| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,395,800 | 13,220,000 | 12.61% | ||
| 2 | FMR LLC | 5,083,834 | 12,455,000 | 11.88% | ||
| 3 | BAKER BROS. ADVISORS LP | 3,200,000 | 7,840,000 | 7.48% | ||
| 4 | Visium Asset Management, LP | 3,000,000 | 7,350,000 | 7.01% | ||
| 5 | BVF INC/IL | 1,893,030 | 4,638,000 | 4.42% | ||
| 6 | Ghost Tree Capital, LLC | 1,750,000 | 4,288,000 | 4.09% | ||
| 7 | VANGUARD GROUP INC | 1,719,290 | 4,212,000 | 4.02% | ||
| 8 | BALYASNY ASSET MANAGEMENT L.P. | 1,488,627 | 3,647,000 | 3.48% | ||
| 9 | BlackRock Fund Advisors | 1,473,843 | 3,611,000 | 3.44% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,319,750 | 3,233,000 | 3.08% | ||
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 1,300,000 | 3,185,000 | 3.04% | ||
| 12 | GREAT POINT PARTNERS LLC | 1,038,652 | 2,545,000 | 2.43% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 760,700 | 1,864,000 | 1.78% | Put | |
| 14 | STATE STREET CORP | 736,648 | 1,806,000 | 1.72% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 702,288 | 1,721,000 | 1.64% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 700,000 | 1,715,000 | 1.64% | ||
| 17 | DRIEHAUS CAPITAL MANAGEMENT LLC | 644,986 | 1,580,000 | 1.51% | ||
| 18 | MORGAN STANLEY | 618,034 | 1,514,000 | 1.44% | ||
| 19 | Palo Alto Investors LP | 603,400 | 1,478,000 | 1.41% | ||
| 20 | First Eagle Investment Management, LLC | 587,976 | 1,441,000 | 1.37% | ||
| 21 | D. E. Shaw & Co., Inc. | 534,321 | 1,309,000 | 1.25% | ||
| 22 | NORTHERN TRUST CORP | 511,894 | 1,254,000 | 1.20% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 506,043 | 1,240,000 | 1.18% | ||
| 24 | ASCEND CAPITAL, LLC | 500,000 | 1,225,000 | 1.17% | ||
| 25 | ALLIANCEBERNSTEIN L.P. | 451,090 | 1,105,000 | 1.05% | ||
| 26 | J. Goldman & Co LP | 400,000 | 980,000 | 0.93% | Call | |
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 384,000 | 941,000 | 0.90% | ||
| 28 | PRINCIPAL FINANCIAL GROUP INC | 338,025 | 828,000 | 0.79% | ||
| 29 | UBS Group AG | 326,248 | 799,000 | 0.76% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 314,500 | 771,000 | 0.74% | Call | |
| 31 | FEDERATED HERMES, INC. | 300,000 | 735,000 | 0.70% | ||
| 32 | SABBY MANAGEMENT, LLC | 274,800 | 673,000 | 0.64% | ||
| 33 | GOLDMAN SACHS GROUP INC | 252,500 | 619,000 | 0.59% | Call | |
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 250,946 | 614,000 | 0.59% | ||
| 35 | DSC Advisors, L.P. | 225,000 | 551,000 | 0.53% | ||
| 36 | Bank of New York Mellon Corp | 211,584 | 518,000 | 0.49% | ||
| 37 | Healthcare Value Capital, LLC | 200,000 | 490,000 | 0.47% | Call | |
| 38 | Healthcare Value Capital, LLC | 200,000 | 490,000 | 0.47% | ||
| 39 | ASCEND CAPITAL, LLC | 200,000 | 489,000 | 0.47% | Call | |
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 189,251 | 464,000 | 0.44% | ||
| 41 | BlackRock Investment Management, LLC | 164,374 | 403,000 | 0.38% | ||
| 42 | Quantitative Systematic Strategies LLC | 163,265 | 400,000 | 0.38% | ||
| 43 | Endurant Capital Management LP | 140,000 | 343,000 | 0.33% | ||
| 44 | TD ASSET MANAGEMENT INC | 133,600 | 327,000 | 0.31% | ||
| 45 | GOLDMAN SACHS GROUP INC | 128,737 | 315,000 | 0.30% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 114,928 | 282,000 | 0.27% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 116,500 | 276,000 | 0.26% | ||
| 48 | CITADEL ADVISORS LLC | 106,928 | 262,000 | 0.25% | ||
| 49 | GROUP ONE TRADING LLC | 104,219 | 255,000 | 0.24% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 103,071 | 253,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
