| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Palo Alto Investors LP | 6,974,854 | 5,650,000 | 17.60% | ||
| 2 | NEA Management Company, LLC | 5,689,644 | 4,609,000 | 14.35% | ||
| 3 | FMR LLC | 5,083,834 | 4,118,000 | 12.82% | ||
| 4 | GREAT POINT PARTNERS LLC | 3,250,000 | 2,633,000 | 8.20% | ||
| 5 | BAKER BROS. ADVISORS LP | 3,200,000 | 2,592,000 | 8.07% | ||
| 6 | FARALLON CAPITAL MANAGEMENT LLC | 3,075,461 | 2,491,000 | 7.76% | ||
| 7 | BVF INC/IL | 2,500,000 | 2,025,000 | 6.31% | ||
| 8 | VANGUARD GROUP INC | 2,013,821 | 1,631,000 | 5.08% | ||
| 9 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,196,604 | 969,000 | 3.02% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 700,000 | 567,000 | 1.77% | ||
| 11 | Frontier Wealth Management LLC | 554,020 | 449,000 | 1.40% | ||
| 12 | Healthcare Value Capital, LLC | 450,000 | 365,000 | 1.14% | Call | |
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 424,308 | 344,000 | 1.07% | ||
| 14 | FEDERATED HERMES, INC. | 400,000 | 324,000 | 1.01% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 376,983 | 305,000 | 0.95% | ||
| 16 | Quantitative Systematic Strategies LLC | 333,457 | 305,000 | 0.95% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 339,722 | 275,000 | 0.86% | ||
| 18 | Ghost Tree Capital, LLC | 292,939 | 237,000 | 0.74% | ||
| 19 | MORGAN STANLEY | 239,711 | 193,000 | 0.60% | ||
| 20 | TFS CAPITAL LLC | 230,380 | 187,000 | 0.58% | ||
| 21 | ASCEND CAPITAL, LLC | 208,900 | 169,000 | 0.53% | Call | |
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 202,500 | 164,000 | 0.51% | Call | |
| 23 | Endurant Capital Management LP | 192,900 | 156,000 | 0.49% | ||
| 24 | GROUP ONE TRADING LLC | 155,433 | 126,000 | 0.39% | ||
| 25 | BlackRock Fund Advisors | 148,091 | 120,000 | 0.37% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 135,800 | 110,000 | 0.34% | Put | |
| 27 | DEUTSCHE BANK AG\ | 130,635 | 105,000 | 0.33% | ||
| 28 | GOLDMAN SACHS GROUP INC | 119,335 | 97,000 | 0.30% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 118,525 | 96,000 | 0.30% | ||
| 30 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 116,500 | 94,000 | 0.29% | ||
| 31 | Virtu KCG Holdings LLC | 101,660 | 82,000 | 0.26% | ||
| 32 | NORTHERN TRUST CORP | 96,160 | 78,000 | 0.24% | ||
| 33 | D. E. Shaw & Co., Inc. | 82,752 | 67,000 | 0.21% | ||
| 34 | Bank of New York Mellon Corp | 58,932 | 48,000 | 0.15% | ||
| 35 | FRANKLIN STREET ADVISORS INC /NC | 50,000 | 41,000 | 0.13% | ||
| 36 | COWEN INC. | 40,800 | 33,000 | 0.10% | Call | |
| 37 | Weiss Multi-Strategy Advisers LLC | 40,500 | 33,000 | 0.10% | ||
| 38 | ROYAL BANK OF CANADA | 31,185 | 26,000 | 0.08% | ||
| 39 | TWO SIGMA SECURITIES, LLC | 28,388 | 23,000 | 0.07% | ||
| 40 | STATE STREET CORP | 27,851 | 23,000 | 0.07% | ||
| 41 | Noven Financial Group, Inc. | 26,000 | 21,000 | 0.07% | ||
| 42 | JPMORGAN CHASE & CO | 23,047 | 19,000 | 0.06% | ||
| 43 | UBS Group AG | 16,900 | 14,000 | 0.04% | ||
| 44 | CITADEL ADVISORS LLC | 14,276 | 12,000 | 0.04% | ||
| 45 | BLACKROCK ADVISORS LLC | 14,059 | 11,000 | 0.03% | ||
| 46 | SIMPLEX TRADING, LLC | 14,788 | 11,000 | 0.03% | ||
| 47 | GUGGENHEIM CAPITAL LLC | 11,298 | 9,000 | 0.03% | ||
| 48 | Northeast Financial Consultants Inc | 11,000 | 9,000 | 0.03% | ||
| 49 | WELLS FARGO & COMPANY/MN | 10,829 | 9,000 | 0.03% | ||
| 50 | BlackRock Investment Management, LLC | 10,320 | 8,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
