| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 10,275,113 | 1,437,077,000 | 16.52% | ||
| 2 | FMR LLC | 7,698,186 | 1,076,669,000 | 12.37% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 5,147,685 | 719,955,000 | 8.27% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,814,735 | 673,389,000 | 7.74% | ||
| 5 | BlackRock Finance, Inc. | 3,605,247 | 504,230,000 | 5.80% | ||
| 6 | VANGUARD GROUP INC | 2,978,236 | 416,537,000 | 4.79% | ||
| 7 | INTERWEST VENTURE MANAGEMENT CO | 2,021,738 | 282,760,000 | 3.25% | ||
| 8 | FRANKLIN RESOURCES INC | 1,875,422 | 262,301,000 | 3.01% | ||
| 9 | STATE STREET CORP | 1,168,913 | 163,496,000 | 1.88% | ||
| 10 | ORACLE INVESTMENT MANAGEMENT INC | 1,052,579 | 147,214,000 | 1.69% | ||
| 11 | BB BIOTECH AG | 877,990 | 122,796,000 | 1.41% | ||
| 12 | JANUS HENDERSON GROUP PLC | 717,150 | 100,301,000 | 1.15% | ||
| 13 | Bank of New York Mellon Corp | 703,774 | 98,430,000 | 1.13% | ||
| 14 | AMERIPRISE FINANCIAL INC | 641,466 | 89,716,000 | 1.03% | ||
| 15 | PointState Capital LP | 614,695 | 85,971,000 | 0.99% | ||
| 16 | Rock Springs Capital Management LP | 490,500 | 68,601,000 | 0.79% | ||
| 17 | GOLDMAN SACHS GROUP INC | 461,932 | 64,606,000 | 0.74% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 455,500 | 63,706,000 | 0.73% | Put | |
| 19 | PICTET ASSET MANAGEMENT LTD | 399,105 | 59,590,000 | 0.68% | ||
| 20 | Avoro Capital Advisors LLC | 400,403 | 56,000,000 | 0.64% | ||
| 21 | DAVIDE LEONE & PARTNERS INVESTMENT Co LLP | 380,700 | 53,245,000 | 0.61% | Call | |
| 22 | LORD, ABBETT & CO. LLC | 373,906 | 52,294,000 | 0.60% | ||
| 23 | Sachem Head Capital Management LP | 373,136 | 52,187,000 | 0.60% | ||
| 24 | DEUTSCHE BANK AG\ | 362,431 | 50,687,000 | 0.58% | ||
| 25 | PERCEPTIVE ADVISORS LLC | 359,551 | 50,287,000 | 0.58% | SH | |
| 26 | EAGLE ASSET MANAGEMENT INC | 353,356 | 49,420,000 | 0.57% | ||
| 27 | ALLIANCEBERNSTEIN L.P. | 351,521 | 49,164,000 | 0.57% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 341,608 | 47,777,000 | 0.55% | ||
| 29 | BARCLAYS PLC | 337,100 | 47,147,000 | 0.54% | Call | |
| 30 | MILLENNIUM MANAGEMENT LLC | 323,268 | 45,212,000 | 0.52% | ||
| 31 | JENNISON ASSOCIATES LLC | 321,624 | 44,982,000 | 0.52% | ||
| 32 | AMUNDI ASSET MANAGEMENT US, INC. | 317,753 | 44,441,000 | 0.51% | ||
| 33 | NORGES BANK | 317,369 | 44,387,000 | 0.51% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 313,900 | 43,902,000 | 0.50% | Call | |
| 35 | FEDERATED HERMES, INC. | 308,003 | 43,077,000 | 0.50% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 299,292 | 41,841,000 | 0.48% | ||
| 37 | Alyeska Investment Group, L.P. | 296,685 | 41,494,000 | 0.48% | ||
| 38 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 289,949 | 40,552,267 | 0.47% | ||
| 39 | FRED ALGER MANAGEMENT, LLC | 288,000 | 40,280,000 | 0.46% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 281,395 | 39,356,000 | 0.45% | ||
| 41 | Twin Tree Management, LP | 237,200 | 33,175,000 | 0.38% | Call | |
| 42 | Artal Group S.A. | 235,000 | 32,867,000 | 0.38% | Call | |
| 43 | CITADEL ADVISORS LLC | 217,720 | 30,450,000 | 0.35% | ||
| 44 | MACQUARIE GROUP LTD | 215,881 | 30,193,000 | 0.35% | ||
| 45 | NORTHERN TRUST CORP | 207,112 | 28,967,000 | 0.33% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 192,025 | 26,857,000 | 0.31% | ||
| 47 | Invesco Ltd. | 190,794 | 26,685,000 | 0.31% | ||
| 48 | GOLDMAN SACHS GROUP INC | 173,400 | 24,252,000 | 0.28% | Put | |
| 49 | TEACHERS ADVISORS, LLC | 167,285 | 23,396,000 | 0.27% | ||
| 50 | Candriam S.C.A. | 162,060 | 22,667,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
