| 1 |
PRICE T ROWE ASSOCIATES INC /MD/ |
5,670,000 |
14,459,000 |
14.37% |
|
|
| 2 |
FMR LLC |
5,083,834 |
12,964,000 |
12.88% |
|
|
| 3 |
BAKER BROS. ADVISORS LP |
3,200,000 |
8,160,000 |
8.11% |
|
|
| 4 |
BVF INC/IL |
3,136,000 |
7,997,000 |
7.95% |
|
|
| 5 |
CITADEL ADVISORS LLC |
2,575,572 |
6,568,000 |
6.53% |
|
|
| 6 |
BALYASNY ASSET MANAGEMENT L.P. |
2,346,948 |
5,985,000 |
5.95% |
|
|
| 7 |
VANGUARD GROUP INC |
1,611,555 |
4,110,000 |
4.08% |
|
|
| 8 |
Visium Asset Management, LP |
1,528,356 |
3,898,000 |
3.87% |
|
|
| 9 |
First Eagle Investment Management, LLC |
1,414,276 |
3,606,000 |
3.58% |
|
|
| 10 |
BlackRock Fund Advisors |
1,379,779 |
3,518,000 |
3.50% |
|
|
| 11 |
MORGAN STANLEY |
1,008,598 |
2,572,000 |
2.56% |
|
|
| 12 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
852,100 |
2,173,000 |
2.16% |
|
|
| 13 |
MILLENNIUM MANAGEMENT LLC |
785,000 |
2,002,000 |
1.99% |
|
|
| 14 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
778,300 |
1,985,000 |
1.97% |
|
|
| 15 |
D. E. Shaw & Co., Inc. |
764,890 |
1,951,000 |
1.94% |
|
|
| 16 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
653,970 |
1,668,000 |
1.66% |
|
|
| 17 |
STATE STREET CORP |
644,126 |
1,643,000 |
1.63% |
|
|
| 18 |
NORTHERN TRUST CORP |
511,317 |
1,304,000 |
1.30% |
|
|
| 19 |
PERCEPTIVE ADVISORS LLC |
500,000 |
1,275,000 |
1.27% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
456,319 |
1,164,000 |
1.16% |
|
|
| 21 |
UBS Group AG |
343,580 |
876,000 |
0.87% |
|
|
| 22 |
PRINCIPAL FINANCIAL GROUP INC |
336,025 |
857,000 |
0.85% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
236,523 |
603,000 |
0.60% |
|
|
| 24 |
DSC Advisors, L.P. |
225,000 |
574,000 |
0.57% |
|
|
| 25 |
Bank of New York Mellon Corp |
212,378 |
542,000 |
0.54% |
|
|
| 26 |
Healthcare Value Capital, LLC |
200,000 |
510,000 |
0.51% |
|
|
| 27 |
FEDERATED HERMES, INC. |
200,000 |
510,000 |
0.51% |
|
|
| 28 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
191,900 |
489,000 |
0.49% |
Put |
|
| 29 |
Alden Global Capital Ltd |
188,200 |
480,000 |
0.48% |
|
|
| 30 |
UBS Group AG |
175,500 |
448,000 |
0.45% |
Call |
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
174,965 |
446,000 |
0.44% |
|
|
| 32 |
BlackRock Investment Management, LLC |
145,060 |
370,000 |
0.37% |
|
|
| 33 |
TD ASSET MANAGEMENT INC |
133,600 |
341,000 |
0.34% |
|
|
| 34 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
126,201 |
322,000 |
0.32% |
|
|
| 35 |
CREDIT SUISSE AG/ |
124,421 |
317,000 |
0.31% |
|
|
| 36 |
GOLDMAN SACHS GROUP INC |
123,876 |
316,000 |
0.31% |
|
|
| 37 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
110,100 |
281,000 |
0.28% |
Call |
|
| 38 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
116,500 |
276,000 |
0.27% |
|
|
| 39 |
Nationwide Fund Advisors |
103,112 |
263,000 |
0.26% |
|
|
| 40 |
AMERICAN INTERNATIONAL GROUP, INC. |
95,751 |
244,165 |
0.24% |
|
|
| 41 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
91,771 |
234,000 |
0.23% |
|
|
| 42 |
BANK OF AMERICA CORP /DE/ |
80,446 |
205,000 |
0.20% |
|
|
| 43 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
72,600 |
186,000 |
0.18% |
|
|
| 44 |
TEACHERS ADVISORS, LLC |
68,780 |
175,000 |
0.17% |
|
|
| 45 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
60,263 |
154,000 |
0.15% |
|
|
| 46 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
52,923 |
135,000 |
0.13% |
|
|
| 47 |
Weiss Multi-Strategy Advisers LLC |
50,000 |
128,000 |
0.13% |
|
|
| 48 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
41,800 |
107,000 |
0.11% |
|
|
| 49 |
GROUP ONE TRADING LLC |
41,626 |
106,000 |
0.11% |
|
|
| 50 |
RHUMBLINE ADVISERS |
41,173 |
105,000 |
0.10% |
|
|
