| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 8,317,976 | 45,665,000 | 14.72% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 6,287,374 | 34,518,000 | 11.13% | ||
| 3 | ORBIMED ADVISORS LLC | 5,768,400 | 31,669,000 | 10.21% | ||
| 4 | BAKER BROS. ADVISORS LP | 3,475,672 | 19,081,000 | 6.15% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 3,105,914 | 17,051,000 | 5.50% | ||
| 6 | RUBRIC CAPITAL MANAGEMENT, LLC | 2,800,000 | 15,372,000 | 4.95% | ||
| 7 | FMR LLC | 2,668,709 | 14,651,000 | 4.72% | ||
| 8 | BlackRock Fund Advisors | 2,321,425 | 12,745,000 | 4.11% | ||
| 9 | VANGUARD GROUP INC | 2,192,668 | 12,038,000 | 3.88% | ||
| 10 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 2,153,696 | 11,824,000 | 3.81% | ||
| 11 | STATE STREET CORP | 1,883,455 | 10,340,000 | 3.33% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,651,847 | 9,069,000 | 2.92% | ||
| 13 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 1,295,778 | 7,114,000 | 2.29% | ||
| 14 | J. Goldman & Co LP | 1,156,888 | 6,351,000 | 2.05% | ||
| 15 | Rock Springs Capital Management LP | 1,100,000 | 6,039,000 | 1.95% | ||
| 16 | ARMISTICE CAPITAL, LLC | 1,080,000 | 5,929,000 | 1.91% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 803,627 | 4,412,000 | 1.42% | ||
| 18 | ROYCE & ASSOCIATES LP | 690,200 | 3,789,000 | 1.22% | ||
| 19 | NORTHERN TRUST CORP | 679,564 | 3,731,000 | 1.20% | ||
| 20 | ALTRINSIC GLOBAL ADVISORS LLC | 606,645 | 3,330,000 | 1.07% | ||
| 21 | NATIXIS | 495,000 | 2,718,000 | 0.88% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 383,689 | 2,106,000 | 0.68% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 337,091 | 1,851,000 | 0.60% | ||
| 24 | Bank of New York Mellon Corp | 284,708 | 1,562,000 | 0.50% | ||
| 25 | DEUTSCHE BANK AG\ | 271,153 | 1,487,000 | 0.48% | ||
| 26 | D. E. Shaw & Co., Inc. | 262,259 | 1,440,000 | 0.46% | ||
| 27 | State of New Jersey Common Pension Fund D | 249,082 | 1,367,000 | 0.44% | ||
| 28 | MORGAN STANLEY | 227,195 | 1,247,000 | 0.40% | ||
| 29 | BlackRock Investment Management, LLC | 209,495 | 1,150,000 | 0.37% | ||
| 30 | PointState Capital LP | 200,000 | 1,098,000 | 0.35% | ||
| 31 | NORGES BANK | 190,476 | 1,046,000 | 0.34% | ||
| 32 | PEAK6 Group LLC | 175,000 | 961,000 | 0.31% | Put | |
| 33 | GOLDMAN SACHS GROUP INC | 174,761 | 960,000 | 0.31% | ||
| 34 | KENNEDY CAPITAL MANAGEMENT LLC | 150,123 | 824,000 | 0.27% | ||
| 35 | TEACHERS ADVISORS, LLC | 148,960 | 818,000 | 0.26% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 135,300 | 743,000 | 0.24% | ||
| 37 | GOLDMAN SACHS GROUP INC | 135,000 | 741,000 | 0.24% | Put | |
| 38 | Allianz Asset Management GmbH | 129,539 | 722,000 | 0.23% | ||
| 39 | NJ State Employees Deferred Compensation Plan | 130,000 | 714,000 | 0.23% | ||
| 40 | Nationwide Fund Advisors | 125,057 | 687,000 | 0.22% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 108,872 | 598,000 | 0.19% | ||
| 42 | Swiss National Bank | 104,300 | 573,000 | 0.18% | ||
| 43 | ING GROEP NV | 103,000 | 564,000 | 0.18% | ||
| 44 | PRIMECAP MANAGEMENT CO/CA/ | 91,000 | 500,000 | 0.16% | ||
| 45 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 87,298 | 479,000 | 0.15% | ||
| 46 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 85,057 | 467,000 | 0.15% | ||
| 47 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 77,590 | 426,000 | 0.14% | ||
| 48 | ACADIAN ASSET MANAGEMENT LLC | 63,211 | 347,000 | 0.11% | ||
| 49 | RHUMBLINE ADVISERS | 61,138 | 336,000 | 0.11% | ||
| 50 | ProShare Advisors LLC | 59,380 | 326,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
