| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 8,592,106 | 41,499,000 | 15.97% | ||
| 2 | ORBIMED ADVISORS LLC | 5,546,100 | 26,788,000 | 10.31% | ||
| 3 | Capital World Investors | 4,769,000 | 23,034,000 | 8.87% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,427,642 | 21,386,000 | 8.23% | ||
| 5 | BAKER BROS. ADVISORS LP | 4,034,112 | 19,485,000 | 7.50% | ||
| 6 | FMR LLC | 2,746,953 | 13,268,000 | 5.11% | ||
| 7 | JPMORGAN CHASE & CO | 2,583,619 | 12,479,000 | 4.80% | ||
| 8 | BlackRock Fund Advisors | 2,175,394 | 10,507,000 | 4.04% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,153,207 | 10,400,000 | 4.00% | ||
| 10 | VANGUARD GROUP INC | 1,641,574 | 7,928,000 | 3.05% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 1,611,438 | 7,783,000 | 3.00% | ||
| 12 | SENZAR ASSET MANAGEMENT, LLC | 1,172,700 | 5,664,000 | 2.18% | ||
| 13 | CLINTON GROUP INC | 1,156,336 | 5,585,000 | 2.15% | ||
| 14 | WALL STREET ASSOCIATES | 1,054,300 | 5,092,000 | 1.96% | ||
| 15 | STATE STREET CORP | 957,395 | 4,624,000 | 1.78% | ||
| 16 | D. E. Shaw & Co., Inc. | 834,602 | 4,031,000 | 1.55% | ||
| 17 | NORTHERN TRUST CORP | 603,500 | 2,915,000 | 1.12% | ||
| 18 | ALTRINSIC GLOBAL ADVISORS LLC | 576,645 | 2,785,000 | 1.07% | ||
| 19 | State of New Jersey Common Pension Fund D | 559,082 | 2,700,000 | 1.04% | ||
| 20 | Allianz Asset Management GmbH | 486,720 | 2,351,000 | 0.90% | ||
| 21 | JENNISON ASSOCIATES LLC | 437,399 | 2,113,000 | 0.81% | ||
| 22 | ASCEND CAPITAL, LLC | 426,226 | 2,059,000 | 0.79% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 304,435 | 1,470,000 | 0.57% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 298,163 | 1,440,000 | 0.55% | ||
| 25 | Bank of New York Mellon Corp | 282,429 | 1,364,000 | 0.53% | ||
| 26 | DAFNA Capital Management LLC | 240,190 | 1,160,000 | 0.45% | ||
| 27 | MASON STREET ADVISORS, LLC | 226,790 | 1,095,000 | 0.42% | ||
| 28 | ROYAL BANK OF CANADA | 208,570 | 1,008,000 | 0.39% | ||
| 29 | DEUTSCHE BANK AG\ | 208,547 | 1,006,000 | 0.39% | ||
| 30 | BlackRock Investment Management, LLC | 186,039 | 899,000 | 0.35% | ||
| 31 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 178,000 | 860,000 | 0.33% | ||
| 32 | TURNER INVESTMENTS LLC | 170,520 | 824,000 | 0.32% | ||
| 33 | Catalyst Capital Advisors LLC | 160,000 | 773,000 | 0.30% | ||
| 34 | NJ State Employees Deferred Compensation Plan | 130,000 | 628,000 | 0.24% | ||
| 35 | COMMONWEALTH BANK OF AUSTRALIA | 129,670 | 626,000 | 0.24% | ||
| 36 | Nationwide Fund Advisors | 124,101 | 599,000 | 0.23% | ||
| 37 | BAILARD, INC. | 120,000 | 580,000 | 0.22% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,200 | 567,000 | 0.22% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 109,884 | 531,000 | 0.20% | ||
| 40 | GOLDMAN SACHS GROUP INC | 107,411 | 519,000 | 0.20% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105,683 | 510,000 | 0.20% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 103,900 | 502,000 | 0.19% | Call | |
| 43 | PRIMECAP MANAGEMENT CO/CA/ | 104,000 | 502,000 | 0.19% | ||
| 44 | TEACHERS ADVISORS, LLC | 90,243 | 436,000 | 0.17% | ||
| 45 | NOMURA HOLDINGS INC | 83,616 | 403,000 | 0.16% | ||
| 46 | BARCLAYS PLC | 100,300 | 401,000 | 0.15% | Put | |
| 47 | BARCLAYS PLC | 100,300 | 401,000 | 0.15% | Call | |
| 48 | Private Wealth Partners, LLC | 81,000 | 391,000 | 0.15% | ||
| 49 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 77,590 | 375,000 | 0.14% | ||
| 50 | Swiss National Bank | 73,100 | 353,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
