| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 20,481,442 | 857,763,000 | 21.20% | ||
| 2 | FMR LLC | 15,044,613 | 630,068,000 | 15.57% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,632,514 | 235,890,000 | 5.83% | ||
| 4 | VANGUARD GROUP INC | 5,302,962 | 222,089,000 | 5.49% | ||
| 5 | OppenheimerFunds, Inc. | 3,779,798 | 158,298,000 | 3.91% | ||
| 6 | Capital World Investors | 3,421,756 | 143,303,000 | 3.54% | ||
| 7 | BlackRock Fund Advisors | 3,207,084 | 134,313,000 | 3.32% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 3,020,512 | 126,499,000 | 3.13% | ||
| 9 | JENNISON ASSOCIATES LLC | 2,521,324 | 105,593,000 | 2.61% | ||
| 10 | FRANKLIN RESOURCES INC | 2,480,553 | 103,886,000 | 2.57% | ||
| 11 | WADDELL & REED FINANCIAL INC | 2,252,556 | 94,337,000 | 2.33% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,961,442 | 82,145,000 | 2.03% | ||
| 13 | Point72 Asset Management, L.P. | 1,347,256 | 56,423,000 | 1.39% | ||
| 14 | Invesco Ltd. | 1,332,936 | 55,823,000 | 1.38% | ||
| 15 | JPMORGAN CHASE & CO | 1,155,244 | 48,381,000 | 1.20% | ||
| 16 | DEUTSCHE BANK AG\ | 1,096,724 | 45,928,000 | 1.13% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 1,050,029 | 43,975,000 | 1.09% | ||
| 18 | Bank of New York Mellon Corp | 1,011,208 | 42,348,000 | 1.05% | ||
| 19 | LORD, ABBETT & CO. LLC | 968,098 | 40,544,000 | 1.00% | ||
| 20 | NORTHERN TRUST CORP | 847,437 | 35,491,000 | 0.88% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 845,177 | 35,396,000 | 0.87% | ||
| 22 | Visium Asset Management, LP | 836,322 | 35,025,000 | 0.87% | ||
| 23 | HealthCor Management, L.P. | 825,000 | 34,551,000 | 0.85% | ||
| 24 | VOYA INVESTMENT MANAGEMENT LLC | 752,889 | 31,531,000 | 0.78% | ||
| 25 | NORGES BANK | 703,443 | 29,460,000 | 0.73% | ||
| 26 | PALISADE CAPITAL MANAGEMENT, LP | 656,741 | 27,504,000 | 0.68% | ||
| 27 | BAMCO INC /NY/ | 639,100 | 26,766,000 | 0.66% | ||
| 28 | FEDERATED HERMES, INC. | 604,000 | 25,296,000 | 0.63% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 567,600 | 23,771,000 | 0.59% | Put | |
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 544,877 | 22,819,000 | 0.56% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 519,313 | 21,748,000 | 0.54% | ||
| 32 | Avoro Capital Advisors LLC | 495,000 | 20,731,000 | 0.51% | ||
| 33 | HARVEY CAPITAL MANAGEMENT INC | 444,425 | 18,528,000 | 0.46% | ||
| 34 | Tekla Capital Management LLC | 370,000 | 15,496,000 | 0.38% | ||
| 35 | TEACHERS ADVISORS, LLC | 364,838 | 15,279,000 | 0.38% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 362,701 | 15,190,000 | 0.38% | ||
| 37 | GILDER GAGNON HOWE & CO LLC | 311,184 | 13,032,000 | 0.32% | ||
| 38 | BLUE JAY CAPITAL MANAGEMENT, LLC | 300,000 | 12,564,000 | 0.31% | ||
| 39 | BLACKROCK ADVISORS LLC | 298,436 | 12,498,000 | 0.31% | ||
| 40 | PICTET ASSET MANAGEMENT LTD | 251,736 | 12,287,000 | 0.30% | ||
| 41 | BlackRock Investment Management, LLC | 283,682 | 11,881,000 | 0.29% | ||
| 42 | GUGGENHEIM CAPITAL LLC | 272,175 | 11,399,000 | 0.28% | ||
| 43 | EVENTIDE ASSET MANAGEMENT, LLC | 271,100 | 11,354,000 | 0.28% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 265,262 | 11,110,000 | 0.27% | ||
| 45 | MORGAN STANLEY | 264,057 | 11,058,000 | 0.27% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 225,200 | 9,431,000 | 0.23% | Call | |
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 193,100 | 8,087,000 | 0.20% | ||
| 48 | Rhenman & Partners Asset Management AB | 191,000 | 7,999,000 | 0.20% | ||
| 49 | GOLDMAN SACHS GROUP INC | 189,700 | 7,945,000 | 0.20% | Call | |
| 50 | Asset Management One Co., Ltd. | 192,036 | 7,654,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
