| 1 |
ORBIMED ADVISORS LLC |
1,448,991 |
25,140,000 |
17.24% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
1,023,652 |
17,760,000 |
12.18% |
|
|
| 3 |
FMR LLC |
981,300 |
17,026,000 |
11.68% |
|
|
| 4 |
VHCP Management, LLC |
811,152 |
12,911,000 |
8.85% |
|
|
| 5 |
SECTORAL ASSET MANAGEMENT INC |
731,660 |
12,694,000 |
8.71% |
|
|
| 6 |
RS INVESTMENT MANAGEMENT CO LLC |
656,170 |
11,385,000 |
7.81% |
|
|
| 7 |
PICTET ASSET MANAGEMENT LTD |
348,668 |
5,938,000 |
4.07% |
|
|
| 8 |
GREAT POINT PARTNERS LLC |
339,863 |
5,896,000 |
4.04% |
|
|
| 9 |
Visium Asset Management, LP |
275,000 |
4,771,000 |
3.27% |
|
|
| 10 |
ACUTA CAPITAL PARTNERS, LLC |
228,612 |
3,966,000 |
2.72% |
|
|
| 11 |
LAZARD ASSET MANAGEMENT LLC |
204,825 |
3,553,000 |
2.44% |
|
|
| 12 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
200,000 |
3,470,000 |
2.38% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
194,023 |
3,366,000 |
2.31% |
|
|
| 14 |
BLACKROCK ADVISORS LLC |
131,300 |
2,278,000 |
1.56% |
|
|
| 15 |
SCOPIA CAPITAL MANAGEMENT LP |
125,000 |
2,169,000 |
1.49% |
|
|
| 16 |
BAKER BROS. ADVISORS LP |
100,000 |
1,735,000 |
1.19% |
|
|
| 17 |
Alyeska Investment Group, L.P. |
99,955 |
1,734,000 |
1.19% |
|
|
| 18 |
DAFNA Capital Management LLC |
93,541 |
1,623,000 |
1.11% |
|
|
| 19 |
HIGHLAND CAPITAL MANAGEMENT LP |
87,609 |
1,520,000 |
1.04% |
|
|
| 20 |
SPHERA FUNDS MANAGEMENT LTD. |
70,000 |
1,215,000 |
0.83% |
|
|
| 21 |
Cormorant Asset Management, LP |
61,500 |
1,067,000 |
0.73% |
|
|
| 22 |
CITADEL ADVISORS LLC |
60,316 |
1,046,000 |
0.72% |
|
|
| 23 |
MILLENNIUM MANAGEMENT LLC |
53,121 |
922,000 |
0.63% |
|
|
| 24 |
Rock Springs Capital Management LP |
35,540 |
617,000 |
0.42% |
|
|
| 25 |
Weiss Multi-Strategy Advisers LLC |
22,000 |
382,000 |
0.26% |
|
|
| 26 |
Sterling Capital Management LLC |
19,452 |
337,000 |
0.23% |
|
|
| 27 |
PUTNAM INVESTMENTS LLC |
18,809 |
326,000 |
0.22% |
|
|
| 28 |
BANK OF AMERICA CORP /DE/ |
16,892 |
293,000 |
0.20% |
|
|
| 29 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
10,228 |
177,000 |
0.12% |
|
|
| 30 |
PERCEPTIVE ADVISORS LLC |
10,000 |
174,000 |
0.12% |
|
|
| 31 |
BlackRock Investment Management, LLC |
8,800 |
153,000 |
0.10% |
|
|
| 32 |
MORGAN STANLEY |
5,250 |
91,000 |
0.06% |
|
|
| 33 |
WELLS FARGO & COMPANY/MN |
2,575 |
45,000 |
0.03% |
|
|
| 34 |
Tower Research Capital LLC (TRC) |
1,323 |
23,000 |
0.02% |
|
|
| 35 |
UBS Group AG |
865 |
15,000 |
0.01% |
|
|
| 36 |
CITIGROUP INC |
80 |
1,000 |
0.00% |
|
|
