| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 7,288,300 | 69,676,000 | 26.11% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 4,148,114 | 39,656,000 | 14.86% | ||
| 3 | BlackRock Finance, Inc. | 3,724,714 | 35,608,000 | 13.34% | ||
| 4 | Camber Capital Management LP | 2,398,123 | 22,926,000 | 8.59% | ||
| 5 | VANGUARD GROUP INC | 1,323,137 | 12,649,000 | 4.74% | ||
| 6 | Rock Springs Capital Management LP | 1,200,000 | 11,472,000 | 4.30% | ||
| 7 | ARK INVESTMENT MANAGEMENT LLC | 982,170 | 9,390,000 | 3.52% | ||
| 8 | Redmile Group, LLC | 812,240 | 7,765,000 | 2.91% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 649,500 | 6,209,000 | 2.33% | ||
| 10 | STATE STREET CORP | 577,978 | 5,528,000 | 2.07% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 572,967 | 5,478,000 | 2.05% | ||
| 12 | ORBIMED ADVISORS LLC | 456,666 | 4,366,000 | 1.64% | ||
| 13 | NORTHERN TRUST CORP | 433,113 | 4,140,000 | 1.55% | ||
| 14 | HighTower Advisors, LLC | 265,095 | 2,535,000 | 0.95% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 258,192 | 2,468,000 | 0.92% | ||
| 16 | MORGAN STANLEY | 182,953 | 1,749,000 | 0.66% | ||
| 17 | Bank of New York Mellon Corp | 163,888 | 1,567,000 | 0.59% | ||
| 18 | ROYCE & ASSOCIATES LP | 156,412 | 1,495,000 | 0.56% | ||
| 19 | DEUTSCHE BANK AG\ | 139,833 | 1,335,000 | 0.50% | ||
| 20 | ROYAL BANK OF CANADA | 126,631 | 1,210,000 | 0.45% | ||
| 21 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 126,183 | 1,207,000 | 0.45% | ||
| 22 | GAMCO INVESTORS, INC. ET AL | 122,000 | 1,166,000 | 0.44% | ||
| 23 | PDT Partners, LLC | 104,430 | 998,000 | 0.37% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 104,390 | 998,000 | 0.37% | ||
| 25 | ACUTA CAPITAL PARTNERS, LLC | 100,292 | 959,000 | 0.36% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 82,200 | 786,000 | 0.29% | ||
| 27 | Allianz Asset Management GmbH | 80,182 | 767,000 | 0.29% | ||
| 28 | TFS CAPITAL LLC | 77,082 | 737,000 | 0.28% | ||
| 29 | A.R.T. Advisors, LLC | 71,227 | 680,000 | 0.25% | ||
| 30 | Teton Advisors, Inc. | 70,041 | 670,000 | 0.25% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 69,009 | 660,000 | 0.25% | ||
| 32 | TEACHERS ADVISORS, LLC | 68,699 | 657,000 | 0.25% | ||
| 33 | GROUP ONE TRADING LLC | 68,292 | 653,000 | 0.24% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 62,954 | 602,000 | 0.23% | ||
| 35 | D. E. Shaw & Co., Inc. | 58,177 | 556,000 | 0.21% | ||
| 36 | GOLDMAN SACHS GROUP INC | 54,906 | 525,000 | 0.20% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,600 | 512,000 | 0.19% | Put | |
| 38 | WELLS FARGO & COMPANY/MN | 49,424 | 472,000 | 0.18% | ||
| 39 | Swiss National Bank | 45,800 | 438,000 | 0.16% | ||
| 40 | RHUMBLINE ADVISERS | 42,661 | 408,000 | 0.15% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 41,700 | 399,000 | 0.15% | ||
| 42 | LPL Financial LLC | 39,445 | 377,000 | 0.14% | ||
| 43 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,129 | 307,000 | 0.12% | ||
| 44 | Spark Investment Management LLC | 30,000 | 286,000 | 0.11% | ||
| 45 | STATE OF WISCONSIN INVESTMENT BOARD | 29,000 | 277,000 | 0.10% | ||
| 46 | WOLVERINE TRADING LP /BD | 27,000 | 263,000 | 0.10% | Call | |
| 47 | AMERICAN INTERNATIONAL GROUP, INC. | 24,149 | 231,000 | 0.09% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 23,700 | 227,000 | 0.09% | ||
| 49 | METROPOLITAN LIFE INSURANCE CO/NY | 23,109 | 221,000 | 0.08% | ||
| 50 | Nationwide Fund Advisors | 22,020 | 211,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
