| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 8,250,000 | 7,404,000 | 18.08% | ||
| 2 | NEA Management Company, LLC | 7,789,644 | 7,011,000 | 17.12% | ||
| 3 | Palo Alto Investors LP | 6,974,854 | 6,260,000 | 15.28% | ||
| 4 | FMR LLC | 5,083,834 | 4,563,000 | 11.14% | ||
| 5 | BVF INC/IL | 4,777,381 | 4,288,000 | 10.47% | ||
| 6 | BAKER BROS. ADVISORS LP | 4,450,000 | 3,994,000 | 9.75% | ||
| 7 | VANGUARD GROUP INC | 2,142,511 | 1,923,000 | 4.70% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 2,067,122 | 1,855,000 | 4.53% | ||
| 9 | Frontier Wealth Management LLC | 527,870 | 474,000 | 1.16% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 459,717 | 413,000 | 1.01% | ||
| 11 | FEDERATED HERMES, INC. | 400,000 | 359,000 | 0.88% | ||
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 340,052 | 305,000 | 0.74% | ||
| 13 | D. E. Shaw & Co., Inc. | 236,443 | 212,000 | 0.52% | ||
| 14 | ASCEND CAPITAL, LLC | 208,900 | 186,000 | 0.45% | Call | |
| 15 | BlackRock Fund Advisors | 154,773 | 139,000 | 0.34% | ||
| 16 | Healthcare Value Capital, LLC | 150,000 | 135,000 | 0.33% | Call | |
| 17 | GROUP ONE TRADING LLC | 136,833 | 123,000 | 0.30% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 135,300 | 121,000 | 0.30% | Call | |
| 19 | DEUTSCHE BANK AG\ | 130,694 | 117,000 | 0.29% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 117,701 | 105,000 | 0.26% | ||
| 21 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 116,500 | 105,000 | 0.26% | ||
| 22 | FRANKLIN STREET ADVISORS INC /NC | 100,000 | 90,000 | 0.22% | ||
| 23 | NORTHERN TRUST CORP | 96,160 | 87,000 | 0.21% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 93,600 | 84,000 | 0.21% | Put | |
| 25 | MORGAN STANLEY | 75,792 | 68,000 | 0.17% | ||
| 26 | Bank of New York Mellon Corp | 64,185 | 58,000 | 0.14% | ||
| 27 | GOLDMAN SACHS GROUP INC | 63,982 | 57,000 | 0.14% | ||
| 28 | UBS Group AG | 49,814 | 45,000 | 0.11% | ||
| 29 | TFS CAPITAL LLC | 50,042 | 45,000 | 0.11% | ||
| 30 | Anson Funds Management LP | 45,000 | 40,000 | 0.10% | ||
| 31 | JPMORGAN CHASE & CO | 41,999 | 38,000 | 0.09% | ||
| 32 | Noven Financial Group, Inc. | 41,000 | 37,000 | 0.09% | ||
| 33 | Weiss Multi-Strategy Advisers LLC | 40,000 | 36,000 | 0.09% | ||
| 34 | STATE STREET CORP | 27,851 | 25,000 | 0.06% | ||
| 35 | ROYAL BANK OF CANADA | 22,385 | 20,000 | 0.05% | ||
| 36 | CITADEL ADVISORS LLC | 15,864 | 14,000 | 0.03% | ||
| 37 | BLACKROCK ADVISORS LLC | 14,059 | 13,000 | 0.03% | ||
| 38 | TWO SIGMA SECURITIES, LLC | 12,088 | 11,000 | 0.03% | ||
| 39 | Virtu KCG Holdings LLC | 11,864 | 11,000 | 0.03% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 11,000 | 10,000 | 0.02% | ||
| 41 | BlackRock Investment Management, LLC | 11,319 | 10,000 | 0.02% | ||
| 42 | GUGGENHEIM CAPITAL LLC | 11,298 | 10,000 | 0.02% | ||
| 43 | SIMPLEX TRADING, LLC | 11,664 | 10,000 | 0.02% | ||
| 44 | Northeast Financial Consultants Inc | 11,000 | 10,000 | 0.02% | ||
| 45 | CHILTON CAPITAL MANAGEMENT LLC | 10,000 | 9,000 | 0.02% | ||
| 46 | Tower Research Capital LLC (TRC) | 7,006 | 6,000 | 0.01% | ||
| 47 | WELLS FARGO & COMPANY/MN | 7,329 | 6,000 | 0.01% | ||
| 48 | CITIGROUP INC | 5,800 | 5,000 | 0.01% | Call | |
| 49 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 2,000 | 2,000 | 0.00% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,918 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
