| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,720,878 | 433,000,000 | 15.20% | ||
| 2 | Capital Research Global Investors | 3,889,315 | 361,356,000 | 12.69% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,516,944 | 139,134,000 | 4.89% | ||
| 4 | Capital World Investors | 1,358,000 | 126,172,000 | 4.43% | ||
| 5 | Third Rock Ventures, LLC | 1,215,054 | 111,445,000 | 3.91% | ||
| 6 | BlackRock Fund Advisors | 948,851 | 87,029,000 | 3.06% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 850,932 | 78,047,000 | 2.74% | ||
| 8 | VANGUARD GROUP INC | 768,517 | 70,489,000 | 2.48% | ||
| 9 | OppenheimerFunds, Inc. | 752,560 | 69,025,000 | 2.42% | ||
| 10 | JENNISON ASSOCIATES LLC | 592,002 | 54,298,000 | 1.91% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 546,245 | 50,102,000 | 1.76% | ||
| 12 | STATE STREET CORP | 544,555 | 49,947,000 | 1.75% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 539,101 | 49,446,000 | 1.74% | ||
| 14 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 526,069 | 48,250,000 | 1.69% | ||
| 15 | RA CAPITAL MANAGEMENT, L.P. | 506,122 | 46,422,000 | 1.63% | ||
| 16 | FRONTIER CAPITAL MANAGEMENT CO LLC | 477,443 | 43,791,000 | 1.54% | ||
| 17 | LORD, ABBETT & CO. LLC | 449,236 | 41,204,000 | 1.45% | ||
| 18 | FRANKLIN RESOURCES INC | 428,832 | 39,332,000 | 1.38% | ||
| 19 | Tourbillon Capital Partners, L.P. | 420,500 | 38,568,000 | 1.35% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 390,000 | 35,771,000 | 1.26% | ||
| 21 | PFM Health Sciences, LP | 375,245 | 34,417,000 | 1.21% | ||
| 22 | WELLS FARGO & COMPANY/MN | 373,118 | 34,224,000 | 1.20% | ||
| 23 | GOLDMAN SACHS GROUP INC | 368,452 | 33,795,000 | 1.19% | ||
| 24 | Duquesne Family Office LLC | 355,400 | 32,597,000 | 1.14% | ||
| 25 | RS INVESTMENT MANAGEMENT CO LLC | 338,829 | 31,077,000 | 1.09% | ||
| 26 | Artal Group S.A. | 275,000 | 25,223,000 | 0.89% | ||
| 27 | AMERIPRISE FINANCIAL INC | 249,763 | 22,908,000 | 0.80% | ||
| 28 | NORTHERN TRUST CORP | 237,886 | 21,819,000 | 0.77% | ||
| 29 | PERCEPTIVE ADVISORS LLC | 225,000 | 20,637,000 | 0.72% | ||
| 30 | EMERALD ADVISERS, LLC | 219,046 | 20,091,000 | 0.71% | ||
| 31 | Invesco Ltd. | 215,429 | 19,759,000 | 0.69% | ||
| 32 | CITADEL ADVISORS LLC | 190,301 | 17,455,000 | 0.61% | ||
| 33 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 188,600 | 17,298,000 | 0.61% | ||
| 34 | FRED ALGER MANAGEMENT, LLC | 183,914 | 16,869,000 | 0.59% | ||
| 35 | Independence Capital Asset Partners, LLC | 180,045 | 16,514,000 | 0.58% | ||
| 36 | EMERALD MUTUAL FUND ADVISERS TRUST | 174,070 | 15,966,000 | 0.56% | ||
| 37 | QVT Financial LP | 162,800 | 14,932,000 | 0.52% | ||
| 38 | COLUMBUS CIRCLE INVESTORS | 150,408 | 13,795,000 | 0.48% | ||
| 39 | BAKER BROS. ADVISORS LP | 150,000 | 13,758,000 | 0.48% | ||
| 40 | Lamond Capital Partners LLC | 147,380 | 13,518,000 | 0.47% | ||
| 41 | DEUTSCHE BANK AG\ | 145,641 | 13,357,000 | 0.47% | ||
| 42 | JPMORGAN CHASE & CO | 136,072 | 12,480,000 | 0.44% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 134,200 | 12,309,000 | 0.43% | Call | |
| 44 | BNP Paribas Asset Management Holding S.A. | 133,966 | 12,287,000 | 0.43% | ||
| 45 | RENAISSANCE TECHNOLOGIES LLC | 130,900 | 12,006,000 | 0.42% | ||
| 46 | EverPoint Asset Management, LLC | 130,000 | 11,924,000 | 0.42% | ||
| 47 | Bank of New York Mellon Corp | 127,976 | 11,737,000 | 0.41% | ||
| 48 | Nuveen Asset Management, LLC | 127,359 | 11,681,000 | 0.41% | ||
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 119,495 | 10,960,000 | 0.38% | ||
| 50 | GEODE CAPITAL MANAGEMENT, LLC | 118,669 | 10,884,000 | 0.38% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
