| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 28,749,089 | 590,506,000 | 45.20% | ||
| 2 | FMR LLC | 6,762,100 | 138,894,000 | 10.63% | ||
| 3 | Capital Research Global Investors | 4,087,000 | 83,947,000 | 6.43% | ||
| 4 | FIRST MANHATTAN CO. LLC. | 3,784,730 | 77,738,000 | 5.95% | ||
| 5 | VANGUARD GROUP INC | 1,667,214 | 34,245,000 | 2.62% | ||
| 6 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,118,600 | 22,976,000 | 1.76% | Put | |
| 7 | Gotham Asset Management, LLC | 1,105,731 | 22,712,000 | 1.74% | ||
| 8 | Burgundy Asset Management Ltd. | 1,053,756 | 21,644,000 | 1.66% | ||
| 9 | SAC Capital Advisors LP | 1,043,700 | 21,438,000 | 1.64% | Put | |
| 10 | BlackRock Institutional Trust Company, N.A. | 703,588 | 14,452,000 | 1.11% | ||
| 11 | GOLDMAN SACHS GROUP INC | 649,351 | 13,338,000 | 1.02% | ||
| 12 | NORGES BANK | 589,925 | 12,117,000 | 0.93% | ||
| 13 | GOLDMAN SACHS GROUP INC | 556,200 | 11,424,000 | 0.87% | Put | |
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 540,900 | 11,110,000 | 0.85% | Call | |
| 15 | GOLDMAN SACHS GROUP INC | 408,500 | 8,391,000 | 0.64% | Call | |
| 16 | BlueCrest Capital Management LLP | 382,093 | 7,848,000 | 0.60% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 380,100 | 7,807,000 | 0.60% | Put | |
| 18 | STATE STREET CORP | 370,619 | 7,613,000 | 0.58% | ||
| 19 | MORGAN STANLEY | 357,005 | 7,332,000 | 0.56% | ||
| 20 | Spot Trading L.L.C | 338,400 | 6,951,000 | 0.53% | Put | |
| 21 | CHUBB CORP | 328,200 | 6,742,000 | 0.52% | ||
| 22 | CREDIT SUISSE AG/ | 316,307 | 6,496,000 | 0.50% | ||
| 23 | Pine River Capital Management L.P. | 290,698 | 5,971,000 | 0.46% | ||
| 24 | AUXIER ASSET MANAGEMENT LLC | 217,398 | 4,465,000 | 0.34% | ||
| 25 | GLG LLC | 210,575 | 4,325,000 | 0.33% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 208,932 | 4,292,000 | 0.33% | ||
| 27 | FIRST TRUST ADVISORS LP | 203,621 | 4,182,000 | 0.32% | ||
| 28 | CREDIT SUISSE AG/ | 200,000 | 4,108,000 | 0.31% | Put | |
| 29 | BlackRock Fund Advisors | 196,067 | 4,027,000 | 0.31% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 190,967 | 3,922,000 | 0.30% | ||
| 31 | PEAK6 Group LLC | 189,800 | 3,898,000 | 0.30% | Put | |
| 32 | Bank of New York Mellon Corp | 185,744 | 3,814,000 | 0.29% | ||
| 33 | PNC FINANCIAL SERVICES GROUP, INC. | 182,056 | 3,738,000 | 0.29% | ||
| 34 | A.R.T. Advisors, LLC | 166,780 | 3,425,000 | 0.26% | ||
| 35 | WHITEBOX ADVISORS LLC | 163,267 | 3,354,000 | 0.26% | ||
| 36 | Spot Trading L.L.C | 154,100 | 3,165,000 | 0.24% | Call | |
| 37 | Graham Capital Management, L.P. | 150,000 | 3,081,000 | 0.24% | Put | |
| 38 | D. E. Shaw & Co., Inc. | 145,000 | 2,978,000 | 0.23% | Put | |
| 39 | CONTINENTAL ADVISORS LLC | 140,900 | 2,894,000 | 0.22% | Call | |
| 40 | BANK OF AMERICA CORP /DE/ | 134,100 | 2,754,000 | 0.21% | Put | |
| 41 | Sculptor Capital LP | 132,900 | 2,730,000 | 0.21% | Put | |
| 42 | Roumell Asset Management, LLC | 44,040 | 2,725,000 | 0.21% | ||
| 43 | BOLTON LP | 129,300 | 2,656,000 | 0.20% | ||
| 44 | BESSEMER GROUP INC | 125,000 | 2,568,000 | 0.20% | ||
| 45 | GEODE CAPITAL MANAGEMENT, LLC | 124,621 | 2,559,000 | 0.20% | ||
| 46 | Jefferies Group LLC | 123,800 | 2,543,000 | 0.19% | Put | |
| 47 | DEUTSCHE BANK AG\ | 121,664 | 2,498,000 | 0.19% | ||
| 48 | NORTHERN TRUST CORP | 120,892 | 2,484,000 | 0.19% | ||
| 49 | Diversified Investment Strategies, LLC | 114,650 | 2,355,000 | 0.18% | ||
| 50 | SCOUT INVESTMENTS, INC. | 112,175 | 2,304,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
