| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,541,457 | 239,889,000 | 12.33% | ||
| 2 | BAILLIE GIFFORD & CO | 5,054,175 | 218,795,000 | 11.24% | ||
| 3 | Capital Research Global Investors | 4,523,635 | 195,828,000 | 10.06% | ||
| 4 | VANGUARD GROUP INC | 2,680,871 | 116,055,000 | 5.96% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,444,381 | 105,817,000 | 5.44% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 2,075,954 | 89,869,000 | 4.62% | ||
| 7 | STATE STREET CORP | 1,699,977 | 73,592,000 | 3.78% | ||
| 8 | BlackRock Fund Advisors | 1,386,229 | 60,010,000 | 3.08% | ||
| 9 | OppenheimerFunds, Inc. | 1,352,334 | 58,543,000 | 3.01% | ||
| 10 | ORBIMED ADVISORS LLC | 1,185,800 | 51,333,000 | 2.64% | ||
| 11 | FRANKLIN RESOURCES INC | 1,161,832 | 50,296,000 | 2.58% | ||
| 12 | Capital World Investors | 937,000 | 40,563,000 | 2.08% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 902,966 | 39,089,000 | 2.01% | ||
| 14 | JENNISON ASSOCIATES LLC | 878,061 | 38,011,000 | 1.95% | ||
| 15 | RTW INVESTMENTS, LP | 612,025 | 26,495,000 | 1.36% | ||
| 16 | RS INVESTMENT MANAGEMENT CO LLC | 575,093 | 24,896,000 | 1.28% | ||
| 17 | ArrowMark Colorado Holdings LLC | 560,164 | 24,249,000 | 1.25% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 539,500 | 23,355,000 | 1.20% | ||
| 19 | GREAT POINT PARTNERS LLC | 500,000 | 21,645,000 | 1.11% | ||
| 20 | Artal Group S.A. | 450,000 | 19,481,000 | 1.00% | ||
| 21 | WELLS FARGO & COMPANY/MN | 440,830 | 19,084,000 | 0.98% | ||
| 22 | DEUTSCHE BANK AG\ | 439,780 | 19,035,000 | 0.98% | ||
| 23 | NORTHERN TRUST CORP | 404,141 | 17,495,000 | 0.90% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 360,000 | 15,584,000 | 0.80% | Put | |
| 25 | DEERFIELD MANAGEMENT COMPANY, L.P. | 338,085 | 14,636,000 | 0.75% | ||
| 26 | TIVERTON ASSET MANAGEMENT LLC | 486,223 | 12,875,000 | 0.66% | ||
| 27 | BAKER BROS. ADVISORS LP | 293,943 | 12,725,000 | 0.65% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 268,368 | 11,617,000 | 0.60% | ||
| 29 | NORGES BANK | 240,604 | 10,416,000 | 0.54% | ||
| 30 | Invesco Ltd. | 228,344 | 9,884,000 | 0.51% | ||
| 31 | BALYASNY ASSET MANAGEMENT L.P. | 225,167 | 9,747,000 | 0.50% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 218,149 | 9,444,000 | 0.49% | ||
| 33 | COLUMBUS CIRCLE INVESTORS | 201,150 | 8,708,000 | 0.45% | ||
| 34 | EMERALD ADVISERS, LLC | 194,144 | 8,404,000 | 0.43% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 176,200 | 7,628,000 | 0.39% | Call | |
| 36 | EverPoint Asset Management, LLC | 175,000 | 7,576,000 | 0.39% | ||
| 37 | Ghost Tree Capital, LLC | 170,000 | 7,359,000 | 0.38% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 168,000 | 7,273,000 | 0.37% | ||
| 39 | Bank of New York Mellon Corp | 167,217 | 7,239,000 | 0.37% | ||
| 40 | AXA S.A. | 163,557 | 7,080,000 | 0.36% | ||
| 41 | Mitsubishi UFJ Trust & Banking Corp | 159,560 | 6,907,000 | 0.35% | ||
| 42 | GOLDMAN SACHS GROUP INC | 155,086 | 6,714,000 | 0.35% | ||
| 43 | EMERALD MUTUAL FUND ADVISERS TRUST | 153,610 | 6,650,000 | 0.34% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 151,224 | 6,546,000 | 0.34% | ||
| 45 | BlackRock Investment Management, LLC | 146,840 | 6,357,000 | 0.33% | ||
| 46 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 145,991 | 6,320,000 | 0.32% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 145,569 | 6,302,000 | 0.32% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 130,101 | 5,632,000 | 0.29% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 129,958 | 5,626,000 | 0.29% | ||
| 50 | CASDIN CAPITAL, LLC | 122,500 | 5,303,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
