| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 8,465,645 | 60,275,000 | 15.31% | ||
| 2 | BAKER BROS. ADVISORS LP | 6,508,622 | 46,341,000 | 11.77% | ||
| 3 | ORBIMED ADVISORS LLC | 5,546,100 | 39,488,000 | 10.03% | ||
| 4 | Capital World Investors | 4,769,000 | 33,955,000 | 8.62% | ||
| 5 | STATE STREET CORP | 3,187,163 | 22,695,000 | 5.76% | ||
| 6 | FMR LLC | 3,141,917 | 22,371,000 | 5.68% | ||
| 7 | BlackRock Fund Advisors | 2,389,071 | 17,010,000 | 4.32% | ||
| 8 | VANGUARD GROUP INC | 1,943,488 | 13,838,000 | 3.51% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,838,038 | 13,087,000 | 3.32% | ||
| 10 | SENZAR ASSET MANAGEMENT, LLC | 1,456,900 | 10,373,000 | 2.63% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 1,146,133 | 8,160,000 | 2.07% | ||
| 12 | Allianz Asset Management GmbH | 950,105 | 6,765,000 | 1.72% | ||
| 13 | D. E. Shaw & Co., Inc. | 894,807 | 6,371,000 | 1.62% | ||
| 14 | Invesco Ltd. | 649,434 | 4,624,000 | 1.17% | ||
| 15 | NORTHERN TRUST CORP | 586,206 | 4,173,000 | 1.06% | ||
| 16 | ALTRINSIC GLOBAL ADVISORS LLC | 576,645 | 4,106,000 | 1.04% | ||
| 17 | State of New Jersey Common Pension Fund D | 559,082 | 3,981,000 | 1.01% | ||
| 18 | JENNISON ASSOCIATES LLC | 438,974 | 3,125,000 | 0.79% | ||
| 19 | NEXT CENTURY GROWTH INVESTORS LLC | 429,729 | 3,059,000 | 0.78% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 422,439 | 3,008,000 | 0.76% | ||
| 21 | ASCEND CAPITAL, LLC | 400,000 | 2,849,000 | 0.72% | ||
| 22 | EverPoint Asset Management, LLC | 400,000 | 2,848,000 | 0.72% | ||
| 23 | AQR CAPITAL MANAGEMENT LLC | 386,477 | 2,752,000 | 0.70% | ||
| 24 | GOLDMAN SACHS GROUP INC | 383,000 | 2,727,000 | 0.69% | Put | |
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 371,476 | 2,644,000 | 0.67% | ||
| 26 | CQS Cayman LP | 350,092 | 2,493,000 | 0.63% | ||
| 27 | ACADIAN ASSET MANAGEMENT LLC | 331,367 | 2,360,000 | 0.60% | ||
| 28 | Bank of New York Mellon Corp | 321,121 | 2,286,000 | 0.58% | ||
| 29 | DRIEHAUS CAPITAL MANAGEMENT LLC | 313,325 | 2,231,000 | 0.57% | ||
| 30 | Rock Springs Capital Management LP | 310,000 | 2,207,000 | 0.56% | ||
| 31 | GOLDMAN SACHS GROUP INC | 244,190 | 1,739,000 | 0.44% | ||
| 32 | PUTNAM INVESTMENTS LLC | 230,383 | 1,641,000 | 0.42% | ||
| 33 | DEUTSCHE BANK AG\ | 208,572 | 1,484,000 | 0.38% | ||
| 34 | OXFORD ASSET MANAGEMENT LLP | 206,187 | 1,468,000 | 0.37% | ||
| 35 | Spark Investment Management LLC | 191,000 | 1,359,000 | 0.35% | ||
| 36 | NORGES BANK | 190,476 | 1,356,000 | 0.34% | ||
| 37 | BlackRock Investment Management, LLC | 188,309 | 1,341,000 | 0.34% | ||
| 38 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 175,650 | 1,251,000 | 0.32% | ||
| 39 | TEACHERS ADVISORS, LLC | 174,280 | 1,241,000 | 0.32% | ||
| 40 | FIRST MANHATTAN CO. LLC. | 151,900 | 1,081,000 | 0.27% | ||
| 41 | JACOBS LEVY EQUITY MANAGEMENT, INC | 146,800 | 1,045,000 | 0.27% | ||
| 42 | A.R.T. Advisors, LLC | 142,598 | 1,015,000 | 0.26% | ||
| 43 | NJ State Employees Deferred Compensation Plan | 130,000 | 926,000 | 0.24% | ||
| 44 | Opus Point Partners Management, LLC | 130,000 | 926,000 | 0.24% | ||
| 45 | Numeric Investors LLC | 129,708 | 924,000 | 0.23% | ||
| 46 | Nationwide Fund Advisors | 127,209 | 906,000 | 0.23% | ||
| 47 | TWO SIGMA INVESTMENTS, LP | 124,850 | 889,000 | 0.23% | ||
| 48 | BAILARD, INC. | 120,000 | 854,000 | 0.22% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,200 | 835,000 | 0.21% | ||
| 50 | DAFNA Capital Management LLC | 116,259 | 828,000 | 0.21% | SH |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
