| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 3,681,491 | 73,998,000 | 26.30% | ||
| 2 | FMR LLC | 2,512,824 | 50,507,000 | 17.95% | ||
| 3 | ORBIMED ADVISORS LLC | 2,191,000 | 44,039,000 | 15.65% | ||
| 4 | VIVO CAPITAL, LLC | 1,766,832 | 35,513,000 | 12.62% | ||
| 5 | BAKER BROS. ADVISORS LP | 745,521 | 14,985,000 | 5.33% | ||
| 6 | VHCP MANAGEMENT II, LLC | 721,152 | 14,495,000 | 5.15% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 647,997 | 13,025,000 | 4.63% | ||
| 8 | ACUTA CAPITAL PARTNERS, LLC | 363,000 | 7,296,000 | 2.59% | ||
| 9 | Rock Springs Capital Management LP | 300,000 | 6,030,000 | 2.14% | ||
| 10 | SPHERA FUNDS MANAGEMENT LTD. | 263,500 | 5,296,000 | 1.88% | ||
| 11 | EcoR1 Capital, LLC | 219,200 | 4,406,000 | 1.57% | ||
| 12 | NEXTHERA CAPITAL LP | 146,200 | 2,939,000 | 1.04% | ||
| 13 | Sio Capital Management, LLC | 112,497 | 2,261,000 | 0.80% | ||
| 14 | VHCP Management, LLC | 90,000 | 1,809,000 | 0.64% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 76,222 | 1,532,000 | 0.54% | ||
| 16 | Cormorant Asset Management, LP | 62,254 | 1,251,000 | 0.44% | ||
| 17 | Avoro Capital Advisors LLC | 45,203 | 909,000 | 0.32% | ||
| 18 | DAFNA Capital Management LLC | 30,750 | 618,000 | 0.22% | ||
| 19 | CREDIT SUISSE AG/ | 15,031 | 302,000 | 0.11% | ||
| 20 | BANK OF AMERICA CORP /DE/ | 3,225 | 65,000 | 0.02% | ||
| 21 | UBS Group AG | 918 | 18,000 | 0.01% | ||
| 22 | Tower Research Capital LLC (TRC) | 839 | 17,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
