| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 20,481,442 | 730,163,000 | 20.93% | ||
| 2 | FMR LLC | 15,136,743 | 539,625,000 | 15.47% | ||
| 3 | VANGUARD GROUP INC | 5,601,656 | 199,699,000 | 5.73% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,594,715 | 199,452,000 | 5.72% | ||
| 5 | OppenheimerFunds, Inc. | 3,928,435 | 140,049,000 | 4.02% | ||
| 6 | BlackRock Fund Advisors | 3,199,559 | 114,064,000 | 3.27% | ||
| 7 | Capital World Investors | 2,744,000 | 97,824,000 | 2.80% | ||
| 8 | STATE STREET CORP | 2,367,221 | 84,391,000 | 2.42% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,978,601 | 70,537,000 | 2.02% | ||
| 10 | FRANKLIN RESOURCES INC | 1,827,933 | 65,166,000 | 1.87% | ||
| 11 | WADDELL & REED FINANCIAL INC | 1,771,253 | 63,145,000 | 1.81% | ||
| 12 | JANUS HENDERSON INVESTORS US LLC | 1,626,247 | 57,976,000 | 1.66% | ||
| 13 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,479,504 | 52,744,000 | 1.51% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 1,540,932 | 50,959,000 | 1.46% | ||
| 15 | Invesco Ltd. | 1,266,595 | 45,154,000 | 1.29% | ||
| 16 | CITADEL ADVISORS LLC | 1,128,935 | 40,246,000 | 1.15% | ||
| 17 | JPMORGAN CHASE & CO | 1,009,336 | 35,982,000 | 1.03% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 965,500 | 34,420,000 | 0.99% | Put | |
| 19 | NORTHERN TRUST CORP | 916,704 | 32,681,000 | 0.94% | ||
| 20 | DEUTSCHE BANK AG\ | 891,970 | 31,796,000 | 0.91% | ||
| 21 | Visium Asset Management, LP | 867,117 | 30,913,000 | 0.89% | ||
| 22 | Bank of New York Mellon Corp | 814,679 | 29,043,000 | 0.83% | ||
| 23 | NORGES BANK | 789,447 | 28,144,000 | 0.81% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 766,260 | 27,317,000 | 0.78% | ||
| 25 | VOYA INVESTMENT MANAGEMENT LLC | 724,464 | 25,827,000 | 0.74% | ||
| 26 | EAGLE ASSET MANAGEMENT INC | 661,516 | 23,583,000 | 0.68% | ||
| 27 | BAMCO INC /NY/ | 638,000 | 22,745,000 | 0.65% | ||
| 28 | Tekla Capital Management LLC | 637,500 | 22,727,000 | 0.65% | ||
| 29 | LORD, ABBETT & CO. LLC | 595,723 | 21,238,000 | 0.61% | ||
| 30 | JENNISON ASSOCIATES LLC | 593,206 | 21,148,000 | 0.61% | ||
| 31 | HealthCor Management, L.P. | 586,564 | 20,911,000 | 0.60% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 553,900 | 19,747,000 | 0.57% | Call | |
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 548,848 | 19,566,000 | 0.56% | ||
| 34 | PALISADE CAPITAL MANAGEMENT, LP | 495,830 | 17,676,000 | 0.51% | ||
| 35 | FEDERATED HERMES, INC. | 491,760 | 17,531,000 | 0.50% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 458,785 | 16,356,000 | 0.47% | ||
| 37 | PointState Capital LP | 450,000 | 16,043,000 | 0.46% | ||
| 38 | HARVEY CAPITAL MANAGEMENT INC | 433,325 | 15,448,000 | 0.44% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 409,147 | 14,586,000 | 0.42% | ||
| 40 | FRED ALGER MANAGEMENT, LLC | 387,754 | 13,824,000 | 0.40% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 360,909 | 12,866,000 | 0.37% | ||
| 42 | TEACHERS ADVISORS, LLC | 351,864 | 12,544,000 | 0.36% | ||
| 43 | FRONTIER CAPITAL MANAGEMENT CO LLC | 345,384 | 12,313,000 | 0.35% | ||
| 44 | EVENTIDE ASSET MANAGEMENT, LLC | 334,700 | 11,932,000 | 0.34% | ||
| 45 | BLACKROCK ADVISORS LLC | 323,776 | 11,543,000 | 0.33% | ||
| 46 | AXA S.A. | 321,290 | 11,454,000 | 0.33% | ||
| 47 | MORGAN STANLEY | 321,183 | 11,449,000 | 0.33% | ||
| 48 | Point72 Asset Management, L.P. | 303,800 | 10,830,000 | 0.31% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 290,504 | 10,357,000 | 0.30% | ||
| 50 | BlackRock Investment Management, LLC | 281,840 | 10,048,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
