| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 5,409,990 | 109,498,000 | 26.31% | ||
| 2 | FMR LLC | 3,152,532 | 63,807,000 | 15.33% | ||
| 3 | ORBIMED ADVISORS LLC | 2,717,315 | 54,998,000 | 13.22% | ||
| 4 | VIVO CAPITAL, LLC | 1,766,832 | 35,761,000 | 8.59% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,050,000 | 21,252,000 | 5.11% | ||
| 6 | BAKER BROS. ADVISORS LP | 1,023,266 | 20,711,000 | 4.98% | ||
| 7 | EcoR1 Capital, LLC | 975,700 | 19,748,000 | 4.75% | ||
| 8 | VHCP MANAGEMENT II, LLC | 721,152 | 14,596,000 | 3.51% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 594,295 | 12,029,000 | 2.89% | ||
| 10 | ACUTA CAPITAL PARTNERS, LLC | 575,309 | 11,644,000 | 2.80% | ||
| 11 | Avoro Capital Advisors LLC | 545,203 | 11,035,000 | 2.65% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 326,622 | 6,611,000 | 1.59% | ||
| 13 | Rock Springs Capital Management LP | 325,000 | 6,578,000 | 1.58% | ||
| 14 | EVENTIDE ASSET MANAGEMENT, LLC | 229,000 | 4,635,000 | 1.11% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 226,804 | 4,591,000 | 1.10% | ||
| 16 | FORESITE CAPITAL MANAGEMENT III, LLC | 180,000 | 3,643,000 | 0.88% | ||
| 17 | Cormorant Asset Management, LP | 162,254 | 3,284,000 | 0.79% | ||
| 18 | EMORY UNIVERSITY | 104,793 | 2,121,000 | 0.51% | ||
| 19 | NEXTHERA CAPITAL LP | 100,000 | 2,024,000 | 0.49% | ||
| 20 | VHCP Management, LLC | 90,000 | 1,822,000 | 0.44% | ||
| 21 | MARSHALL WACE, LLP | 87,558 | 1,772,000 | 0.43% | ||
| 22 | Laurion Capital Management LP | 83,200 | 1,684,000 | 0.40% | ||
| 23 | DAFNA Capital Management LLC | 53,000 | 1,073,000 | 0.26% | ||
| 24 | ALPS ADVISORS INC | 30,296 | 613,000 | 0.15% | ||
| 25 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 20,000 | 405,000 | 0.10% | ||
| 26 | WELLS FARGO & COMPANY/MN | 5,247 | 106,000 | 0.03% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 4,325 | 88,000 | 0.02% | ||
| 28 | MORGAN STANLEY | 662 | 13,000 | 0.00% | ||
| 29 | Tower Research Capital LLC (TRC) | 609 | 12,000 | 0.00% | ||
| 30 | UBS Group AG | 200 | 4,000 | 0.00% | ||
| 31 | US BANCORP \DE\ | 76 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
