| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,943,861 | 63,860,000 | 16.08% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,235,500 | 44,521,000 | 11.21% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 4,869,261 | 34,767,000 | 8.76% | ||
| 4 | Visium Asset Management, LP | 4,093,890 | 29,230,000 | 7.36% | ||
| 5 | CITADEL ADVISORS LLC | 3,258,099 | 23,263,000 | 5.86% | ||
| 6 | EAGLE ASSET MANAGEMENT INC | 2,342,041 | 16,722,000 | 4.21% | ||
| 7 | VANGUARD GROUP INC | 1,456,988 | 10,403,000 | 2.62% | ||
| 8 | Lamond Capital Partners LLC | 1,320,000 | 9,425,000 | 2.37% | ||
| 9 | FRANKLIN RESOURCES INC | 1,313,300 | 9,377,000 | 2.36% | ||
| 10 | ORBIMED ADVISORS LLC | 1,200,000 | 8,568,000 | 2.16% | ||
| 11 | BlackRock Fund Advisors | 1,187,555 | 8,479,000 | 2.14% | ||
| 12 | PALISADE CAPITAL MANAGEMENT, LP | 1,130,661 | 8,073,000 | 2.03% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,108,700 | 7,916,000 | 1.99% | Call | |
| 14 | BARCLAYS PLC | 911,000 | 6,377,000 | 1.61% | Put | |
| 15 | UBS AG | 745,547 | 5,323,000 | 1.34% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 706,900 | 5,047,000 | 1.27% | Put | |
| 17 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 552,100 | 3,942,000 | 0.99% | ||
| 18 | STATE STREET CORP | 546,682 | 3,902,000 | 0.98% | ||
| 19 | HealthCor Management, L.P. | 532,500 | 3,802,000 | 0.96% | ||
| 20 | NORTHERN TRUST CORP | 529,135 | 3,778,000 | 0.95% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 516,800 | 3,690,000 | 0.93% | Put | |
| 22 | BlackRock Institutional Trust Company, N.A. | 473,705 | 3,382,000 | 0.85% | ||
| 23 | GOLDMAN SACHS GROUP INC | 454,800 | 3,247,000 | 0.82% | Call | |
| 24 | AXA S.A. | 436,975 | 3,120,000 | 0.79% | ||
| 25 | MANAGED ACCOUNT ADVISORS LLC | 405,407 | 2,894,000 | 0.73% | ||
| 26 | PERCEPTIVE ADVISORS LLC | 400,000 | 2,856,000 | 0.72% | Put | |
| 27 | GREAT POINT PARTNERS LLC | 400,000 | 2,856,000 | 0.72% | Call | |
| 28 | PERCEPTIVE ADVISORS LLC | 400,000 | 2,856,000 | 0.72% | Call | |
| 29 | STIFEL FINANCIAL CORP | 367,324 | 2,623,000 | 0.66% | ||
| 30 | PRINCIPAL FINANCIAL GROUP INC | 364,381 | 2,602,000 | 0.66% | ||
| 31 | ESSEX INVESTMENT MANAGEMENT CO LLC | 354,861 | 2,534,000 | 0.64% | ||
| 32 | ORBIMED ADVISORS LLC | 350,000 | 2,499,000 | 0.63% | Call | |
| 33 | Bank of New York Mellon Corp | 338,760 | 2,419,000 | 0.61% | ||
| 34 | Informed Momentum Co LLC | 277,807 | 1,984,000 | 0.50% | ||
| 35 | AMERIPRISE FINANCIAL INC | 243,543 | 1,739,000 | 0.44% | ||
| 36 | FEDERATED HERMES, INC. | 230,900 | 1,649,000 | 0.42% | ||
| 37 | DEERFIELD MANAGEMENT COMPANY, L.P. | 223,625 | 1,597,000 | 0.40% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 211,529 | 1,510,000 | 0.38% | ||
| 39 | SMITH ASSET MANAGEMENT GROUP LP | 203,128 | 1,450,000 | 0.37% | ||
| 40 | Rhenman & Partners Asset Management AB | 201,171 | 1,436,000 | 0.36% | ||
| 41 | RUSSELL FRANK CO/ | 199,608 | 1,426,000 | 0.36% | ||
| 42 | UBS AG | 199,500 | 1,424,000 | 0.36% | Call | |
| 43 | BARCLAYS PLC | 187,700 | 1,314,000 | 0.33% | Call | |
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 180,067 | 1,286,000 | 0.32% | ||
| 45 | TWO SIGMA INVESTMENTS, LP | 176,777 | 1,262,000 | 0.32% | ||
| 46 | DSC Advisors, L.P. | 175,000 | 1,250,000 | 0.31% | ||
| 47 | UBS AG | 164,700 | 1,176,000 | 0.30% | Put | |
| 48 | MILLENNIUM MANAGEMENT LLC | 150,000 | 1,071,000 | 0.27% | Call | |
| 49 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 146,600 | 1,047,000 | 0.26% | Call | |
| 50 | BlackRock Investment Management, LLC | 144,634 | 1,033,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
