| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 20,481,442 | 507,121,000 | 19.75% | ||
| 2 | FMR LLC | 14,915,523 | 369,308,000 | 14.38% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,533,343 | 161,766,000 | 6.30% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 5,250,000 | 129,990,000 | 5.06% | Call | |
| 5 | VANGUARD GROUP INC | 4,830,617 | 119,606,000 | 4.66% | ||
| 6 | VIKING GLOBAL INVESTORS LP | 4,324,890 | 107,084,000 | 4.17% | ||
| 7 | GOLDMAN SACHS GROUP INC | 3,149,000 | 77,969,000 | 3.04% | Call | |
| 8 | BlackRock Fund Advisors | 2,926,912 | 72,470,000 | 2.82% | ||
| 9 | JENNISON ASSOCIATES LLC | 2,903,489 | 71,890,000 | 2.80% | ||
| 10 | JANUS HENDERSON INVESTORS US LLC | 2,613,343 | 64,706,000 | 2.52% | ||
| 11 | Bank of New York Mellon Corp | 2,201,449 | 54,509,000 | 2.12% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 2,118,188 | 52,446,000 | 2.04% | ||
| 13 | WADDELL & REED FINANCIAL INC | 2,026,124 | 50,166,000 | 1.95% | ||
| 14 | STATE STREET CORP | 1,887,017 | 46,716,000 | 1.82% | ||
| 15 | LORD, ABBETT & CO. LLC | 1,778,218 | 44,029,000 | 1.71% | ||
| 16 | GILDER GAGNON HOWE & CO LLC | 1,688,889 | 41,817,000 | 1.63% | ||
| 17 | FRANKLIN RESOURCES INC | 1,482,400 | 36,704,000 | 1.43% | ||
| 18 | ALKEON CAPITAL MANAGEMENT LLC | 1,291,770 | 31,984,000 | 1.25% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 1,097,914 | 27,184,000 | 1.06% | ||
| 20 | PALISADE CAPITAL MANAGEMENT, LP | 973,046 | 24,093,000 | 0.94% | ||
| 21 | JPMORGAN CHASE & CO | 957,478 | 23,707,000 | 0.92% | ||
| 22 | Point72 Asset Management, L.P. | 925,000 | 22,903,000 | 0.89% | ||
| 23 | NORTHERN TRUST CORP | 906,150 | 22,437,000 | 0.87% | ||
| 24 | Capital World Investors | 812,797 | 20,125,000 | 0.78% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 773,300 | 19,147,000 | 0.75% | Call | |
| 26 | NORGES BANK | 723,595 | 17,916,000 | 0.70% | ||
| 27 | CITADEL ADVISORS LLC | 647,694 | 16,037,000 | 0.62% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 625,236 | 15,481,000 | 0.60% | ||
| 29 | HARVEY CAPITAL MANAGEMENT INC | 576,200 | 14,266,000 | 0.56% | ||
| 30 | PFM Health Sciences, LP | 560,786 | 13,885,000 | 0.54% | ||
| 31 | BAMCO INC /NY/ | 502,100 | 12,432,000 | 0.48% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 490,400 | 12,142,000 | 0.47% | Put | |
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 478,058 | 11,836,000 | 0.46% | ||
| 34 | FRED ALGER MANAGEMENT, LLC | 463,284 | 11,471,000 | 0.45% | ||
| 35 | Invesco Ltd. | 457,530 | 11,328,000 | 0.44% | ||
| 36 | EVENTIDE ASSET MANAGEMENT, LLC | 423,200 | 10,478,000 | 0.41% | ||
| 37 | AMERIPRISE FINANCIAL INC | 380,781 | 9,428,000 | 0.37% | ||
| 38 | DEUTSCHE BANK AG\ | 356,851 | 8,833,000 | 0.34% | ||
| 39 | TEACHERS ADVISORS, LLC | 354,598 | 8,780,000 | 0.34% | ||
| 40 | Cupps Capital Management, LLC | 320,821 | 7,943,000 | 0.31% | ||
| 41 | CREDIT SUISSE AG/ | 316,629 | 7,839,000 | 0.31% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 314,870 | 7,796,000 | 0.30% | ||
| 43 | Bodri Capital Management, LLC | 300,000 | 7,428,000 | 0.29% | ||
| 44 | GOLDMAN SACHS GROUP INC | 231,225 | 5,725,000 | 0.22% | ||
| 45 | Lombard Odier Asset Management (USA) Corp | 225,000 | 5,571,000 | 0.22% | ||
| 46 | Rhenman & Partners Asset Management AB | 219,000 | 5,422,000 | 0.21% | ||
| 47 | BlackRock Investment Management, LLC | 218,506 | 5,410,000 | 0.21% | ||
| 48 | HWG Holdings LP | 213,428 | 5,284,000 | 0.21% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 213,225 | 5,280,000 | 0.21% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 192,180 | 4,758,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
