| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 8,250,000 | 4,455,000 | 18.17% | ||
| 2 | NEA Management Company, LLC | 7,789,644 | 4,206,000 | 17.16% | ||
| 3 | Palo Alto Investors LP | 6,974,854 | 3,766,000 | 15.36% | ||
| 4 | BVF INC/IL | 4,813,294 | 2,599,000 | 10.60% | ||
| 5 | BAKER BROS. ADVISORS LP | 4,450,000 | 2,403,000 | 9.80% | ||
| 6 | FMR LLC | 4,116,017 | 2,223,000 | 9.07% | ||
| 7 | VANGUARD GROUP INC | 2,478,372 | 1,339,000 | 5.46% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,985,617 | 1,072,000 | 4.37% | ||
| 9 | Frontier Wealth Management LLC | 488,570 | 264,000 | 1.08% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 459,717 | 248,000 | 1.01% | ||
| 11 | DAFNA Capital Management LLC | 423,336 | 229,000 | 0.93% | ||
| 12 | FEDERATED HERMES, INC. | 400,000 | 216,000 | 0.88% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 339,887 | 183,000 | 0.75% | ||
| 14 | JACOBS LEVY EQUITY MANAGEMENT, INC | 320,734 | 173,000 | 0.71% | ||
| 15 | D. E. Shaw & Co., Inc. | 234,903 | 126,000 | 0.51% | ||
| 16 | FRANKLIN STREET ADVISORS INC /NC | 200,000 | 108,000 | 0.44% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 172,207 | 93,000 | 0.38% | ||
| 18 | Healthcare Value Capital, LLC | 150,000 | 81,000 | 0.33% | Call | |
| 19 | BlackRock Fund Advisors | 145,557 | 79,000 | 0.32% | ||
| 20 | DEUTSCHE BANK AG\ | 130,694 | 70,000 | 0.29% | ||
| 21 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 116,500 | 63,000 | 0.26% | ||
| 22 | GROUP ONE TRADING LLC | 97,913 | 53,000 | 0.22% | ||
| 23 | NORTHERN TRUST CORP | 96,160 | 52,000 | 0.21% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 90,600 | 49,000 | 0.20% | Put | |
| 25 | MORGAN STANLEY | 72,822 | 40,000 | 0.16% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 70,036 | 38,000 | 0.16% | ||
| 27 | Bank of New York Mellon Corp | 58,932 | 32,000 | 0.13% | ||
| 28 | GOLDMAN SACHS GROUP INC | 52,730 | 28,000 | 0.11% | ||
| 29 | JPMORGAN CHASE & CO | 45,112 | 24,000 | 0.10% | ||
| 30 | Virtu KCG Holdings LLC | 44,101 | 24,000 | 0.10% | ||
| 31 | Weiss Multi-Strategy Advisers LLC | 40,000 | 22,000 | 0.09% | ||
| 32 | Noven Financial Group, Inc. | 41,000 | 22,000 | 0.09% | ||
| 33 | CITADEL ADVISORS LLC | 27,782 | 15,000 | 0.06% | ||
| 34 | STATE STREET CORP | 27,851 | 15,000 | 0.06% | ||
| 35 | GUGGENHEIM CAPITAL LLC | 25,009 | 14,000 | 0.06% | ||
| 36 | TFS CAPITAL LLC | 25,570 | 14,000 | 0.06% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,800 | 13,000 | 0.05% | Call | |
| 38 | BLACKROCK ADVISORS LLC | 14,059 | 8,000 | 0.03% | ||
| 39 | ROYAL BANK OF CANADA | 12,134 | 7,000 | 0.03% | ||
| 40 | SIMPLEX TRADING, LLC | 12,564 | 6,000 | 0.02% | ||
| 41 | Northeast Financial Consultants Inc | 11,000 | 6,000 | 0.02% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 11,000 | 6,000 | 0.02% | ||
| 43 | BlackRock Investment Management, LLC | 11,505 | 6,000 | 0.02% | ||
| 44 | CHILTON CAPITAL MANAGEMENT LLC | 10,000 | 5,000 | 0.02% | ||
| 45 | CITIGROUP INC | 7,300 | 4,000 | 0.02% | Call | |
| 46 | WELLS FARGO & COMPANY/MN | 7,329 | 4,000 | 0.02% | ||
| 47 | Walleye Trading LLC | 4,850 | 3,000 | 0.01% | ||
| 48 | Tower Research Capital LLC (TRC) | 2,903 | 2,000 | 0.01% | ||
| 49 | UBS Group AG | 2,500 | 1,000 | 0.00% | ||
| 50 | Hanson & Doremus Investment Management | 1,000 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
