| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 8,574,624 | 52,562,000 | 15.72% | ||
| 2 | BAKER BROS. ADVISORS LP | 6,508,622 | 39,898,000 | 11.94% | ||
| 3 | ORBIMED ADVISORS LLC | 5,768,400 | 35,360,000 | 10.58% | ||
| 4 | Capital World Investors | 4,769,000 | 29,234,000 | 8.75% | ||
| 5 | FMR LLC | 3,045,109 | 18,667,000 | 5.58% | ||
| 6 | BlackRock Fund Advisors | 2,382,273 | 14,603,000 | 4.37% | ||
| 7 | STATE STREET CORP | 2,312,705 | 14,182,000 | 4.24% | ||
| 8 | VANGUARD GROUP INC | 2,001,385 | 12,268,000 | 3.67% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,751,070 | 10,734,000 | 3.21% | ||
| 10 | SENZAR ASSET MANAGEMENT, LLC | 1,722,100 | 10,556,000 | 3.16% | ||
| 11 | ARMISTICE CAPITAL, LLC | 1,600,000 | 9,808,000 | 2.93% | ||
| 12 | D. E. Shaw & Co., Inc. | 943,968 | 5,786,000 | 1.73% | ||
| 13 | Invesco Ltd. | 679,366 | 4,164,000 | 1.25% | ||
| 14 | NORTHERN TRUST CORP | 594,488 | 3,645,000 | 1.09% | ||
| 15 | ALTRINSIC GLOBAL ADVISORS LLC | 576,645 | 3,535,000 | 1.06% | ||
| 16 | State of New Jersey Common Pension Fund D | 559,082 | 3,427,000 | 1.03% | ||
| 17 | DAFNA Capital Management LLC | 531,032 | 3,255,000 | 0.97% | SH | |
| 18 | GREAT POINT PARTNERS LLC | 485,000 | 2,973,000 | 0.89% | ||
| 19 | AQR CAPITAL MANAGEMENT LLC | 472,187 | 2,895,000 | 0.87% | ||
| 20 | JENNISON ASSOCIATES LLC | 443,432 | 2,718,000 | 0.81% | ||
| 21 | NEXT CENTURY GROWTH INVESTORS LLC | 431,638 | 2,645,000 | 0.79% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 395,229 | 2,423,000 | 0.72% | ||
| 23 | GOLDMAN SACHS GROUP INC | 383,000 | 2,348,000 | 0.70% | Put | |
| 24 | FIRST MANHATTAN CO. LLC. | 375,881 | 2,304,000 | 0.69% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 372,833 | 2,285,000 | 0.68% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 347,847 | 2,132,000 | 0.64% | ||
| 27 | Bank of New York Mellon Corp | 329,630 | 2,020,000 | 0.60% | ||
| 28 | Rock Springs Capital Management LP | 325,000 | 1,992,000 | 0.60% | ||
| 29 | GOLDMAN SACHS GROUP INC | 304,240 | 1,865,000 | 0.56% | ||
| 30 | ALLIANCEBERNSTEIN L.P. | 286,033 | 1,753,000 | 0.52% | ||
| 31 | DEUTSCHE BANK AG\ | 255,769 | 1,567,000 | 0.47% | ||
| 32 | Numeric Investors LLC | 247,708 | 1,518,000 | 0.45% | ||
| 33 | CREDIT SUISSE AG/ | 226,138 | 1,386,000 | 0.41% | ||
| 34 | BlackRock Investment Management, LLC | 211,325 | 1,295,000 | 0.39% | ||
| 35 | PUTNAM INVESTMENTS LLC | 200,042 | 1,226,000 | 0.37% | ||
| 36 | NORGES BANK | 190,476 | 1,168,000 | 0.35% | ||
| 37 | RENAISSANCE TECHNOLOGIES LLC | 173,936 | 1,066,000 | 0.32% | ||
| 38 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 160,600 | 984,000 | 0.29% | ||
| 39 | TEACHERS ADVISORS, LLC | 149,210 | 915,000 | 0.27% | ||
| 40 | CQS Cayman LP | 137,944 | 846,000 | 0.25% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 135,300 | 830,000 | 0.25% | ||
| 42 | Opus Point Partners Management, LLC | 130,000 | 797,000 | 0.24% | ||
| 43 | NJ State Employees Deferred Compensation Plan | 130,000 | 797,000 | 0.24% | ||
| 44 | Allianz Asset Management GmbH | 129,539 | 794,000 | 0.24% | ||
| 45 | Nationwide Fund Advisors | 126,717 | 777,000 | 0.23% | ||
| 46 | ACADIAN ASSET MANAGEMENT LLC | 108,889 | 667,000 | 0.20% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107,286 | 658,000 | 0.20% | ||
| 48 | ROYAL BANK OF CANADA | 105,761 | 648,000 | 0.19% | ||
| 49 | FRED ALGER MANAGEMENT, LLC | 98,850 | 606,000 | 0.18% | ||
| 50 | Swiss National Bank | 94,600 | 580,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
