| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 24,213,838 | 677,019,000 | 20.81% | ||
| 2 | FMR LLC | 16,890,468 | 472,257,000 | 14.52% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 7,990,317 | 223,409,000 | 6.87% | ||
| 4 | VANGUARD GROUP INC | 6,319,539 | 176,694,000 | 5.43% | ||
| 5 | OppenheimerFunds, Inc. | 4,631,691 | 129,502,000 | 3.98% | ||
| 6 | BlackRock Fund Advisors | 3,549,078 | 99,232,000 | 3.05% | ||
| 7 | STATE STREET CORP | 3,364,426 | 94,072,000 | 2.89% | ||
| 8 | Capital World Investors | 3,334,000 | 93,219,000 | 2.87% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 2,698,066 | 75,439,000 | 2.32% | ||
| 10 | FRANKLIN RESOURCES INC | 2,588,417 | 72,372,000 | 2.22% | ||
| 11 | Point72 Asset Management, L.P. | 2,222,700 | 62,147,000 | 1.91% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 2,092,959 | 58,519,000 | 1.80% | ||
| 13 | WADDELL & REED FINANCIAL INC | 2,049,547 | 57,306,000 | 1.76% | ||
| 14 | FRED ALGER MANAGEMENT, LLC | 1,620,014 | 45,295,000 | 1.39% | ||
| 15 | ORBIMED ADVISORS LLC | 1,401,600 | 39,189,000 | 1.20% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,338,700 | 37,430,000 | 1.15% | Put | |
| 17 | Invesco Ltd. | 1,150,443 | 32,166,000 | 0.99% | ||
| 18 | DEUTSCHE BANK AG\ | 1,115,618 | 31,190,000 | 0.96% | ||
| 19 | JPMORGAN CHASE & CO | 1,034,322 | 28,920,000 | 0.89% | ||
| 20 | EAGLE ASSET MANAGEMENT INC | 1,031,373 | 28,837,000 | 0.89% | ||
| 21 | NORTHERN TRUST CORP | 985,205 | 27,547,000 | 0.85% | ||
| 22 | VOYA INVESTMENT MANAGEMENT LLC | 858,114 | 23,992,000 | 0.74% | ||
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 805,484 | 22,522,000 | 0.69% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 776,100 | 21,700,000 | 0.67% | Call | |
| 25 | NORGES BANK | 773,840 | 21,637,000 | 0.67% | ||
| 26 | Tekla Capital Management LLC | 715,299 | 20,000,000 | 0.61% | ||
| 27 | ROYAL BANK OF CANADA | 692,414 | 19,359,000 | 0.60% | ||
| 28 | SECTORAL ASSET MANAGEMENT INC | 690,700 | 19,312,000 | 0.59% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 675,017 | 18,873,000 | 0.58% | ||
| 30 | WEATHERBIE CAPITAL, LLC | 629,934 | 17,613,000 | 0.54% | ||
| 31 | CANADA PENSION PLAN INVESTMENT BOARD | 515,000 | 14,399,000 | 0.44% | ||
| 32 | FEDERATED HERMES, INC. | 491,760 | 13,750,000 | 0.42% | ||
| 33 | Palo Alto Investors LP | 485,100 | 13,563,000 | 0.42% | ||
| 34 | BARCLAYS PLC | 498,900 | 13,470,000 | 0.41% | Call | |
| 35 | Point72 Asset Management, L.P. | 450,000 | 12,582,000 | 0.39% | Call | |
| 36 | AMERIPRISE FINANCIAL INC | 442,318 | 12,368,000 | 0.38% | ||
| 37 | Bank of New York Mellon Corp | 427,225 | 11,945,000 | 0.37% | ||
| 38 | BARCLAYS PLC | 434,200 | 11,723,000 | 0.36% | Put | |
| 39 | HARVEY CAPITAL MANAGEMENT INC | 417,525 | 11,673,000 | 0.36% | ||
| 40 | GOLDMAN SACHS GROUP INC | 398,000 | 11,128,000 | 0.34% | Call | |
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 364,302 | 10,186,000 | 0.31% | ||
| 42 | TEACHERS ADVISORS, LLC | 362,844 | 10,145,000 | 0.31% | ||
| 43 | Ghost Tree Capital, LLC | 350,000 | 9,786,000 | 0.30% | Put | |
| 44 | MILLENNIUM MANAGEMENT LLC | 335,955 | 9,393,000 | 0.29% | ||
| 45 | EVENTIDE ASSET MANAGEMENT, LLC | 334,700 | 9,358,000 | 0.29% | ||
| 46 | AXA S.A. | 316,182 | 8,840,000 | 0.27% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 314,997 | 8,807,000 | 0.27% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 311,403 | 8,707,000 | 0.27% | ||
| 49 | GOLDMAN SACHS GROUP INC | 304,268 | 8,508,000 | 0.26% | ||
| 50 | BlackRock Investment Management, LLC | 293,964 | 8,219,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
