| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,310,741 | 42,333,000 | 22.90% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 1,671,447 | 30,621,000 | 16.56% | ||
| 3 | Visium Asset Management, LP | 1,370,000 | 25,098,000 | 13.58% | ||
| 4 | RS INVESTMENT MANAGEMENT CO LLC | 979,061 | 17,936,000 | 9.70% | ||
| 5 | VHCP MANAGEMENT II, LLC | 721,152 | 13,212,000 | 7.15% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 701,916 | 12,859,000 | 6.96% | ||
| 7 | ACUTA CAPITAL PARTNERS, LLC | 519,243 | 9,513,000 | 5.15% | ||
| 8 | BAKER BROS. ADVISORS LP | 505,521 | 9,261,000 | 5.01% | ||
| 9 | Sio Capital Management, LLC | 284,785 | 5,217,000 | 2.82% | ||
| 10 | Rock Springs Capital Management LP | 270,000 | 4,946,000 | 2.68% | ||
| 11 | ORBIMED ADVISORS LLC | 222,223 | 4,071,000 | 2.20% | ||
| 12 | LAZARD ASSET MANAGEMENT LLC | 193,050 | 3,536,000 | 1.91% | ||
| 13 | VHCP Management, LLC | 90,000 | 1,649,000 | 0.89% | ||
| 14 | Cormorant Asset Management, LP | 61,500 | 1,127,000 | 0.61% | ||
| 15 | DAFNA Capital Management LLC | 53,241 | 975,000 | 0.53% | ||
| 16 | ALPS ADVISORS INC | 33,102 | 606,000 | 0.33% | ||
| 17 | PICTET ASSET MANAGEMENT LTD | 31,100 | 570,000 | 0.31% | ||
| 18 | SECTORAL ASSET MANAGEMENT INC | 31,100 | 570,000 | 0.31% | ||
| 19 | BANK OF AMERICA CORP /DE/ | 20,859 | 382,000 | 0.21% | ||
| 20 | CREDIT SUISSE AG/ | 11,220 | 205,000 | 0.11% | ||
| 21 | DEUTSCHE BANK AG\ | 4,318 | 79,000 | 0.04% | ||
| 22 | MORGAN STANLEY | 2,851 | 52,000 | 0.03% | ||
| 23 | UBS Group AG | 1,404 | 26,000 | 0.01% | ||
| 24 | CITADEL ADVISORS LLC | 1,156 | 21,000 | 0.01% | ||
| 25 | ROYAL BANK OF CANADA | 6 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
