| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 28,749,089 | 579,869,000 | 43.76% | ||
| 2 | FMR LLC | 5,981,800 | 120,653,000 | 9.10% | ||
| 3 | Capital Research Global Investors | 4,087,000 | 82,435,000 | 6.22% | ||
| 4 | FIRST MANHATTAN CO. LLC. | 3,521,933 | 71,037,000 | 5.36% | ||
| 5 | NORTH TIDE CAPITAL, LLC | 2,000,000 | 40,340,000 | 3.04% | ||
| 6 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,978,200 | 39,900,000 | 3.01% | Put | |
| 7 | VANGUARD GROUP INC | 1,625,781 | 32,791,000 | 2.47% | ||
| 8 | Gotham Asset Management, LLC | 992,675 | 20,022,000 | 1.51% | ||
| 9 | Point72 Asset Management, L.P. | 964,300 | 19,450,000 | 1.47% | Put | |
| 10 | Camber Capital Management LP | 850,000 | 17,144,000 | 1.29% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 706,659 | 14,253,000 | 1.08% | ||
| 12 | BlackRock Fund Advisors | 637,458 | 12,858,000 | 0.97% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 565,500 | 11,407,000 | 0.86% | Call | |
| 14 | STATE STREET CORP | 485,828 | 9,797,000 | 0.74% | ||
| 15 | NORGES BANK | 420,597 | 8,484,000 | 0.64% | ||
| 16 | Spot Trading L.L.C | 413,400 | 8,338,000 | 0.63% | Put | |
| 17 | GOLDMAN SACHS GROUP INC | 402,639 | 8,121,000 | 0.61% | ||
| 18 | Ninety One UK Ltd | 362,507 | 7,312,000 | 0.55% | ||
| 19 | Eos Management, L.P. | 35,900 | 7,241,000 | 0.55% | Put | |
| 20 | D. E. Shaw & Co., Inc. | 354,323 | 7,147,000 | 0.54% | ||
| 21 | CHUBB CORP | 328,200 | 6,620,000 | 0.50% | ||
| 22 | FIRST TRUST ADVISORS LP | 325,152 | 6,558,000 | 0.49% | ||
| 23 | CITADEL ADVISORS LLC | 315,636 | 6,367,000 | 0.48% | ||
| 24 | Passport Capital, LLC | 300,000 | 6,051,000 | 0.46% | Put | |
| 25 | GOLDMAN SACHS GROUP INC | 296,500 | 5,980,000 | 0.45% | Put | |
| 26 | Pine River Capital Management L.P. | 293,796 | 5,925,000 | 0.45% | ||
| 27 | WHITEBOX ADVISORS LLC | 235,767 | 4,755,000 | 0.36% | ||
| 28 | BlueCrest Capital Management LLP | 211,492 | 4,266,000 | 0.32% | ||
| 29 | GLG LLC | 210,575 | 4,247,000 | 0.32% | ||
| 30 | Spot Trading L.L.C | 203,800 | 4,111,000 | 0.31% | Call | |
| 31 | Bank of New York Mellon Corp | 201,406 | 4,061,000 | 0.31% | ||
| 32 | AUXIER ASSET MANAGEMENT LLC | 196,073 | 3,955,000 | 0.30% | ||
| 33 | GOLDMAN SACHS GROUP INC | 194,800 | 3,929,000 | 0.30% | Call | |
| 34 | BANK OF AMERICA CORP /DE/ | 190,500 | 3,843,000 | 0.29% | Put | |
| 35 | LASRY MARC | 189,600 | 3,824,000 | 0.29% | Put | |
| 36 | PNC FINANCIAL SERVICES GROUP, INC. | 182,138 | 3,674,000 | 0.28% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 176,640 | 3,563,000 | 0.27% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 153,886 | 3,104,000 | 0.23% | ||
| 39 | LAZARD ASSET MANAGEMENT LLC | 153,655 | 3,099,000 | 0.23% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 151,930 | 3,064,000 | 0.23% | ||
| 41 | Graham Capital Management, L.P. | 150,000 | 3,026,000 | 0.23% | Put | |
| 42 | CRITERION CAPITAL MANAGEMENT LLC | 150,000 | 3,026,000 | 0.23% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 148,079 | 2,987,000 | 0.23% | ||
| 44 | D. E. Shaw & Co., Inc. | 145,000 | 2,925,000 | 0.22% | Put | |
| 45 | NORTHERN TRUST CORP | 143,643 | 2,898,000 | 0.22% | ||
| 46 | PEAK6 Group LLC | 139,700 | 2,818,000 | 0.21% | Put | |
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 133,571 | 2,694,000 | 0.20% | ||
| 48 | GEODE CAPITAL MANAGEMENT, LLC | 132,880 | 2,680,000 | 0.20% | ||
| 49 | BARCLAYS PLC | 131,900 | 2,638,000 | 0.20% | Put | |
| 50 | Sculptor Capital LP | 126,900 | 2,560,000 | 0.19% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
