| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 29,443,300 | 342,426,000 | 47.44% | ||
| 2 | FMR LLC | 9,569,152 | 111,289,000 | 15.42% | ||
| 3 | VANGUARD GROUP INC | 2,214,781 | 25,758,000 | 3.57% | ||
| 4 | State of New Jersey Common Pension Fund D | 1,550,000 | 18,027,000 | 2.50% | ||
| 5 | Invesco Ltd. | 1,089,469 | 12,671,000 | 1.76% | ||
| 6 | Hound Partners, LLC | 800,079 | 9,305,000 | 1.29% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 800,000 | 9,304,000 | 1.29% | ||
| 8 | COATUE MANAGEMENT LLC | 776,653 | 9,032,000 | 1.25% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 760,050 | 8,839,000 | 1.22% | ||
| 10 | BlackRock Fund Advisors | 657,257 | 7,644,000 | 1.06% | ||
| 11 | CITADEL ADVISORS LLC | 642,888 | 7,477,000 | 1.04% | ||
| 12 | HUSSMAN STRATEGIC ADVISORS, INC. | 600,000 | 6,978,000 | 0.97% | ||
| 13 | 12 West Capital Management LP | 598,388 | 6,959,000 | 0.96% | ||
| 14 | MORGAN STANLEY | 583,776 | 6,790,000 | 0.94% | ||
| 15 | CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 578,926 | 6,733,000 | 0.93% | ||
| 16 | Firefly Value Partners, LP | 537,000 | 6,245,000 | 0.87% | Put | |
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 477,100 | 5,549,000 | 0.77% | Put | |
| 18 | STATE STREET CORP | 460,587 | 5,358,000 | 0.74% | ||
| 19 | DEUTSCHE BANK AG\ | 401,917 | 4,673,000 | 0.65% | ||
| 20 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 398,376 | 4,634,000 | 0.64% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 397,200 | 4,619,000 | 0.64% | Call | |
| 22 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 347,067 | 4,036,000 | 0.56% | ||
| 23 | BANK OF MONTREAL /CAN/ | 344,924 | 4,011,000 | 0.56% | ||
| 24 | NORTHERN TRUST CORP | 323,894 | 3,767,000 | 0.52% | ||
| 25 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 289,471 | 3,367,000 | 0.47% | ||
| 26 | CITIGROUP INC | 283,243 | 3,294,000 | 0.46% | ||
| 27 | Ninety One UK Ltd | 255,993 | 2,977,000 | 0.41% | ||
| 28 | D. E. Shaw & Co., Inc. | 253,917 | 2,953,000 | 0.41% | ||
| 29 | Permit Capital, LLC | 251,150 | 2,921,000 | 0.40% | ||
| 30 | CITIGROUP INC | 248,800 | 2,894,000 | 0.40% | Put | |
| 31 | BARCLAYS PLC | 234,367 | 2,726,000 | 0.38% | ||
| 32 | GOLDMAN SACHS GROUP INC | 228,400 | 2,656,000 | 0.37% | Call | |
| 33 | KENNEDY CAPITAL MANAGEMENT LLC | 225,457 | 2,622,000 | 0.36% | ||
| 34 | Allianz Asset Management GmbH | 210,936 | 2,454,000 | 0.34% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 181,621 | 2,111,000 | 0.29% | ||
| 36 | Spot Trading L.L.C | 177,500 | 2,064,000 | 0.29% | Call | |
| 37 | GOLDMAN SACHS GROUP INC | 160,622 | 1,868,000 | 0.26% | ||
| 38 | A.R.T. Advisors, LLC | 147,447 | 1,714,000 | 0.24% | ||
| 39 | Bank of New York Mellon Corp | 143,968 | 1,674,000 | 0.23% | ||
| 40 | WOLVERINE ASSET MANAGEMENT LLC | 138,600 | 1,611,000 | 0.22% | Put | |
| 41 | MILLENNIUM MANAGEMENT LLC | 133,523 | 1,553,000 | 0.22% | ||
| 42 | Anandar Capital Management LP | 120,000 | 1,396,000 | 0.19% | Put | |
| 43 | DIMENSIONAL FUND ADVISORS LP | 110,919 | 1,290,000 | 0.18% | ||
| 44 | Hutchin Hill Capital, LP | 110,300 | 1,283,000 | 0.18% | ||
| 45 | SYMMETRY PEAK MANAGEMENT LLC | 104,300 | 1,213,000 | 0.17% | Call | |
| 46 | BlackRock Investment Management, LLC | 103,549 | 1,204,000 | 0.17% | ||
| 47 | Walleye Trading LLC | 101,300 | 1,180,000 | 0.16% | Put | |
| 48 | UBS Group AG | 100,205 | 1,166,000 | 0.16% | ||
| 49 | SMITH ASSET MANAGEMENT GROUP LP | 89,530 | 1,041,000 | 0.14% | ||
| 50 | GOLDMAN SACHS GROUP INC | 87,700 | 1,020,000 | 0.14% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
