| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 20,481,442 | 667,490,000 | 20.86% | ||
| 2 | FMR LLC | 15,025,757 | 489,689,000 | 15.30% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,057,423 | 197,411,000 | 6.17% | ||
| 4 | VANGUARD GROUP INC | 5,131,359 | 167,231,000 | 5.23% | ||
| 5 | OppenheimerFunds, Inc. | 3,709,507 | 120,893,000 | 3.78% | ||
| 6 | Capital World Investors | 3,451,400 | 112,481,000 | 3.51% | ||
| 7 | BlackRock Fund Advisors | 3,276,380 | 106,777,000 | 3.34% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 2,814,149 | 91,713,000 | 2.87% | ||
| 9 | WADDELL & REED FINANCIAL INC | 2,636,471 | 85,922,000 | 2.68% | ||
| 10 | JENNISON ASSOCIATES LLC | 2,481,221 | 80,863,000 | 2.53% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,424,378 | 79,010,000 | 2.47% | ||
| 12 | Point72 Asset Management, L.P. | 2,247,300 | 73,240,000 | 2.29% | ||
| 13 | FRANKLIN RESOURCES INC | 2,087,000 | 68,016,000 | 2.13% | ||
| 14 | STATE STREET CORP | 1,929,610 | 62,887,000 | 1.97% | ||
| 15 | JPMORGAN CHASE & CO | 1,359,688 | 44,311,000 | 1.38% | ||
| 16 | Bank of New York Mellon Corp | 1,167,064 | 38,035,000 | 1.19% | ||
| 17 | DEUTSCHE BANK AG\ | 1,013,871 | 33,039,000 | 1.03% | ||
| 18 | NORTHERN TRUST CORP | 895,810 | 29,194,000 | 0.91% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 748,400 | 24,390,000 | 0.76% | Put | |
| 20 | HealthCor Management, L.P. | 725,000 | 23,628,000 | 0.74% | ||
| 21 | PALISADE CAPITAL MANAGEMENT, LP | 705,301 | 22,986,000 | 0.72% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 681,131 | 22,198,000 | 0.69% | ||
| 23 | NORGES BANK | 642,203 | 20,929,000 | 0.65% | ||
| 24 | FEDERATED HERMES, INC. | 633,400 | 20,643,000 | 0.65% | ||
| 25 | BAMCO INC /NY/ | 607,100 | 19,785,000 | 0.62% | ||
| 26 | PERCEPTIVE ADVISORS LLC | 600,240 | 19,562,000 | 0.61% | ||
| 27 | COLUMBUS CIRCLE INVESTORS | 528,576 | 17,226,000 | 0.54% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 511,522 | 16,671,000 | 0.52% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 503,886 | 16,420,000 | 0.51% | ||
| 30 | HARVEY CAPITAL MANAGEMENT INC | 503,300 | 16,402,000 | 0.51% | ||
| 31 | Invesco Ltd. | 471,381 | 15,363,000 | 0.48% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 426,755 | 13,908,000 | 0.43% | ||
| 33 | Allen Investment Management, LLC | 414,459 | 13,507,000 | 0.42% | ||
| 34 | Tourbillon Capital Partners, L.P. | 400,000 | 13,036,000 | 0.41% | ||
| 35 | Neuberger Berman Group LLC | 391,600 | 12,762,000 | 0.40% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 389,300 | 12,687,000 | 0.40% | Call | |
| 37 | LORD, ABBETT & CO. LLC | 383,759 | 12,507,000 | 0.39% | ||
| 38 | TEACHERS ADVISORS, LLC | 355,803 | 11,596,000 | 0.36% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 347,100 | 11,312,000 | 0.35% | Call | |
| 40 | GILDER GAGNON HOWE & CO LLC | 317,235 | 10,339,000 | 0.32% | ||
| 41 | MORGAN STANLEY | 290,293 | 9,462,000 | 0.30% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 286,375 | 9,333,000 | 0.29% | ||
| 43 | EVENTIDE ASSET MANAGEMENT, LLC | 271,100 | 8,835,000 | 0.28% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 260,914 | 8,503,000 | 0.27% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 257,148 | 8,381,000 | 0.26% | ||
| 46 | PointState Capital LP | 250,000 | 8,148,000 | 0.25% | ||
| 47 | BELLEVUE ASSET MANAGEMENT AG | 231,000 | 7,528,000 | 0.24% | ||
| 48 | Asset Management One Co., Ltd. | 217,705 | 7,260,000 | 0.23% | ||
| 49 | BlackRock Investment Management, LLC | 219,708 | 7,160,000 | 0.22% | ||
| 50 | CITADEL ADVISORS LLC | 211,952 | 6,908,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
