| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 20,481,442 | 677,321,000 | 20.78% | ||
| 2 | FMR LLC | 15,107,227 | 499,596,000 | 15.32% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,591,664 | 184,916,000 | 5.67% | ||
| 4 | VANGUARD GROUP INC | 5,453,010 | 180,331,000 | 5.53% | ||
| 5 | OppenheimerFunds, Inc. | 3,716,472 | 122,904,000 | 3.77% | ||
| 6 | BlackRock Fund Advisors | 3,390,611 | 112,128,000 | 3.44% | ||
| 7 | Capital World Investors | 3,121,000 | 103,211,000 | 3.17% | ||
| 8 | WADDELL & REED FINANCIAL INC | 2,104,904 | 69,609,000 | 2.14% | ||
| 9 | Point72 Asset Management, L.P. | 2,012,000 | 66,537,000 | 2.04% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,892,100 | 62,572,000 | 1.92% | ||
| 11 | FRANKLIN RESOURCES INC | 1,738,753 | 57,501,000 | 1.76% | ||
| 12 | JANUS HENDERSON INVESTORS US LLC | 1,619,537 | 53,558,000 | 1.64% | ||
| 13 | ALPS ADVISORS INC | 157,645 | 52,133,000 | 1.60% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 1,411,978 | 46,694,000 | 1.43% | ||
| 15 | Invesco Ltd. | 1,244,525 | 41,157,000 | 1.26% | ||
| 16 | CITADEL ADVISORS LLC | 1,240,119 | 41,010,000 | 1.26% | ||
| 17 | JENNISON ASSOCIATES LLC | 1,097,364 | 36,290,000 | 1.11% | ||
| 18 | DEUTSCHE BANK AG\ | 1,087,215 | 35,952,000 | 1.10% | ||
| 19 | Bank of New York Mellon Corp | 1,058,567 | 35,006,000 | 1.07% | ||
| 20 | JPMORGAN CHASE & CO | 1,016,149 | 33,605,000 | 1.03% | ||
| 21 | NORTHERN TRUST CORP | 899,105 | 29,734,000 | 0.91% | ||
| 22 | FRED ALGER MANAGEMENT, LLC | 877,529 | 29,020,000 | 0.89% | ||
| 23 | Visium Asset Management, LP | 861,420 | 28,487,000 | 0.87% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 859,000 | 28,407,000 | 0.87% | Put | |
| 25 | FEDERATED HERMES, INC. | 805,760 | 26,646,000 | 0.82% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 795,025 | 26,291,000 | 0.81% | ||
| 27 | NORGES BANK | 789,447 | 26,107,000 | 0.80% | ||
| 28 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 763,375 | 25,244,000 | 0.77% | ||
| 29 | VOYA INVESTMENT MANAGEMENT LLC | 727,339 | 24,053,000 | 0.74% | ||
| 30 | LORD, ABBETT & CO. LLC | 694,229 | 22,958,000 | 0.70% | ||
| 31 | HealthCor Management, L.P. | 678,700 | 22,445,000 | 0.69% | ||
| 32 | PALISADE CAPITAL MANAGEMENT, LP | 640,552 | 21,183,000 | 0.65% | ||
| 33 | BAMCO INC /NY/ | 638,000 | 21,099,000 | 0.65% | ||
| 34 | EAGLE ASSET MANAGEMENT INC | 616,354 | 20,382,000 | 0.63% | ||
| 35 | Avoro Capital Advisors LLC | 581,900 | 19,243,000 | 0.59% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 567,079 | 18,753,000 | 0.58% | ||
| 37 | Tekla Capital Management LLC | 562,500 | 18,602,000 | 0.57% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 533,790 | 17,652,000 | 0.54% | ||
| 39 | CANADA PENSION PLAN INVESTMENT BOARD | 515,000 | 17,031,000 | 0.52% | ||
| 40 | HARVEY CAPITAL MANAGEMENT INC | 440,775 | 14,576,000 | 0.45% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 365,469 | 12,086,000 | 0.37% | ||
| 42 | TEACHERS ADVISORS, LLC | 350,011 | 11,575,000 | 0.36% | ||
| 43 | AXA S.A. | 328,043 | 10,848,000 | 0.33% | ||
| 44 | EVENTIDE ASSET MANAGEMENT, LLC | 326,700 | 10,804,000 | 0.33% | ||
| 45 | BLACKROCK ADVISORS LLC | 318,536 | 10,534,000 | 0.32% | ||
| 46 | GILDER GAGNON HOWE & CO LLC | 307,831 | 10,180,000 | 0.31% | ||
| 47 | MORGAN STANLEY | 293,923 | 9,719,000 | 0.30% | ||
| 48 | BlackRock Investment Management, LLC | 280,325 | 9,270,000 | 0.28% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 275,677 | 9,117,000 | 0.28% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 265,300 | 8,773,000 | 0.27% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
