| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,538,892 | 21,708,000 | 18.06% | ||
| 2 | FRANKLIN RESOURCES INC | 1,449,073 | 12,390,000 | 10.31% | ||
| 3 | BlackRock Finance, Inc. | 1,214,893 | 10,387,000 | 8.64% | ||
| 4 | FARALLON CAPITAL MANAGEMENT LLC | 1,167,500 | 9,982,000 | 8.31% | ||
| 5 | EVENTIDE ASSET MANAGEMENT, LLC | 1,086,400 | 9,289,000 | 7.73% | ||
| 6 | VANGUARD GROUP INC | 825,153 | 7,055,000 | 5.87% | ||
| 7 | BAKER BROS. ADVISORS LP | 633,497 | 5,416,000 | 4.51% | ||
| 8 | AXA S.A. | 434,183 | 3,712,000 | 3.09% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 428,223 | 3,661,000 | 3.05% | ||
| 10 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 330,000 | 2,805,000 | 2.33% | ||
| 11 | STATE STREET CORP | 310,247 | 2,653,000 | 2.21% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 300,000 | 2,565,000 | 2.13% | ||
| 13 | SABBY MANAGEMENT, LLC | 290,087 | 2,480,000 | 2.06% | ||
| 14 | NORTHERN TRUST CORP | 232,926 | 1,992,000 | 1.66% | ||
| 15 | VHCP MANAGEMENT II, LLC | 228,130 | 1,951,000 | 1.62% | ||
| 16 | Ghost Tree Capital, LLC | 225,000 | 1,924,000 | 1.60% | ||
| 17 | COLUMBUS CIRCLE INVESTORS | 214,816 | 1,837,000 | 1.53% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 159,920 | 1,367,000 | 1.14% | ||
| 19 | J. Goldman & Co LP | 140,000 | 1,197,000 | 1.00% | ||
| 20 | BAILARD, INC. | 138,785 | 1,187,000 | 0.99% | ||
| 21 | DEUTSCHE BANK AG\ | 120,050 | 1,025,000 | 0.85% | ||
| 22 | Artal Group S.A. | 100,000 | 855,000 | 0.71% | ||
| 23 | PANAGORA ASSET MANAGEMENT INC | 98,283 | 840,000 | 0.70% | ||
| 24 | Bank of New York Mellon Corp | 87,091 | 745,000 | 0.62% | ||
| 25 | COWEN INC. | 76,900 | 657,000 | 0.55% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,746 | 648,000 | 0.54% | ||
| 27 | DIMENSIONAL FUND ADVISORS LP | 68,899 | 589,000 | 0.49% | ||
| 28 | HAP Trading, LLC | 65,387 | 559,000 | 0.47% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,200 | 540,000 | 0.45% | Call | |
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 62,199 | 532,000 | 0.44% | ||
| 31 | PURA VIDA INVESTMENTS, LLC | 60,000 | 513,000 | 0.43% | ||
| 32 | Trexquant Investment LP | 57,311 | 490,000 | 0.41% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,300 | 490,000 | 0.41% | Put | |
| 34 | AMERIPRISE FINANCIAL INC | 43,900 | 375,000 | 0.31% | ||
| 35 | TEACHERS ADVISORS, LLC | 42,856 | 366,000 | 0.30% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,149 | 360,000 | 0.30% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,200 | 344,000 | 0.29% | ||
| 38 | OAK RIDGE INVESTMENTS LLC | 36,208 | 310,000 | 0.26% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 35,916 | 307,000 | 0.26% | ||
| 40 | A.R.T. Advisors, LLC | 35,038 | 299,000 | 0.25% | ||
| 41 | HAP Trading, LLC | 104,700 | 288,000 | 0.24% | Put | |
| 42 | MORGAN STANLEY | 31,958 | 274,000 | 0.23% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 31,100 | 266,000 | 0.22% | ||
| 44 | UBS Group AG | 26,945 | 230,000 | 0.19% | ||
| 45 | CARL DOMINO INC | 26,000 | 222,000 | 0.18% | ||
| 46 | AQR CAPITAL MANAGEMENT LLC | 25,562 | 219,000 | 0.18% | ||
| 47 | STONERIDGE INVESTMENT PARTNERS LLC | 25,323 | 217,000 | 0.18% | ||
| 48 | Telemetry Investments, L.L.C. | 23,530 | 201,000 | 0.17% | ||
| 49 | RHUMBLINE ADVISERS | 23,078 | 197,000 | 0.16% | ||
| 50 | Opus Point Partners Management, LLC | 20,595 | 176,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
