| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,083,834 | 15,302,000 | 12.33% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,941,700 | 14,875,000 | 11.99% | ||
| 3 | Visium Asset Management, LP | 3,325,000 | 10,008,000 | 8.07% | ||
| 4 | BAKER BROS. ADVISORS LP | 3,200,000 | 9,632,000 | 7.76% | ||
| 5 | GREAT POINT PARTNERS LLC | 2,541,459 | 7,650,000 | 6.17% | ||
| 6 | FARALLON CAPITAL MANAGEMENT LLC | 2,163,222 | 6,511,000 | 5.25% | ||
| 7 | VANGUARD GROUP INC | 1,724,242 | 5,190,000 | 4.18% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 1,382,884 | 4,162,000 | 3.35% | ||
| 9 | BALYASNY ASSET MANAGEMENT L.P. | 1,380,704 | 4,156,000 | 3.35% | ||
| 10 | Ghost Tree Capital, LLC | 1,250,000 | 3,763,000 | 3.03% | ||
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 1,235,000 | 3,717,000 | 3.00% | ||
| 12 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,082,211 | 3,257,000 | 2.62% | ||
| 13 | Palo Alto Investors LP | 906,263 | 2,728,000 | 2.20% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 768,800 | 2,314,000 | 1.86% | Call | |
| 15 | PERCEPTIVE ADVISORS LLC | 700,000 | 2,107,000 | 1.70% | ||
| 16 | Healthcare Value Capital, LLC | 700,000 | 2,107,000 | 1.70% | Call | |
| 17 | ALLIANCEBERNSTEIN L.P. | 669,770 | 2,016,000 | 1.62% | ||
| 18 | GOLDMAN SACHS GROUP INC | 566,120 | 1,704,000 | 1.37% | ||
| 19 | D. E. Shaw & Co., Inc. | 525,173 | 1,580,000 | 1.27% | ||
| 20 | NORTHERN TRUST CORP | 481,301 | 1,449,000 | 1.17% | ||
| 21 | MORGAN STANLEY | 464,448 | 1,398,000 | 1.13% | ||
| 22 | ASCEND CAPITAL, LLC | 448,000 | 1,348,000 | 1.09% | ||
| 23 | FEDERATED HERMES, INC. | 400,000 | 1,204,000 | 0.97% | ||
| 24 | PRINCIPAL FINANCIAL GROUP INC | 371,216 | 1,117,000 | 0.90% | ||
| 25 | Frontier Wealth Management LLC | 342,920 | 1,032,000 | 0.83% | ||
| 26 | Endurant Capital Management LP | 288,400 | 868,000 | 0.70% | ||
| 27 | Polar Capital LLP | 275,000 | 828,000 | 0.67% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 252,239 | 759,000 | 0.61% | ||
| 29 | SABBY MANAGEMENT, LLC | 245,112 | 738,000 | 0.59% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 244,700 | 737,000 | 0.59% | Put | |
| 31 | DSC Advisors, L.P. | 225,000 | 677,000 | 0.55% | ||
| 32 | ASCEND CAPITAL, LLC | 208,900 | 630,000 | 0.51% | Call | |
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 203,880 | 613,000 | 0.49% | ||
| 34 | Healthcare Value Capital, LLC | 200,000 | 602,000 | 0.49% | ||
| 35 | GROUP ONE TRADING LLC | 187,428 | 564,000 | 0.45% | ||
| 36 | CREDIT SUISSE AG/ | 180,545 | 543,000 | 0.44% | ||
| 37 | BlackRock Fund Advisors | 152,003 | 458,000 | 0.37% | ||
| 38 | Nationwide Fund Advisors | 150,400 | 453,000 | 0.37% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 138,402 | 417,000 | 0.34% | ||
| 40 | DEUTSCHE BANK AG\ | 135,676 | 408,000 | 0.33% | ||
| 41 | TD ASSET MANAGEMENT INC | 133,600 | 402,000 | 0.32% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 116,500 | 351,000 | 0.28% | ||
| 43 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 107,228 | 323,000 | 0.26% | ||
| 44 | JPMORGAN CHASE & CO | 100,077 | 301,000 | 0.24% | ||
| 45 | Paloma Partners Management Co | 92,400 | 278,000 | 0.22% | ||
| 46 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 76,204 | 230,000 | 0.19% | ||
| 47 | DSC Advisors, L.P. | 400,000 | 208,000 | 0.17% | Call | |
| 48 | Quantitative Systematic Strategies LLC | 67,368 | 196,000 | 0.16% | ||
| 49 | Bank of New York Mellon Corp | 58,941 | 177,000 | 0.14% | ||
| 50 | Weiss Multi-Strategy Advisers LLC | 56,000 | 169,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
