANAGEMENT, LLC | 450,045 | 14,289,000 | 0.45% | ||
| 37 | COLUMBUS CIRCLE INVESTORS | 431,345 | 13,695,000 | 0.43% | ||
| 38 | EVENTIDE ASSET MANAGEMENT, LLC | 423,200 | 13,437,000 | 0.43% | ||
| 39 | DEUTSCHE BANK AG\ | 359,803 | 11,422,000 | 0.36% | ||
| 40 | TEACHERS ADVISORS, LLC | 354,278 | 11,248,000 | 0.36% | ||
| 41 | AMERIPRISE FINANCIAL INC | 319,521 | 10,144,000 | 0.32% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 306,300 | 9,725,000 | 0.31% | Call | |
| 43 | Allen Investment Management, LLC | 300,000 | 9,525,000 | 0.30% | ||
| 44 | Bodri Capital Management, LLC | 300,000 | 9,525,000 | 0.30% | ||
| 45 | PFM Health Sciences, LP | 293,565 | 9,321,000 | 0.29% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 281,626 | 8,942,000 | 0.28% | ||
| 47 | Cupps Capital Management, LLC | 272,350 | 8,647,000 | 0.27% | ||
| 48 | GUGGENHEIM CAPITAL LLC | 222,812 | 7,074,000 | 0.22% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 221,394 | 7,030,000 | 0.22% | ||
| 50 | Asset Management One Co., Ltd. | 219,197 | 7,005,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
