| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,674,395 | 141,721,000 | 19.62% | ||
| 2 | Capital Research Global Investors | 3,002,715 | 115,815,000 | 16.03% | ||
| 3 | Third Rock Ventures, LLC | 2,416,974 | 93,223,000 | 12.91% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,075,268 | 41,473,000 | 5.74% | ||
| 5 | BlackRock Fund Advisors | 759,913 | 29,310,000 | 4.06% | ||
| 6 | JENNISON ASSOCIATES LLC | 618,662 | 23,862,000 | 3.30% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 503,062 | 19,403,000 | 2.69% | ||
| 8 | Point72 Asset Management, L.P. | 491,400 | 18,953,000 | 2.62% | ||
| 9 | VANGUARD GROUP INC | 401,904 | 15,502,000 | 2.15% | ||
| 10 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 377,039 | 14,542,000 | 2.01% | ||
| 11 | QVT Financial LP | 366,600 | 14,140,000 | 1.96% | ||
| 12 | FRANKLIN RESOURCES INC | 338,532 | 13,057,000 | 1.81% | ||
| 13 | GOLDMAN SACHS GROUP INC | 317,044 | 12,228,000 | 1.69% | ||
| 14 | RS INVESTMENT MANAGEMENT CO LLC | 300,549 | 11,592,000 | 1.60% | ||
| 15 | PointState Capital LP | 275,000 | 10,607,000 | 1.47% | ||
| 16 | STATE STREET CORP | 250,626 | 9,668,000 | 1.34% | ||
| 17 | Artal Group S.A. | 250,000 | 9,643,000 | 1.33% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 207,071 | 7,987,000 | 1.11% | ||
| 19 | BAKER BROS. ADVISORS LP | 198,260 | 7,647,000 | 1.06% | ||
| 20 | ORACLE INVESTMENT MANAGEMENT INC | 178,937 | 6,901,600 | 0.96% | ||
| 21 | FRED ALGER MANAGEMENT, LLC | 172,778 | 6,664,000 | 0.92% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 141,464 | 5,456,000 | 0.76% | ||
| 23 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 132,000 | 5,091,000 | 0.70% | ||
| 24 | LORD, ABBETT & CO. LLC | 119,076 | 4,593,000 | 0.64% | ||
| 25 | DEUTSCHE BANK AG\ | 105,633 | 4,073,000 | 0.56% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 104,601 | 4,034,000 | 0.56% | ||
| 27 | NORTHERN TRUST CORP | 93,116 | 3,591,000 | 0.50% | ||
| 28 | COWEN INC. | 92,408 | 3,564,000 | 0.49% | ||
| 29 | DRIEHAUS CAPITAL MANAGEMENT LLC | 83,304 | 3,213,000 | 0.44% | ||
| 30 | EverPoint Asset Management, LLC | 80,000 | 3,086,000 | 0.43% | ||
| 31 | EVENTIDE ASSET MANAGEMENT, LLC | 76,900 | 2,966,000 | 0.41% | ||
| 32 | Bank of New York Mellon Corp | 76,768 | 2,961,000 | 0.41% | ||
| 33 | Weiss Multi-Strategy Advisers LLC | 70,000 | 2,700,000 | 0.37% | ||
| 34 | BLACKROCK ADVISORS LLC | 60,589 | 2,337,000 | 0.32% | ||
| 35 | BlackRock Investment Management, LLC | 58,044 | 2,239,000 | 0.31% | ||
| 36 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 54,800 | 2,114,000 | 0.29% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 54,582 | 2,105,000 | 0.29% | ||
| 38 | Tekla Capital Management LLC | 54,527 | 2,103,000 | 0.29% | ||
| 39 | GOLDMAN SACHS GROUP INC | 52,600 | 2,029,000 | 0.28% | Call | |
| 40 | MUFG Securities EMEA plc | 52,500 | 2,024,925 | 0.28% | ||
| 41 | PRINCIPAL FINANCIAL GROUP INC | 52,297 | 2,017,000 | 0.28% | ||
| 42 | CREDIT SUISSE AG/ | 51,996 | 2,006,000 | 0.28% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,600 | 1,990,000 | 0.28% | Put | |
| 44 | Cupps Capital Management, LLC | 51,495 | 1,986,000 | 0.27% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 50,342 | 1,942,000 | 0.27% | ||
| 46 | GREEN ARROW CAPITAL MANAGEMENT LLC | 50,000 | 1,929,000 | 0.27% | ||
| 47 | FIDUCIARY TRUST CO | 49,729 | 1,918,000 | 0.27% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,800 | 1,342,000 | 0.19% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 33,146 | 1,279,000 | 0.18% | ||
| 50 | Invesco Ltd. | 32,770 | 1,264,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
