| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 8,587,927 | 75,316,000 | 15.88% | ||
| 2 | BAKER BROS. ADVISORS LP | 6,903,628 | 60,545,000 | 12.77% | ||
| 3 | ORBIMED ADVISORS LLC | 5,546,100 | 48,639,000 | 10.26% | ||
| 4 | Capital World Investors | 4,769,000 | 39,726,000 | 8.38% | ||
| 5 | JPMORGAN CHASE & CO | 2,397,412 | 21,025,000 | 4.43% | ||
| 6 | BlackRock Fund Advisors | 2,354,081 | 20,645,000 | 4.35% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,842,143 | 16,156,000 | 3.41% | ||
| 8 | VANGUARD GROUP INC | 1,784,820 | 15,653,000 | 3.30% | ||
| 9 | STATE STREET CORP | 1,758,994 | 15,425,000 | 3.25% | ||
| 10 | SENZAR ASSET MANAGEMENT, LLC | 1,088,700 | 9,548,000 | 2.01% | ||
| 11 | D. E. Shaw & Co., Inc. | 1,081,545 | 9,485,000 | 2.00% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 1,067,264 | 9,360,000 | 1.97% | ||
| 13 | FMR LLC | 1,066,436 | 9,353,000 | 1.97% | ||
| 14 | Allianz Asset Management GmbH | 956,430 | 8,387,000 | 1.77% | ||
| 15 | RTW INVESTMENTS, LP | 842,568 | 7,389,000 | 1.56% | ||
| 16 | OXFORD ASSET MANAGEMENT LLP | 681,449 | 5,976,000 | 1.26% | ||
| 17 | NORTHERN TRUST CORP | 587,885 | 5,156,000 | 1.09% | ||
| 18 | ALTRINSIC GLOBAL ADVISORS LLC | 576,645 | 5,057,000 | 1.07% | ||
| 19 | State of New Jersey Common Pension Fund D | 559,082 | 4,903,000 | 1.03% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 516,287 | 4,528,000 | 0.95% | ||
| 21 | EverPoint Asset Management, LLC | 490,000 | 4,297,000 | 0.91% | ||
| 22 | JENNISON ASSOCIATES LLC | 437,571 | 3,837,000 | 0.81% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 427,536 | 3,749,000 | 0.79% | ||
| 24 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 402,412 | 3,529,000 | 0.74% | ||
| 25 | TWO SIGMA INVESTMENTS, LP | 348,126 | 3,053,000 | 0.64% | ||
| 26 | Bank of New York Mellon Corp | 320,834 | 2,814,000 | 0.59% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 312,784 | 2,742,000 | 0.58% | ||
| 28 | CQS Cayman LP | 275,000 | 2,412,000 | 0.51% | ||
| 29 | SYSTEMATIC FINANCIAL MANAGEMENT LP | 255,575 | 2,241,000 | 0.47% | ||
| 30 | ROYAL BANK OF CANADA | 250,967 | 2,201,000 | 0.46% | ||
| 31 | PUTNAM INVESTMENTS LLC | 238,041 | 2,087,000 | 0.44% | ||
| 32 | Rock Springs Capital Management LP | 235,000 | 2,061,000 | 0.43% | ||
| 33 | TFS CAPITAL LLC | 229,234 | 2,010,000 | 0.42% | ||
| 34 | CITADEL ADVISORS LLC | 227,227 | 1,993,000 | 0.42% | ||
| 35 | MASON STREET ADVISORS, LLC | 226,790 | 1,989,000 | 0.42% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 222,325 | 1,950,000 | 0.41% | ||
| 37 | DEUTSCHE BANK AG\ | 213,644 | 1,873,000 | 0.40% | ||
| 38 | NORGES BANK | 190,476 | 1,670,000 | 0.35% | ||
| 39 | BlackRock Investment Management, LLC | 188,367 | 1,652,000 | 0.35% | ||
| 40 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 178,650 | 1,567,000 | 0.33% | ||
| 41 | CREDIT SUISSE AG/ | 166,867 | 1,464,000 | 0.31% | ||
| 42 | GOLDMAN SACHS GROUP INC | 163,570 | 1,435,000 | 0.30% | ||
| 43 | Opus Point Partners Management, LLC | 152,000 | 1,333,000 | 0.28% | ||
| 44 | TEACHERS ADVISORS, LLC | 142,217 | 1,247,000 | 0.26% | ||
| 45 | Invesco Ltd. | 131,599 | 1,154,000 | 0.24% | ||
| 46 | NJ State Employees Deferred Compensation Plan | 130,000 | 1,140,000 | 0.24% | ||
| 47 | Nationwide Fund Advisors | 128,340 | 1,126,000 | 0.24% | ||
| 48 | BAILARD, INC. | 120,000 | 1,052,000 | 0.22% | ||
| 49 | Spark Investment Management LLC | 118,600 | 1,040,000 | 0.22% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,200 | 1,028,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
