| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 1,461,268 | 25,864,000 | 15.71% | ||
| 2 | Visium Asset Management, LP | 1,370,000 | 24,249,000 | 14.73% | ||
| 3 | FMR LLC | 1,265,394 | 22,397,000 | 13.61% | ||
| 4 | RS INVESTMENT MANAGEMENT CO LLC | 981,002 | 17,364,000 | 10.55% | ||
| 5 | VHCP Management, LLC | 811,152 | 14,357,000 | 8.72% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 714,763 | 12,651,000 | 7.69% | ||
| 7 | ACUTA CAPITAL PARTNERS, LLC | 469,893 | 8,317,000 | 5.05% | ||
| 8 | BAKER BROS. ADVISORS LP | 435,540 | 7,709,000 | 4.68% | ||
| 9 | ALPS ADVISORS INC | 37,310 | 6,604,000 | 4.01% | ||
| 10 | Rock Springs Capital Management LP | 270,000 | 4,779,000 | 2.90% | ||
| 11 | Sio Capital Management, LLC | 269,785 | 4,775,000 | 2.90% | ||
| 12 | ORBIMED ADVISORS LLC | 222,223 | 3,933,000 | 2.39% | ||
| 13 | LAZARD ASSET MANAGEMENT LLC | 210,325 | 3,722,000 | 2.26% | ||
| 14 | Ghost Tree Capital, LLC | 97,135 | 1,719,000 | 1.04% | ||
| 15 | AWM Investment Company, Inc. | 78,540 | 1,390,000 | 0.84% | ||
| 16 | Alyeska Investment Group, L.P. | 67,079 | 1,187,000 | 0.72% | ||
| 17 | Cormorant Asset Management, LP | 61,500 | 1,089,000 | 0.66% | ||
| 18 | DAFNA Capital Management LLC | 53,241 | 942,000 | 0.57% | ||
| 19 | PICTET ASSET MANAGEMENT LTD | 31,100 | 551,000 | 0.33% | ||
| 20 | SECTORAL ASSET MANAGEMENT INC | 31,100 | 550,000 | 0.33% | ||
| 21 | BANK OF AMERICA CORP /DE/ | 19,055 | 337,000 | 0.20% | ||
| 22 | CITADEL ADVISORS LLC | 3,687 | 65,000 | 0.04% | ||
| 23 | PANAGORA ASSET MANAGEMENT INC | 1,503 | 27,000 | 0.02% | ||
| 24 | MORGAN STANLEY | 519 | 9,000 | 0.01% | ||
| 25 | Tower Research Capital LLC (TRC) | 175 | 3,000 | 0.00% | ||
| 26 | ROYAL BANK OF CANADA | 42 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
