| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,719,778 | 570,007,000 | 14.54% | ||
| 2 | Capital Research Global Investors | 3,989,375 | 481,797,000 | 12.29% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,921,268 | 232,032,000 | 5.92% | ||
| 4 | VANGUARD GROUP INC | 1,386,924 | 167,499,000 | 4.27% | ||
| 5 | Capital World Investors | 1,358,000 | 164,006,000 | 4.18% | ||
| 6 | BAILLIE GIFFORD & CO | 1,283,962 | 155,064,000 | 3.95% | ||
| 7 | BlackRock Fund Advisors | 1,096,674 | 132,445,000 | 3.38% | ||
| 8 | LORD, ABBETT & CO. LLC | 753,170 | 90,960,000 | 2.32% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 752,489 | 90,878,000 | 2.32% | ||
| 10 | OppenheimerFunds, Inc. | 705,340 | 85,184,000 | 2.17% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 689,435 | 83,263,000 | 2.12% | ||
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 631,309 | 76,243,000 | 1.94% | ||
| 13 | STATE STREET CORP | 594,657 | 71,819,000 | 1.83% | ||
| 14 | JENNISON ASSOCIATES LLC | 589,323 | 71,173,000 | 1.82% | ||
| 15 | ORBIMED ADVISORS LLC | 550,700 | 66,508,000 | 1.70% | ||
| 16 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 547,795 | 66,157,000 | 1.69% | ||
| 17 | FRANKLIN RESOURCES INC | 454,132 | 54,846,000 | 1.40% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 402,800 | 48,646,000 | 1.24% | ||
| 19 | WELLS FARGO & COMPANY/MN | 366,910 | 44,312,000 | 1.13% | ||
| 20 | Artal Group S.A. | 350,000 | 42,270,000 | 1.08% | ||
| 21 | Tourbillon Capital Partners, L.P. | 320,000 | 38,646,000 | 0.99% | ||
| 22 | NORTHERN TRUST CORP | 287,513 | 34,723,000 | 0.89% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 275,100 | 33,224,000 | 0.85% | Put | |
| 24 | COLUMBUS CIRCLE INVESTORS | 262,753 | 31,733,000 | 0.81% | ||
| 25 | GOLDMAN SACHS GROUP INC | 254,050 | 30,682,000 | 0.78% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 251,600 | 30,386,000 | 0.77% | Call | |
| 27 | RS INVESTMENT MANAGEMENT CO LLC | 250,164 | 30,212,000 | 0.77% | ||
| 28 | FRONTIER CAPITAL MANAGEMENT CO LLC | 250,065 | 30,200,000 | 0.77% | ||
| 29 | Invesco Ltd. | 240,829 | 29,086,000 | 0.74% | ||
| 30 | RA CAPITAL MANAGEMENT, L.P. | 200,379 | 24,200,000 | 0.62% | ||
| 31 | PFM Health Sciences, LP | 199,745 | 24,123,000 | 0.62% | ||
| 32 | CITADEL ADVISORS LLC | 192,286 | 23,223,000 | 0.59% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 192,090 | 23,198,000 | 0.59% | ||
| 34 | Duquesne Family Office LLC | 184,082 | 22,232,000 | 0.57% | ||
| 35 | AMERIPRISE FINANCIAL INC | 176,671 | 21,336,000 | 0.54% | ||
| 36 | Bank of New York Mellon Corp | 163,641 | 19,763,000 | 0.50% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 156,924 | 18,952,000 | 0.48% | ||
| 38 | BAKER BROS. ADVISORS LP | 146,581 | 17,703,000 | 0.45% | ||
| 39 | JPMORGAN CHASE & CO | 141,905 | 17,137,000 | 0.44% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 141,152 | 17,047,000 | 0.43% | ||
| 41 | NORGES BANK | 139,129 | 16,803,000 | 0.43% | ||
| 42 | PERCEPTIVE ADVISORS LLC | 135,000 | 16,304,000 | 0.42% | ||
| 43 | MILLENNIUM MANAGEMENT LLC | 130,000 | 15,700,000 | 0.40% | Put | |
| 44 | DEUTSCHE BANK AG\ | 129,055 | 15,583,000 | 0.40% | ||
| 45 | FRED ALGER MANAGEMENT, LLC | 125,686 | 15,179,000 | 0.39% | ||
| 46 | Mitsubishi UFJ Trust & Banking Corp | 123,500 | 14,915,000 | 0.38% | ||
| 47 | CADIAN CAPITAL MANAGEMENT, LP | 120,000 | 14,492,000 | 0.37% | ||
| 48 | QVT Financial LP | 117,844 | 14,232,000 | 0.36% | ||
| 49 | Nuveen Asset Management, LLC | 117,668 | 14,211,000 | 0.36% | ||
| 50 | TEACHERS ADVISORS, LLC | 107,734 | 13,011,000 | 0.33% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
