| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 1,913,153 | 33,825,000 | 21.43% | ||
| 2 | ORBIMED ADVISORS LLC | 1,448,991 | 25,618,000 | 16.23% | ||
| 3 | FMR LLC | 1,043,956 | 18,353,000 | 11.63% | ||
| 4 | RS INVESTMENT MANAGEMENT CO LLC | 954,270 | 16,776,000 | 10.63% | ||
| 5 | VHCP Management, LLC | 811,152 | 14,070,000 | 8.92% | ||
| 6 | ACUTA CAPITAL PARTNERS, LLC | 421,851 | 7,458,000 | 4.73% | ||
| 7 | GREAT POINT PARTNERS LLC | 311,222 | 5,502,000 | 3.49% | ||
| 8 | Visium Asset Management, LP | 255,000 | 4,483,000 | 2.84% | ||
| 9 | Rock Springs Capital Management LP | 240,000 | 4,243,000 | 2.69% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 235,560 | 4,165,000 | 2.64% | ||
| 11 | LAZARD ASSET MANAGEMENT LLC | 210,325 | 3,697,000 | 2.34% | ||
| 12 | Sio Capital Management, LLC | 202,525 | 3,581,000 | 2.27% | ||
| 13 | SABBY MANAGEMENT, LLC | 160,000 | 2,813,000 | 1.78% | ||
| 14 | SCOPIA CAPITAL MANAGEMENT LP | 148,114 | 2,604,000 | 1.65% | ||
| 15 | BAKER BROS. ADVISORS LP | 100,000 | 1,768,000 | 1.12% | ||
| 16 | DAFNA Capital Management LLC | 93,541 | 1,654,000 | 1.05% | ||
| 17 | HIGHLAND CAPITAL MANAGEMENT LP | 67,796 | 1,199,000 | 0.76% | ||
| 18 | Ghost Tree Capital, LLC | 63,739 | 1,127,000 | 0.71% | ||
| 19 | Cormorant Asset Management, LP | 61,500 | 1,087,000 | 0.69% | ||
| 20 | Alyeska Investment Group, L.P. | 60,940 | 1,077,000 | 0.68% | ||
| 21 | PICTET ASSET MANAGEMENT LTD | 31,100 | 623,000 | 0.39% | ||
| 22 | ALPS ADVISORS INC | 23,626 | 415,000 | 0.26% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 21,384 | 378,000 | 0.24% | ||
| 24 | DEERFIELD MANAGEMENT COMPANY, L.P. | 20,859 | 369,000 | 0.23% | ||
| 25 | BANK OF AMERICA CORP /DE/ | 19,280 | 341,000 | 0.22% | ||
| 26 | PUTNAM INVESTMENTS LLC | 18,809 | 331,000 | 0.21% | ||
| 27 | PERCEPTIVE ADVISORS LLC | 10,000 | 176,000 | 0.11% | ||
| 28 | PANAGORA ASSET MANAGEMENT INC | 2,264 | 40,000 | 0.03% | ||
| 29 | MORGAN STANLEY | 1,660 | 29,000 | 0.02% | ||
| 30 | UBS Group AG | 788 | 14,000 | 0.01% | ||
| 31 | ROYAL BANK OF CANADA | 183 | 3,000 | 0.00% | ||
| 32 | CITIGROUP INC | 42 | 1,000 | 0.00% | ||
| 33 | Tower Research Capital LLC (TRC) | 15 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
