| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 25,819,768 | 821,327,000 | 21.46% | ||
| 2 | FMR LLC | 18,098,352 | 575,708,000 | 15.04% | ||
| 3 | VANGUARD GROUP INC | 6,868,996 | 218,502,000 | 5.71% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,719,121 | 213,735,000 | 5.58% | ||
| 5 | OppenheimerFunds, Inc. | 5,150,223 | 163,829,000 | 4.28% | ||
| 6 | FRANKLIN RESOURCES INC | 4,175,786 | 132,832,000 | 3.47% | ||
| 7 | Capital World Investors | 3,764,000 | 119,733,000 | 3.13% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 3,197,082 | 101,699,000 | 2.66% | ||
| 9 | STATE STREET CORP | 3,107,828 | 98,857,000 | 2.58% | ||
| 10 | BlackRock Fund Advisors | 2,554,287 | 81,252,000 | 2.12% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,310,681 | 73,503,000 | 1.92% | ||
| 12 | FRED ALGER MANAGEMENT, LLC | 2,177,381 | 69,262,000 | 1.81% | ||
| 13 | Point72 Asset Management, L.P. | 2,071,500 | 65,894,000 | 1.72% | ||
| 14 | WADDELL & REED FINANCIAL INC | 1,946,416 | 61,915,000 | 1.62% | ||
| 15 | JPMORGAN CHASE & CO | 1,554,619 | 49,453,000 | 1.29% | ||
| 16 | Palo Alto Investors LP | 1,481,930 | 47,140,000 | 1.23% | ||
| 17 | DEUTSCHE BANK AG\ | 1,214,067 | 38,617,000 | 1.01% | ||
| 18 | GOLDMAN SACHS GROUP INC | 1,179,191 | 37,510,000 | 0.98% | ||
| 19 | LORD, ABBETT & CO. LLC | 1,165,284 | 37,068,000 | 0.97% | ||
| 20 | Invesco Ltd. | 1,163,870 | 37,023,000 | 0.97% | ||
| 21 | EAGLE ASSET MANAGEMENT INC | 979,303 | 31,151,000 | 0.81% | ||
| 22 | PICTET ASSET MANAGEMENT LTD | 930,011 | 29,584,000 | 0.77% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 867,500 | 27,595,000 | 0.72% | Put | |
| 24 | FIRST TRUST ADVISORS LP | 822,536 | 26,165,000 | 0.68% | ||
| 25 | Senator Investment Group LP | 800,000 | 25,448,000 | 0.66% | ||
| 26 | VAN ECK ASSOCIATES CORP | 796,521 | 25,337,000 | 0.66% | ||
| 27 | NORGES BANK | 833,906 | 25,336,000 | 0.66% | ||
| 28 | Avoro Capital Advisors LLC | 792,499 | 25,209,000 | 0.66% | ||
| 29 | EverPoint Asset Management, LLC | 750,000 | 23,858,000 | 0.62% | ||
| 30 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 716,936 | 22,805,000 | 0.60% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 671,683 | 21,366,000 | 0.56% | ||
| 32 | FRONTIER CAPITAL MANAGEMENT CO LLC | 633,690 | 20,158,000 | 0.53% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 554,600 | 17,642,000 | 0.46% | Call | |
| 34 | CANADA PENSION PLAN INVESTMENT BOARD | 462,200 | 14,703,000 | 0.38% | ||
| 35 | NORTHERN TRUST CORP | 436,148 | 13,873,000 | 0.36% | ||
| 36 | ROYAL BANK OF CANADA | 417,668 | 13,286,000 | 0.35% | ||
| 37 | TimesSquare Capital Management, LLC | 383,200 | 12,190,000 | 0.32% | ||
| 38 | FEDERATED HERMES, INC. | 374,860 | 11,924,000 | 0.31% | ||
| 39 | Bank of New York Mellon Corp | 363,200 | 11,552,000 | 0.30% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 356,452 | 11,339,000 | 0.30% | ||
| 41 | EVENTIDE ASSET MANAGEMENT, LLC | 334,700 | 10,647,000 | 0.28% | ||
| 42 | HARVEY CAPITAL MANAGEMENT INC | 332,825 | 10,587,000 | 0.28% | ||
| 43 | AMERIPRISE FINANCIAL INC | 309,581 | 9,846,000 | 0.26% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 307,759 | 9,790,000 | 0.26% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 298,657 | 9,500,000 | 0.25% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 297,059 | 9,449,000 | 0.25% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 270,581 | 8,607,000 | 0.22% | ||
| 48 | HWG Holdings LP | 233,772 | 7,436,000 | 0.19% | ||
| 49 | DIMENSIONAL FUND ADVISORS LP | 225,404 | 7,171,000 | 0.19% | ||
| 50 | ACUTA CAPITAL PARTNERS, LLC | 220,000 | 6,998,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
