| # | % | |||||
|---|---|---|---|---|---|---|
| 51 | TIAA CREF INVESTMENT MANAGEMENT LLC | 62,199 | 532,000 | 0.44% | ||
| 52 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,200 | 540,000 | 0.45% | Call | |
| 53 | HAP Trading, LLC | 65,387 | 559,000 | 0.47% | ||
| 54 | DIMENSIONAL FUND ADVISORS LP | 68,899 | 589,000 | 0.49% | ||
| 55 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,746 | 648,000 | 0.54% | ||
| 56 | COWEN INC. | 76,900 | 657,000 | 0.55% | ||
| 57 | Bank of New York Mellon Corp | 87,091 | 745,000 | 0.62% | ||
| 58 | PANAGORA ASSET MANAGEMENT INC | 98,283 | 840,000 | 0.70% | ||
| 59 | Artal Group S.A. | 100,000 | 855,000 | 0.71% | ||
| 60 | DEUTSCHE BANK AG\ | 120,050 | 1,025,000 | 0.85% | ||
| 61 | BAILARD, INC. | 138,785 | 1,187,000 | 0.99% | ||
| 62 | J. Goldman & Co LP | 140,000 | 1,197,000 | 1.00% | ||
| 63 | GEODE CAPITAL MANAGEMENT, LLC | 159,920 | 1,367,000 | 1.14% | ||
| 64 | COLUMBUS CIRCLE INVESTORS | 214,816 | 1,837,000 | 1.53% | ||
| 65 | Ghost Tree Capital, LLC | 225,000 | 1,924,000 | 1.60% | ||
| 66 | VHCP MANAGEMENT II, LLC | 228,130 | 1,951,000 | 1.62% | ||
| 67 | NORTHERN TRUST CORP | 232,926 | 1,992,000 | 1.66% | ||
| 68 | SABBY MANAGEMENT, LLC | 290,087 | 2,480,000 | 2.06% | ||
| 69 | SPHERA FUNDS MANAGEMENT LTD. | 300,000 | 2,565,000 | 2.13% | ||
| 70 | STATE STREET CORP | 310,247 | 2,653,000 | 2.21% | ||
| 71 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 330,000 | 2,805,000 | 2.33% | ||
| 72 | MILLENNIUM MANAGEMENT LLC | 428,223 | 3,661,000 | 3.05% | ||
| 73 | AXA S.A. | 434,183 | 3,712,000 | 3.09% | ||
| 74 | BAKER BROS. ADVISORS LP | 633,497 | 5,416,000 | 4.51% | ||
| 75 | VANGUARD GROUP INC | 825,153 | 7,055,000 | 5.87% | ||
| 76 | EVENTIDE ASSET MANAGEMENT, LLC | 1,086,400 | 9,289,000 | 7.73% | ||
| 77 | FARALLON CAPITAL MANAGEMENT LLC | 1,167,500 | 9,982,000 | 8.31% | ||
| 78 | BlackRock Finance, Inc. | 1,214,893 | 10,387,000 | 8.64% | ||
| 79 | FRANKLIN RESOURCES INC | 1,449,073 | 12,390,000 | 10.31% | ||
| 80 | FMR LLC | 2,538,892 | 21,708,000 | 18.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
