| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,624,383 | 82,419,000 | 20.84% | ||
| 2 | Capital Research Global Investors | 2,960,748 | 67,327,000 | 17.03% | ||
| 3 | Third Rock Ventures, LLC | 2,416,974 | 54,962,000 | 13.90% | ||
| 4 | WADDELL & REED FINANCIAL INC | 1,099,300 | 24,998,000 | 6.32% | ||
| 5 | JENNISON ASSOCIATES LLC | 730,502 | 16,612,000 | 4.20% | ||
| 6 | BlackRock Fund Advisors | 483,547 | 10,996,000 | 2.78% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 467,418 | 10,629,000 | 2.69% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 414,474 | 9,425,000 | 2.38% | ||
| 9 | RS INVESTMENT MANAGEMENT CO LLC | 359,500 | 8,175,000 | 2.07% | ||
| 10 | FRANKLIN RESOURCES INC | 338,532 | 7,698,000 | 1.95% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 291,986 | 6,640,000 | 1.68% | ||
| 12 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 291,747 | 6,634,000 | 1.68% | ||
| 13 | PFM Health Sciences, LP | 291,031 | 6,618,000 | 1.67% | ||
| 14 | ORBIMED ADVISORS LLC | 289,000 | 6,572,000 | 1.66% | ||
| 15 | FRED ALGER MANAGEMENT, LLC | 273,359 | 6,216,000 | 1.57% | ||
| 16 | VANGUARD GROUP INC | 222,779 | 5,066,000 | 1.28% | ||
| 17 | BAKER BROS. ADVISORS LP | 198,260 | 4,508,000 | 1.14% | ||
| 18 | QVT Financial LP | 197,100 | 4,482,000 | 1.13% | ||
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 178,585 | 4,061,000 | 1.03% | ||
| 20 | BLACKROCK ADVISORS LLC | 172,947 | 3,933,000 | 0.99% | ||
| 21 | Artal Group S.A. | 150,000 | 3,411,000 | 0.86% | ||
| 22 | DRIEHAUS CAPITAL MANAGEMENT LLC | 143,414 | 3,261,000 | 0.82% | ||
| 23 | SAC Capital Advisors LP | 124,600 | 2,833,000 | 0.72% | ||
| 24 | DEUTSCHE BANK AG\ | 110,023 | 2,500,000 | 0.63% | ||
| 25 | COWEN INC. | 104,226 | 2,370,000 | 0.60% | ||
| 26 | SABBY MANAGEMENT, LLC | 101,786 | 2,315,000 | 0.59% | ||
| 27 | STATE STREET CORP | 90,291 | 2,054,000 | 0.52% | ||
| 28 | NORTHERN TRUST CORP | 90,128 | 2,049,000 | 0.52% | ||
| 29 | BlackRock Institutional Trust Company, N.A. | 84,405 | 1,919,000 | 0.49% | ||
| 30 | Tekla Capital Management LLC | 73,955 | 1,682,000 | 0.43% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 72,432 | 1,647,000 | 0.42% | ||
| 32 | EVENTIDE ASSET MANAGEMENT, LLC | 65,000 | 1,478,000 | 0.37% | ||
| 33 | ASCEND CAPITAL, LLC | 60,055 | 1,367,000 | 0.35% | ||
| 34 | GREEN ARROW CAPITAL MANAGEMENT LLC | 60,000 | 1,364,000 | 0.34% | ||
| 35 | CREDIT SUISSE AG/ | 57,539 | 1,309,000 | 0.33% | ||
| 36 | SPHERA FUNDS MANAGEMENT LTD. | 57,435 | 1,306,000 | 0.33% | ||
| 37 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 54,800 | 1,246,000 | 0.32% | ||
| 38 | PRINCIPAL FINANCIAL GROUP INC | 51,400 | 1,169,000 | 0.30% | ||
| 39 | FIDUCIARY TRUST CO | 50,479 | 1,148,000 | 0.29% | ||
| 40 | SIGMA CAPITAL MANAGEMENT LLC | 50,000 | 1,137,000 | 0.29% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 45,930 | 1,044,000 | 0.26% | ||
| 42 | BlackRock Group LTD | 36,600 | 832,000 | 0.21% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 32,108 | 730,000 | 0.18% | ||
| 44 | Bank of New York Mellon Corp | 30,710 | 698,000 | 0.18% | ||
| 45 | ProShare Advisors LLC | 25,114 | 571,000 | 0.14% | ||
| 46 | MORGAN STANLEY | 23,214 | 528,000 | 0.13% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 21,959 | 500,000 | 0.13% | ||
| 48 | PERCEPTIVE ADVISORS LLC | 20,000 | 455,000 | 0.12% | ||
| 49 | BlackRock Investment Management, LLC | 19,855 | 452,000 | 0.11% | ||
| 50 | Jasper Ridge Partners, L.P. | 18,800 | 428,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
