| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,285,269 | 153,755,000 | 17.69% | ||
| 2 | Capital Research Global Investors | 3,502,915 | 125,685,000 | 14.46% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,258,687 | 45,162,000 | 5.20% | ||
| 4 | Third Rock Ventures, LLC | 1,215,054 | 43,596,000 | 5.02% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,067,271 | 38,294,000 | 4.41% | ||
| 6 | BlackRock Fund Advisors | 866,616 | 31,094,000 | 3.58% | ||
| 7 | STATE STREET CORP | 742,590 | 26,644,000 | 3.07% | ||
| 8 | RA CAPITAL MANAGEMENT, L.P. | 728,812 | 26,150,000 | 3.01% | ||
| 9 | VANGUARD GROUP INC | 627,673 | 22,521,000 | 2.59% | ||
| 10 | JENNISON ASSOCIATES LLC | 619,328 | 22,221,000 | 2.56% | ||
| 11 | Point72 Asset Management, L.P. | 594,900 | 21,345,000 | 2.46% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 585,457 | 21,006,000 | 2.42% | ||
| 13 | FRANKLIN RESOURCES INC | 456,332 | 16,373,000 | 1.88% | ||
| 14 | EVENTIDE ASSET MANAGEMENT, LLC | 395,700 | 14,198,000 | 1.63% | ||
| 15 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 381,841 | 13,700,000 | 1.58% | ||
| 16 | QVT Financial LP | 366,600 | 13,154,000 | 1.51% | ||
| 17 | RS INVESTMENT MANAGEMENT CO LLC | 332,549 | 11,932,000 | 1.37% | ||
| 18 | EMERALD ADVISERS, LLC | 267,390 | 9,594,000 | 1.10% | ||
| 19 | GOLDMAN SACHS GROUP INC | 254,577 | 9,134,000 | 1.05% | ||
| 20 | Artal Group S.A. | 250,000 | 8,970,000 | 1.03% | ||
| 21 | NORTHERN TRUST CORP | 245,012 | 8,791,000 | 1.01% | ||
| 22 | EMERALD MUTUAL FUND ADVISERS TRUST | 239,151 | 8,581,000 | 0.99% | ||
| 23 | GOLDMAN SACHS GROUP INC | 231,500 | 8,306,000 | 0.96% | Call | |
| 24 | LORD, ABBETT & CO. LLC | 210,273 | 7,545,000 | 0.87% | ||
| 25 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 207,000 | 7,425,000 | 0.85% | ||
| 26 | Tekla Capital Management LLC | 172,927 | 6,205,000 | 0.71% | ||
| 27 | Weiss Multi-Strategy Advisers LLC | 169,924 | 6,097,000 | 0.70% | ||
| 28 | FRED ALGER MANAGEMENT, LLC | 154,172 | 5,532,000 | 0.64% | ||
| 29 | BAKER BROS. ADVISORS LP | 150,000 | 5,382,000 | 0.62% | ||
| 30 | DEUTSCHE BANK AG\ | 146,170 | 5,243,000 | 0.60% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 132,360 | 4,749,000 | 0.55% | ||
| 32 | PointState Capital LP | 130,000 | 4,664,000 | 0.54% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 120,759 | 4,333,000 | 0.50% | ||
| 34 | Tekla Capital Management LLC | 118,400 | 4,248,000 | 0.49% | Call | |
| 35 | Bank of New York Mellon Corp | 110,917 | 3,980,000 | 0.46% | ||
| 36 | HAMILTON LANE ADVISORS LLC | 110,228 | 3,955,000 | 0.46% | ||
| 37 | EverPoint Asset Management, LLC | 110,000 | 3,947,000 | 0.45% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 110,007 | 3,947,000 | 0.45% | ||
| 39 | MORGAN STANLEY | 103,700 | 3,720,000 | 0.43% | ||
| 40 | COWEN INC. | 92,408 | 3,316,000 | 0.38% | ||
| 41 | ASCEND CAPITAL, LLC | 90,000 | 3,229,000 | 0.37% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,100 | 3,161,000 | 0.36% | Put | |
| 43 | Alyeska Investment Group, L.P. | 87,651 | 3,145,000 | 0.36% | ||
| 44 | CREDIT SUISSE AG/ | 82,277 | 2,952,000 | 0.34% | ||
| 45 | DRIEHAUS CAPITAL MANAGEMENT LLC | 77,132 | 2,767,000 | 0.32% | ||
| 46 | CITADEL ADVISORS LLC | 76,535 | 2,746,000 | 0.32% | ||
| 47 | AMERIPRISE FINANCIAL INC | 67,785 | 2,431,000 | 0.28% | ||
| 48 | BlackRock Investment Management, LLC | 66,303 | 2,379,000 | 0.27% | ||
| 49 | Invesco Ltd. | 66,177 | 2,375,000 | 0.27% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,200 | 2,196,000 | 0.25% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
