| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,296,441 | 42,599,000 | 19.08% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 2,161,366 | 40,093,000 | 17.96% | ||
| 3 | VIVO CAPITAL, LLC | 1,419,332 | 26,329,000 | 11.79% | ||
| 4 | Visium Asset Management, LP | 1,407,350 | 26,106,000 | 11.69% | ||
| 5 | RS INVESTMENT MANAGEMENT CO LLC | 985,849 | 18,287,000 | 8.19% | ||
| 6 | VHCP MANAGEMENT II, LLC | 721,152 | 13,377,000 | 5.99% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 670,007 | 12,429,000 | 5.57% | ||
| 8 | ACUTA CAPITAL PARTNERS, LLC | 623,631 | 11,568,000 | 5.18% | ||
| 9 | BAKER BROS. ADVISORS LP | 505,521 | 9,377,000 | 4.20% | ||
| 10 | Rock Springs Capital Management LP | 270,000 | 5,009,000 | 2.24% | ||
| 11 | ORBIMED ADVISORS LLC | 222,223 | 4,122,000 | 1.85% | ||
| 12 | LAZARD ASSET MANAGEMENT LLC | 193,050 | 3,581,000 | 1.60% | ||
| 13 | Sio Capital Management, LLC | 187,220 | 3,473,000 | 1.56% | ||
| 14 | VHCP Management, LLC | 90,000 | 1,670,000 | 0.75% | ||
| 15 | Cormorant Asset Management, LP | 61,500 | 1,141,000 | 0.51% | ||
| 16 | DAFNA Capital Management LLC | 53,241 | 988,000 | 0.44% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 31,100 | 577,000 | 0.26% | ||
| 18 | PICTET ASSET MANAGEMENT LTD | 31,100 | 540,000 | 0.24% | ||
| 19 | ALPS ADVISORS INC | 28,259 | 524,000 | 0.23% | ||
| 20 | MORGAN STANLEY | 25,759 | 478,000 | 0.21% | ||
| 21 | BANK OF AMERICA CORP /DE/ | 22,311 | 414,000 | 0.19% | ||
| 22 | GSA CAPITAL PARTNERS LLP | 18,700 | 347,000 | 0.16% | ||
| 23 | CREDIT SUISSE AG/ | 10,016 | 186,000 | 0.08% | ||
| 24 | UBS Group AG | 1,417 | 26,000 | 0.01% | ||
| 25 | DEUTSCHE BANK AG\ | 79 | 1,000 | 0.00% | ||
| 26 | CITIGROUP INC | 50 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
