| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,042,631 | 52,438,000 | 18.08% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 4,869,261 | 31,748,000 | 10.95% | ||
| 3 | Visium Asset Management, LP | 4,526,750 | 29,514,000 | 10.17% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,513,400 | 22,907,000 | 7.90% | ||
| 5 | FRANKLIN RESOURCES INC | 1,853,900 | 12,087,000 | 4.17% | ||
| 6 | PALISADE CAPITAL MANAGEMENT, LP | 1,607,815 | 10,483,000 | 3.61% | ||
| 7 | VANGUARD GROUP INC | 1,324,475 | 8,636,000 | 2.98% | ||
| 8 | ORBIMED ADVISORS LLC | 1,200,000 | 7,824,000 | 2.70% | ||
| 9 | BlackRock Fund Advisors | 1,199,361 | 7,820,000 | 2.70% | ||
| 10 | EAGLE ASSET MANAGEMENT INC | 1,165,542 | 7,599,000 | 2.62% | ||
| 11 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 905,100 | 5,901,000 | 2.03% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 697,800 | 4,550,000 | 1.57% | Call | |
| 13 | HealthCor Management, L.P. | 690,000 | 4,499,000 | 1.55% | ||
| 14 | STIFEL FINANCIAL CORP | 671,070 | 4,375,000 | 1.51% | ||
| 15 | FARALLON CAPITAL MANAGEMENT LLC | 670,000 | 4,368,000 | 1.51% | ||
| 16 | AXA S.A. | 591,155 | 3,854,000 | 1.33% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 544,650 | 3,551,000 | 1.22% | ||
| 18 | DEERFIELD MANAGEMENT COMPANY, L.P. | 505,741 | 3,297,000 | 1.14% | ||
| 19 | UBS AG | 492,365 | 3,210,000 | 1.11% | ||
| 20 | STATE STREET CORP | 484,762 | 3,158,000 | 1.09% | ||
| 21 | Point72 Asset Management, L.P. | 468,500 | 3,055,000 | 1.05% | ||
| 22 | ALYDAR PARTNERS LLC | 455,565 | 2,970,000 | 1.02% | ||
| 23 | NORTHERN TRUST CORP | 441,753 | 2,880,000 | 0.99% | ||
| 24 | PRINCIPAL FINANCIAL GROUP INC | 344,900 | 2,249,000 | 0.78% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 344,685 | 2,247,000 | 0.77% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 327,800 | 2,137,000 | 0.74% | Put | |
| 27 | FEDERATED HERMES, INC. | 310,900 | 2,027,000 | 0.70% | ||
| 28 | Nicholas Investment Partners, LP | 308,624 | 2,012,000 | 0.69% | ||
| 29 | Bank of New York Mellon Corp | 260,130 | 1,696,000 | 0.58% | ||
| 30 | BLACKROCK ADVISORS LLC | 234,140 | 1,527,000 | 0.53% | ||
| 31 | D. E. Shaw & Co., Inc. | 224,265 | 1,462,000 | 0.50% | ||
| 32 | ROYAL BANK OF CANADA | 212,821 | 1,387,000 | 0.48% | ||
| 33 | SMITH ASSET MANAGEMENT GROUP LP | 203,838 | 1,329,000 | 0.46% | ||
| 34 | Rhenman & Partners Asset Management AB | 201,171 | 1,312,000 | 0.45% | ||
| 35 | EverPoint Asset Management, LLC | 200,000 | 1,304,000 | 0.45% | ||
| 36 | First Eagle Investment Management, LLC | 200,000 | 1,304,000 | 0.45% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 192,967 | 1,258,000 | 0.43% | ||
| 38 | J. Goldman & Co LP | 190,000 | 1,239,000 | 0.43% | Call | |
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 182,185 | 1,188,000 | 0.41% | ||
| 40 | AMERIPRISE FINANCIAL INC | 179,741 | 1,172,000 | 0.40% | ||
| 41 | DSC Advisors, L.P. | 175,000 | 1,141,000 | 0.39% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 167,962 | 1,095,000 | 0.38% | ||
| 43 | MANAGED ACCOUNT ADVISORS LLC | 164,529 | 1,073,000 | 0.37% | ||
| 44 | Healthcare Value Capital, LLC | 150,000 | 978,000 | 0.34% | Call | |
| 45 | BlackRock Investment Management, LLC | 142,588 | 930,000 | 0.32% | ||
| 46 | MUNDER CAPITAL MANAGEMENT | 124,391 | 811,000 | 0.28% | ||
| 47 | ESSEX INVESTMENT MANAGEMENT CO LLC | 116,556 | 760,000 | 0.26% | ||
| 48 | PUTNAM INVESTMENTS LLC | 114,732 | 748,000 | 0.26% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 109,731 | 716,000 | 0.25% | ||
| 50 | TD ASSET MANAGEMENT INC | 107,800 | 703,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
