| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 8,830,836 | 30,642,000 | 15.03% | ||
| 2 | BAKER BROS. ADVISORS LP | 6,508,622 | 22,585,000 | 11.08% | ||
| 3 | ORBIMED ADVISORS LLC | 5,768,400 | 20,016,000 | 9.82% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,445,374 | 11,955,000 | 5.87% | ||
| 5 | ARMISTICE CAPITAL, LLC | 3,330,000 | 11,555,000 | 5.67% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 3,237,705 | 11,235,000 | 5.51% | ||
| 7 | FMR LLC | 2,668,709 | 9,260,000 | 4.54% | ||
| 8 | BlackRock Fund Advisors | 2,452,513 | 8,510,000 | 4.18% | ||
| 9 | SENZAR ASSET MANAGEMENT, LLC | 2,150,090 | 7,460,812 | 3.66% | ||
| 10 | VANGUARD GROUP INC | 2,107,347 | 7,312,000 | 3.59% | ||
| 11 | STATE STREET CORP | 1,943,556 | 6,741,000 | 3.31% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,653,502 | 5,738,000 | 2.82% | ||
| 13 | CITADEL ADVISORS LLC | 1,493,660 | 5,183,000 | 2.54% | ||
| 14 | ALPS ADVISORS INC | 98,730 | 3,426,000 | 1.68% | ||
| 15 | D. E. Shaw & Co., Inc. | 788,764 | 2,737,000 | 1.34% | ||
| 16 | Visium Asset Management, LP | 750,000 | 2,603,000 | 1.28% | ||
| 17 | Capital World Investors | 703,666 | 2,442,000 | 1.20% | ||
| 18 | ALTRINSIC GLOBAL ADVISORS LLC | 676,645 | 2,348,000 | 1.15% | ||
| 19 | NORTHERN TRUST CORP | 660,915 | 2,294,000 | 1.13% | ||
| 20 | State of New Jersey Common Pension Fund D | 559,082 | 1,940,000 | 0.95% | ||
| 21 | Rock Springs Capital Management LP | 555,000 | 1,926,000 | 0.94% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 537,370 | 1,865,000 | 0.92% | ||
| 23 | DAFNA Capital Management LLC | 470,612 | 1,633,000 | 0.80% | SH | |
| 24 | GOLDMAN SACHS GROUP INC | 420,253 | 1,458,000 | 0.72% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 380,096 | 1,318,000 | 0.65% | ||
| 26 | DEUTSCHE BANK AG\ | 373,055 | 1,293,000 | 0.63% | ||
| 27 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 368,395 | 1,278,000 | 0.63% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 345,438 | 1,199,000 | 0.59% | ||
| 29 | Trexquant Investment LP | 332,300 | 1,153,000 | 0.57% | ||
| 30 | Bank of New York Mellon Corp | 287,514 | 998,000 | 0.49% | ||
| 31 | BlackRock Investment Management, LLC | 209,638 | 727,000 | 0.36% | ||
| 32 | NORGES BANK | 190,476 | 661,000 | 0.32% | ||
| 33 | CITIGROUP INC | 181,951 | 632,000 | 0.31% | ||
| 34 | Spark Investment Management LLC | 167,700 | 580,000 | 0.28% | ||
| 35 | CQS Cayman LP | 157,944 | 548,000 | 0.27% | ||
| 36 | ROYAL BANK OF CANADA | 157,957 | 548,000 | 0.27% | ||
| 37 | AQR CAPITAL MANAGEMENT LLC | 151,269 | 525,000 | 0.26% | ||
| 38 | TEACHERS ADVISORS, LLC | 149,210 | 518,000 | 0.25% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 135,300 | 470,000 | 0.23% | ||
| 40 | GOLDMAN SACHS GROUP INC | 135,000 | 468,000 | 0.23% | Put | |
| 41 | NJ State Employees Deferred Compensation Plan | 130,000 | 451,000 | 0.22% | ||
| 42 | Allianz Asset Management GmbH | 129,539 | 450,000 | 0.22% | ||
| 43 | Nationwide Fund Advisors | 124,387 | 432,000 | 0.21% | ||
| 44 | TUDOR INVESTMENT CORP ET AL | 109,200 | 379,000 | 0.19% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 106,886 | 371,000 | 0.18% | ||
| 46 | Swiss National Bank | 104,300 | 362,000 | 0.18% | ||
| 47 | PRIMECAP MANAGEMENT CO/CA/ | 91,000 | 316,000 | 0.16% | ||
| 48 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 87,298 | 303,000 | 0.15% | ||
| 49 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 83,947 | 291,000 | 0.14% | ||
| 50 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 77,590 | 269,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
