| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,511,441 | 56,261,000 | 19.48% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 4,869,261 | 32,186,000 | 11.14% | ||
| 3 | Visium Asset Management, LP | 4,526,750 | 29,922,000 | 10.36% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,500,800 | 23,140,000 | 8.01% | ||
| 5 | FRANKLIN RESOURCES INC | 1,853,900 | 12,254,000 | 4.24% | ||
| 6 | FARALLON CAPITAL MANAGEMENT LLC | 1,600,000 | 10,576,000 | 3.66% | ||
| 7 | PALISADE CAPITAL MANAGEMENT, LP | 1,379,278 | 9,117,000 | 3.16% | ||
| 8 | VANGUARD GROUP INC | 1,259,443 | 8,325,000 | 2.88% | ||
| 9 | ORBIMED ADVISORS LLC | 1,200,000 | 7,932,000 | 2.75% | ||
| 10 | BlackRock Fund Advisors | 1,034,564 | 6,838,000 | 2.37% | ||
| 11 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 796,200 | 5,263,000 | 1.82% | ||
| 12 | HealthCor Management, L.P. | 690,000 | 4,561,000 | 1.58% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 623,000 | 4,118,000 | 1.43% | Call | |
| 14 | AXA S.A. | 614,934 | 4,065,000 | 1.41% | ||
| 15 | ALYDAR PARTNERS LLC | 550,565 | 3,639,000 | 1.26% | ||
| 16 | SAC Capital Advisors LP | 502,900 | 3,324,000 | 1.15% | ||
| 17 | FEDERATED HERMES, INC. | 475,000 | 3,140,000 | 1.09% | ||
| 18 | DEERFIELD MANAGEMENT COMPANY, L.P. | 455,741 | 3,012,000 | 1.04% | ||
| 19 | STIFEL FINANCIAL CORP | 427,512 | 2,826,000 | 0.98% | ||
| 20 | STATE STREET CORP | 427,307 | 2,826,000 | 0.98% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 421,870 | 2,789,000 | 0.97% | ||
| 22 | NORTHERN TRUST CORP | 420,120 | 2,777,000 | 0.96% | ||
| 23 | PRINCIPAL FINANCIAL GROUP INC | 360,640 | 2,383,000 | 0.83% | ||
| 24 | PointState Capital LP | 350,000 | 2,314,000 | 0.80% | ||
| 25 | BLACKROCK ADVISORS LLC | 342,540 | 2,264,000 | 0.78% | ||
| 26 | SIGMA CAPITAL MANAGEMENT LLC | 320,000 | 2,115,000 | 0.73% | ||
| 27 | D. E. Shaw & Co., Inc. | 278,268 | 1,839,000 | 0.64% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 267,441 | 1,768,000 | 0.61% | ||
| 29 | UBS AG | 259,410 | 1,715,000 | 0.59% | ||
| 30 | I.G. INVESTMENT MANAGEMENT, LTD. | 232,000 | 1,534,000 | 0.53% | ||
| 31 | First Eagle Investment Management, LLC | 219,557 | 1,451,000 | 0.50% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 215,400 | 1,424,000 | 0.49% | Put | |
| 33 | SMITH ASSET MANAGEMENT GROUP LP | 213,433 | 1,411,000 | 0.49% | ||
| 34 | GREAT POINT PARTNERS LLC | 193,567 | 1,279,000 | 0.44% | ||
| 35 | J. Goldman & Co LP | 190,000 | 1,256,000 | 0.43% | Call | |
| 36 | ESSEX INVESTMENT MANAGEMENT CO LLC | 188,803 | 1,248,000 | 0.43% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 180,667 | 1,194,000 | 0.41% | ||
| 38 | Bank of New York Mellon Corp | 171,137 | 1,131,000 | 0.39% | ||
| 39 | BANK OF MONTREAL /CAN/ | 165,200 | 1,092,000 | 0.38% | Put | |
| 40 | Informed Momentum Co LLC | 162,383 | 1,073,000 | 0.37% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 167,962 | 1,016,000 | 0.35% | ||
| 42 | Rhenman & Partners Asset Management AB | 147,403 | 974,000 | 0.34% | ||
| 43 | AMERIPRISE FINANCIAL INC | 141,175 | 933,000 | 0.32% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 138,728 | 917,000 | 0.32% | ||
| 45 | MANAGED ACCOUNT ADVISORS LLC | 138,394 | 914,000 | 0.32% | ||
| 46 | TFS CAPITAL LLC | 134,182 | 887,000 | 0.31% | ||
| 47 | MUNDER CAPITAL MANAGEMENT | 128,768 | 851,000 | 0.29% | ||
| 48 | PUTNAM INVESTMENTS LLC | 114,581 | 757,000 | 0.26% | ||
| 49 | TD ASSET MANAGEMENT INC | 107,800 | 713,000 | 0.25% | ||
| 50 | BlackRock Investment Management, LLC | 103,406 | 684,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
