| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,539,145 | 235,413,000 | 13.36% | ||
| 2 | BAILLIE GIFFORD & CO | 4,977,637 | 211,549,000 | 12.01% | ||
| 3 | Capital Research Global Investors | 4,519,722 | 192,088,000 | 10.90% | ||
| 4 | VANGUARD GROUP INC | 2,347,475 | 99,767,000 | 5.66% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,160,663 | 91,828,000 | 5.21% | ||
| 6 | Capital World Investors | 1,340,000 | 56,950,000 | 3.23% | ||
| 7 | OppenheimerFunds, Inc. | 1,311,084 | 55,721,000 | 3.16% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 1,202,247 | 51,095,000 | 2.90% | ||
| 9 | STATE STREET CORP | 1,201,936 | 51,088,000 | 2.90% | ||
| 10 | FRANKLIN RESOURCES INC | 965,561 | 41,036,000 | 2.33% | ||
| 11 | ORBIMED ADVISORS LLC | 945,500 | 40,184,000 | 2.28% | ||
| 12 | JENNISON ASSOCIATES LLC | 876,870 | 37,267,000 | 2.12% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 870,780 | 37,008,000 | 2.10% | ||
| 14 | BlackRock Fund Advisors | 770,134 | 32,731,000 | 1.86% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 539,500 | 22,929,000 | 1.30% | ||
| 16 | RS INVESTMENT MANAGEMENT CO LLC | 527,754 | 22,430,000 | 1.27% | ||
| 17 | ArrowMark Colorado Holdings LLC | 500,253 | 21,261,000 | 1.21% | ||
| 18 | Artal Group S.A. | 500,000 | 21,250,000 | 1.21% | ||
| 19 | WELLS FARGO & COMPANY/MN | 450,284 | 19,137,000 | 1.09% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 428,200 | 18,199,000 | 1.03% | Put | |
| 21 | GOLDMAN SACHS GROUP INC | 406,360 | 17,270,000 | 0.98% | ||
| 22 | GREAT POINT PARTNERS LLC | 393,135 | 16,708,000 | 0.95% | ||
| 23 | DEUTSCHE BANK AG\ | 369,195 | 15,688,000 | 0.89% | ||
| 24 | BAKER BROS. ADVISORS LP | 352,943 | 15,000,000 | 0.85% | ||
| 25 | COLUMBUS CIRCLE INVESTORS | 340,918 | 14,489,000 | 0.82% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 339,424 | 14,426,000 | 0.82% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 281,954 | 11,983,000 | 0.68% | ||
| 28 | EMERALD ADVISERS, LLC | 260,879 | 11,087,000 | 0.63% | ||
| 29 | NORGES BANK | 241,230 | 10,252,000 | 0.58% | ||
| 30 | Invesco Ltd. | 232,721 | 9,891,000 | 0.56% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 232,398 | 9,876,000 | 0.56% | ||
| 32 | RTW INVESTMENTS, LP | 226,371 | 9,621,000 | 0.55% | ||
| 33 | BALYASNY ASSET MANAGEMENT L.P. | 215,660 | 9,166,000 | 0.52% | ||
| 34 | EMERALD MUTUAL FUND ADVISERS TRUST | 212,085 | 9,014,000 | 0.51% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 196,615 | 8,356,000 | 0.47% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 174,009 | 7,395,000 | 0.42% | ||
| 37 | Mitsubishi UFJ Trust & Banking Corp | 163,860 | 6,964,000 | 0.40% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 157,770 | 6,705,000 | 0.38% | ||
| 39 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 157,666 | 6,701,000 | 0.38% | ||
| 40 | Bank of New York Mellon Corp | 154,155 | 6,552,000 | 0.37% | ||
| 41 | AXA S.A. | 148,851 | 6,326,000 | 0.36% | ||
| 42 | NORTHERN TRUST CORP | 148,352 | 6,305,000 | 0.36% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 136,000 | 5,780,000 | 0.33% | Call | |
| 44 | CASDIN CAPITAL, LLC | 120,000 | 5,100,000 | 0.29% | ||
| 45 | GILDER GAGNON HOWE & CO LLC | 110,947 | 4,715,000 | 0.27% | ||
| 46 | AMERIPRISE FINANCIAL INC | 110,489 | 4,695,000 | 0.27% | ||
| 47 | CREDIT SUISSE AG/ | 106,043 | 4,507,000 | 0.26% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 101,521 | 4,315,000 | 0.24% | ||
| 49 | Artisan Partners Limited Partnership | 94,891 | 4,033,000 | 0.23% | ||
| 50 | TIVERTON ASSET MANAGEMENT LLC | 93,115 | 3,957,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
